Patents by Inventor Rolf Berge

Rolf Berge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120276212
    Abstract: The present invention concerns a composition prepared from a combination of plant oil and/or fish oil and a compound comprising non. ?-oxidizable fatty acid analogues, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. The present invention also concerns an animal feed prepared from a combination of plant oil and/or fish oil and a compound comprising non ?-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.
    Type: Application
    Filed: March 19, 2012
    Publication date: November 1, 2012
    Applicant: LIFE SCIENCE NUTRITION AS
    Inventor: Rolf Berge
  • Patent number: 8206739
    Abstract: The present invention relates to the use of a enzyme treated fish protein hydrolyzate (FPH). The FPH material lowers the concentration of cholesterol in plasma, and triglycerides in the liver. FPH also induces a favorable change in the fatty acid pattern, and lowers the concentration of homocysteine in plasma. A preferable embodiment of the invention relates to the use of FPH as an anti-atherogenic and cardio protective agent, either given as a pharmaceutical or as a functional food.
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: June 26, 2012
    Assignee: Atlantic Garden AS
    Inventor: Rolf Berge
  • Publication number: 20120101161
    Abstract: The present invention relates to fatty acid analogues of the general formula R1-[xi-CH2]n—COOR2 and in particular to a method of treating inflammatory disorder selected from the group consisting of rheumatoid arthritis, systemic vasculitis, systemic lupus erythematosus, systemic sclerosis, dermatomyositis, and polymyositis; comprising administering to a mammal in need thereof, an effective amount of tetradecylthioaceticacid or tetradecylselenoacetic acid; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: December 29, 2011
    Publication date: April 26, 2012
    Applicant: LIFE SCIENCE NUTRITION AS
    Inventors: Rolf Berge, Pal Aukrust
  • Patent number: 8088825
    Abstract: The present invention relates to fatty acid analogues of the general formula R1-[xi-CH2]n—COOR2 and in particular to a method of treating inflammatory disorder selected from the group consisting of rheumatoid arthritis, systemic vasculitis, systemic lupus erythematosus, systemic sclerosis, dermatomyositis, and polymyositis; comprising administering to a mammal in need thereof, an effective amount of tetradecylthioaceticacid or tetradecylselenoacetic acid; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 27, 2001
    Date of Patent: January 3, 2012
    Assignee: Life Science Nutrition AS
    Inventors: Rolf Berge, Pal Aukrust
  • Patent number: 7902399
    Abstract: The present invention relates to novel fatty acid analogous of the general formula (I): R1—[xi—CH2]n—COOR2 wherein R1 is: a C6-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C6-C24 alkyne, and/or a C6-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C2-C5 acyloxy or C1-C4 alkyl, and wherein R2 represents hydrogen or C1-C4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, and with the proviso that if R1 is an alkye, then the carbon-carbon triple bond is positioned between the (?-1) carbon and the (?-2) carbon, or between the (?-2) carbon and the (?-3) carbon, or between the (?-3) carbon and the (?-4) carbon, a
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: March 8, 2011
    Assignee: Thia Medica AS
    Inventors: Rolf Berge, Leiv K. Sydnes, Jon Songstad
  • Patent number: 7659242
    Abstract: The present invention concerns a composition prepared from a combination of non ?-oxidizable fatty acid entities and a protein material, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. An alternative embodiment of the invention includes oil in the composition The present invention also concerns an animal feed prepared from a combination of a protein material and a compound comprising non ?-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: February 9, 2010
    Assignee: Thia Medica AS
    Inventor: Rolf Berge
  • Publication number: 20100029973
    Abstract: The invention comprises the use of compounds comprising non ?-oxidizable fatty acid entities according to formula (I) or (II) for the preparation of a pharmaceutical composition for the prevention and/or treatment of conditions associated with low/decreased bone mineral density (BMD), and/or for increasing the BMD by decreasing the bone resorption.
    Type: Application
    Filed: July 10, 2006
    Publication date: February 4, 2010
    Inventor: Rolf Berge
  • Patent number: 7378443
    Abstract: A fatty acid analogue of the general formula: R1-[xi-CH2]n—COOR2, wherein R1 is: a C2-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C2-C24 alkyne, and/or a C1-C24 alkyl, or a C1-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C2-C5 acyloxy or C1-C4 alkyl, and wherein R2 represents hydrogen or C1-C4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, and or a salt, prodrug or complex thereof is used in the treatment and/or prevention of primary and secondary metastatic neoplasms.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: May 27, 2008
    Assignee: Thia Medica, AS
    Inventor: Rolf Berge
  • Publication number: 20070141083
    Abstract: The present invention relates to the use of a single-cell protein material (SCP). The SCP material lowers the concentration of cholesterol in plasma, and triglycerides in the liver. SCP also induces a favourable change in the fatty acid pattern, and lowers the concentration of homocysteine in plasma. A preferable embodiment of the invention relates to the use of SCP as an anti-atherogenic and cardio protective agent, either given as a pharmaceutical or as nutritional composition, e.g. as a functional food.
