Patents by Inventor Roland H. Stauber

Roland H. Stauber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence
    Patent number: 6265548
    Abstract: The present invention is directed to mutants of the jellyfish Aequorea victoria green fluorescent protein (GFP) having at least 5 and preferably greater than 20 times the specific green fluorescence of the wild type protein. In other embodiments, the invention comprises mutant blue fluorescent proteins (BFPs) that emit an enhanced blue fluorescence. The invention also encompasses the expression of nucleic acids that encode a mutant GFP or BFP in a wide variety of engineered host cells, and the isolation of engineered proteins having increased fluorescent activity. The novel mutants of the present invention allow for a significantly more sensitive detection of fluorescence in engineered host cells than is possible with GFP or with its known mutants.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: July 24, 2001
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: George N. Pavlakis, George A. Gaitanaris, Roland H. Stauber, John N. Vournakis
  • Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence
    Patent number: 6027881
    Abstract: The present invention is directed to mutants of the jellyfish Aequorea victoria green fluorescent protein (GFP) having at least 5 and preferably greater than 20 times the specific green fluorescence of the wild type protein. In other embodiments, the invention comprises mutant blue fluorescent proteins (BFPs) that emit an enhanced blue fluorescence. The invention also encompasses the expression of nucleic acids that encode a mutant GFP or BFP in a wide variety of engineered host cells, and the isolation of engineered proteins having increased fluorescent activity. The novel mutants of the present invention allow for a significantly more sensitive detection of fluorescence in engineered host cells than is possible with GFP or with its known mutants.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: February 22, 2000
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: George N. Pavlakis, George A. Gaitanaris, Roland H. Stauber, John N. Vournakis