Abstract: The invention concerns a novel method for synthesis of 1,4-morpholine-2,5-diones of formula (I), wherein: R, R1, R2, R3 and R4 independently represent various radicals, by oxidizing the ketone function of a cyclic compound of formula (II).

Abstract: The invention concerns a device for injecting a solid medicine (10) comprising a body (2) inside which moves along a general forward moving axis (X-X) a bevelled (34) needle (4) wherein is introduced the medicine (10), said injection device (1) further comprising retaining means for preventing the medicine from falling (10) prior to being injected. The invention is characterized in that the medicine (10) is retained through an elastic deformation imparted to the needle (4) by the retaining means or by an elastic deformation of the retaining means themselves, or still by the combined flexibility of those two means.

Abstract: The invention relates to a device which is used to inject an implant (6) into tissues (50). The inventive device is characterized in that it comprises : a main hollow body (2; 2?) having a hollow needle (4; 4?) fixed thereto, into which the implant (6) is introduced; a secondary body (26; 26?) which is disposed coaxially inside the main body (2; 2?) and which surrounds the needle (4; 4?); and a plunger rod (36; 36?) which can slide coaxially inside the hollow needle (4; 4?).

Abstract: The invention concerns the use or a fragment of botulinum toxin having said toxin activity for preparing a medicine for reversibly desensitizing an area of the skin, said skin area being designed to receive injections. Said injections can be related, for example, to repeated delivery of insulin, growth hormones or other medicines in injectable form.

Abstract: A catalytic lactide and glycolide copolymerization system comprising a trifluoromethane sulfonate as a catalyst and copolymerization additive and a copolymerization process.

Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.

Abstract: The invention relates to a novel method for the synthesis of 2,5-dioxane-1,4-diones having formula (I), comprising the oxidation of the ketone function of a cyclic compound having formula (II), wherein R1, R2, R3 and R4 independently represent the hydrogen atom, halo, (C2-C6) alkenyl, (C3-C7)cycloalkyl, cyclohexenyl and a radical having formula —(CH2)m—V—W.

Abstract: The invention relates to the use of a liquid or semi-solid formulation of botulinum toxin for the preparation of a medicament intended to treat a disorder characterised by bladder spasms (e.g. urinary incontinence due to unstable bladder or unstable detrusor sphincter, voiding complications due to detrusor overactivity or unstable detrusor sphincter, urinary retention secondary to spastic sphincter or hypertrophied bladder neck and neurogenic bladder dysfunction secondary to Parkinson's disease, spinal cord injury, stroke or multiple sclerosis or characterised by a spasm reflex), wherein said medicament is for administration by infusion into the bladder or by other methods that do not involve injection into the bladder wall.

Abstract: The invention features a safety injection device for injecting a liquid or semi-solid composition into a subject.

Abstract: The invention concerns a device for back injecting an implant (30) into the skin (22) of a subject, said device (1) include a hollow main body (10), to which a hollow needle (28) is fixed into which the implant (30) is introduced, a secondary body (12; 114) coaxially arranged inside the main body (10) and surrounding the needle (28) and a piston rod (88) able to slide coaxially inside said hollow needle (28) and whose position relative to said needle (28) remains unchanged when the back injection device (1) is pressed against the subject's skin (22) to allow the needle (28) to penetrate said subject's skin and when the secondary body (12) retracts inside the main body (10), the piston rod (88) penetrating the interior of the hollow needle (28) to hold the implant (30) at the required depth in the subject's skin (22) during withdrawal of the hollow needle (28) from the subject's skin (22), during which the secondary body (12; 114) exits the main body (10), characterized in that it includes means for the elasti

Abstract: The invention relates to a novel method for the synthesis of 2,5-dioxane-1,4-diones having formula (I), comprising the oxidation of the ketone function of a cyclic compound having formula (II), wherein R1, R2, R3 and R4 independently represent the hydrogen atom, halo, (C2-C6) alkenyl, (C3-C7)cycloalkyl, cyclohexenyl and a radical having formula —(CH2)m—V—W.

Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.

Abstract: The use of a catalytic ring-opening lactide and glycolide (co)oligomerization system consisting of a strongly acidic ion-exchange resin-type polymeric catalyst and a (co)oligomerization additive, and a lactide and glycolide (co)oligomerization method using said catalytic system, are disclosed.

Abstract: The invention relates to a long-acting solid formulation for parenteral administration, comprising a) triptorelin acetate and b) one or more excipients comprising a polymer or copolymer of lactic and/or glycolic acid or a mixture of polymers and/or copolymers of lactic acid and/or glycolic acid, said formulation containing 10 to 99% of triptorelin acetate by weight with relation to the total weight of the formulation. Said formulation is obtained by means of a method comprising the fusion of a mixture of triptorelin acetate and the excipient(s) on the fusion/extrusion of the triptorelin acetate with the excipient(s), said formulation being embodied such as to release the triptorelin acetate over a duration of at least one week, once administered parenterally to a patient.

Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues.

Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.

Abstract: A catalytic lactide and glycolide copolymerization system comprising a trifluoromethane sulfonate as a catalyst and copolymerization additive and a copolymerization process.

Abstract: The invention relates to a pre-filled injection device for injecting a liquid or semisolid composition into a subject, said injection device comprising: a housing (1) containing at its distal end the liquid or semisolid composition (2), a plunger (3) arranged to slide within the housing (1) to which is affixed a plunger stick (7) extending longitudinally from the plunger to the outside of the housing (1), a hollow needle (4) affixed to the distal end of the housing (1), said needle (4) connecting the interior part of the housing (1) with the outside where it extends longitudinally, and an airtight needle shield (5) which protects said needle (4), characterized in that said device further comprises a cap (6) designed to fit around the housing's proximal end and to fully cover said plunger stick (7), said cap (6) both preventing its accidental pushing or breakage before use and being adapted to receive the injection device once the injection into the subject has been carried out.

Abstract: The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues.

Abstract: The invention features a method of administering one or more therapeutic agents to a patient and delivering said agent or agents continuously over an extended period of time, said method comprising: obtaining a pharmaceutical composition including a peptide carrier, one or more therapeutic agents, and up to 30 percent, by weight, of a pharmaceutically acceptable, soluble, monomeric carrier; and parenterally administering said pharmaceutical composition to a subject by injection, wherein said composition automatically forms a gel after interaction with the patient's bodily fluids and releases said peptide carrier and said agent or agents continuously within the patient over an extended period.