Abstract: An information processing system having neuron-like signal processors that are interconnected by synapse-like processing junctions that simulates and extends capabilities of biological neural networks. The information processing systems uses integrate-and-fire neurons and Temporally Asymmetric Hebbian learning (spike timing-dependent learning) to adapt the synaptic strengths. The synaptic strengths of each neuron are guaranteed to become optimal during the course of learning either for estimating the parameters of a dynamic system (system identification) or for computing the first principal component. This neural network is well-suited for hardware implementations, since the learning rule for the synaptic strengths only requires computing either spike-time differences or correlations. Such hardware implementation may be used for predicting and recognizing audiovisual information or for improving cortical processing by a prosthetic device.