Patents by Inventor Rohan T. Baker

Rohan T. Baker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of protein degradation in living cells with dipeptides
    Patent number: 5766927
    Abstract: The half-life of a Type I, II and III non-compartmentalized intracellular proteins is increased in living eukaryotic cells by contacting the cells with a regulator having an amino-terminal amino acid residue which is the same or similar to the amino-terminal residue of the intracellular protein. The regulator is a dipeptide, a small polypeptide or a carboxyl-terminal derivative of an amino acid. The dipeptide or small polypeptide has an N-terminal amino acid residue which is Arg, Lys or His for the Type I protein, Phe, Leu, Trp, Tyr or Ile for the Type II protein and Ala, Ser or Thr for the Type III protein. The carboxyl-terminal derivative of an amino acid may be an amino acid modified at its C-terminus by the addition of a group selected from methyl, ethyl, propyl, butyl and isobutyl. The amino acid modified is the N-terminal amino acid residue of the dipeptide or small polypeptide for the respective Type I, II and III proteins.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: June 16, 1998
    Assignee: Massachusetts Institute of Technology
    Inventors: Rohan T. Baker, David K. Gonda, Alexander Varshavsky
  • Ubiquitin-specific proteases
    Patent number: 5683904
    Abstract: The disclosure relates to a generic class of ubiquitin-specific proteases which specifically cleave at the C-terminus of the ubiquitin moiety in a ubiquitin fusion protein irrespective of the size of the ubiquitin fusion protein. More specifically, the disclosure relates to ubiquitin-specific proteases of this class which have been isolated from a cell. The disclosure also relates to isolated DNA sequences encoding the proteases of this class.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 4, 1997
    Assignee: Massachusetts Institute of Technology
    Inventors: Rohan T. Baker, John W. Tobias, Alexander Varshavsky
  • Ubiquitin-specific proteases
    Patent number: 5494818
    Abstract: The disclosure relates to a generic class of ubiquitin-specific proteases which specifically cleave at the C-terminus of the ubiquitin moiety in a ubiquitin fusion protein irrespective of the size of the ubiquitin fusion protein. More specifically, the disclosure relates to ubiquitin-specific proteases of this class which have been isolated from a cell. The disclosure also relates to isolated DNA sequences encoding the proteases of this class.
    Type: Grant
    Filed: January 15, 1993
    Date of Patent: February 27, 1996
    Assignee: Massachusetts Institute of Technology
    Inventors: Rohan T. Baker, John W. Tobias, Alexander Varshavsky
  • Nucleic acid encoding ubiquitin-specific proteases
    Patent number: 5212058
    Abstract: The disclosure relates to a generic class of ubiquitin-specific proteases which specifically cleave at the C-terminus of the ubiquitin moiety in a ubiquitin fusion protein irrespective of the size of the ubiquitin fusion protein. More specifically, the disclosure relates to ubiquitin-specific proteases of this class which have been isolated from a cell. The disclosure also relates to isolated DNA sequences encoding the proteases of this class.
    Type: Grant
    Filed: November 8, 1991
    Date of Patent: May 18, 1993
    Assignee: Massachusetts Institute of Technology
    Inventors: Rohan T. Baker, John W. Tobias, Alexander Varshavsky