    Type: Application
    Filed: July 2, 2004
    Publication date: June 21, 2007
    Inventors: Rolf Berge, Gunnar Kleppe
  • Publication number: 20070142274
    Abstract: The present invention relates to the use of a enzyme treated fish protein hydrolyzate (FPH). The FPH material lowers the concentration of cholesterol in plasma, and triglycerides in the liver. FPH also induces a favourable change in the fatty acid pattern, and lowers the concentration of homocysteine in plasma. A preferable embodiment of the invention relates to the use of FPH as an anti-atherogenic and cardio protective agent, either given as a pharmaceutical or as a functional food.
    Type: Application
    Filed: July 2, 2004
    Publication date: June 21, 2007
    Inventor: Rolf Berge
  • Patent number: 7230029
    Abstract: The present invention relates to fatty acid analogues of the general formula (I): R1-[xi-CH2]n—COOR2 wherein R1 is; a C1–C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C1–C24 alkyne, and/or a C1–C24 alkyl, or a C1–C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1–C4 alkoxy, C2–C4 alkylthio, C1–C5 acyloxy or C1–C4 alkyl, and wherein R2 represents hydrogen or C1–C4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the (?-1) carbon and the (?-2) carbon, or between the (?-2) carbon and the (?-3) carbon, or between t
    Type: Grant
    Filed: September 27, 2001
    Date of Patent: June 12, 2007
    Assignee: Thia Medica AS
    Inventors: Rolf Berge, Karsten Kristiansen
  • Publication number: 20070015795
    Abstract: The present invention concerns a composition prepared from a combination of non ?-oxidizable fatty acid entities and a protein material, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. An alternative embodiment of the invention includes oil in the composition The present invention also concerns an animal feed prepared from a combination of a protein material and a compound comprising non ?-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.
    Type: Application
    Filed: July 19, 2005
    Publication date: January 18, 2007
    Inventor: Rolf Berge
  • Publication number: 20070009608
    Abstract: The present invention concerns a composition prepared from a combination of plant oil and/or fish oil and a compound comprising non ?-oxidizable fatty acid analogues, and the use of said composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of insulin resistance, obesity, diabetes, fatty liver, hypercholesterolemia, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders. The present invention also concerns an animal feed prepared from a combination of plant oil and/or fish oil and a compound comprising non ?-oxidizable fatty acid analogues, the use of said feed for improving the body composition of an animal, and a product produced from said animal.
    Type: Application
    Filed: July 19, 2005
    Publication date: January 11, 2007
    Inventor: Rolf Berge
  • Publication number: 20060105987
    Abstract: The present invention provides a lipid compound comprising at least one non-polar moiety and a polar moiety, wherein each or at least one non-polar moiety is of the formula X—Y-Z-, wherein X is a hydrocarbyl chain, Y is selected from at least one of S, Se, SO2, SO, and O, and Z is an optional hydrocarbyl group, wherein the polar moiety is of the formula —[C(O)]mPHG, wherein PHG is a polar head group, and wherein m is the number of non-polar moieties.
    Type: Application
    Filed: June 16, 2003
    Publication date: May 18, 2006
    Inventors: Andrew Miller, Michael Jorgensen, Rolf Berge, Jon Skorve
  • Patent number: 7026356
    Abstract: The present invention relates to novel fatty acid analogues of the general formula (I): CH3—[CH2]m—[xi—CH2]n—COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and wherein R represents hydrogen or C1–C4 alkyl, with the proviso that at least one of the Xi is not CH2, or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: April 11, 2006
    Inventor: Rolf Berge
  • Publication number: 20050165103
    Abstract: The present invention relates to fatty acid analogues of the general formula I: R1-[xi-CH2]n—COOR2; wherein R1 is; a C1-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or, a C1-C24 alkyne, and/or, a C1-C424 alkyl, or a C1-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C2-C5 acyloxy or C1-C4 alkyl, and; wherein R2 represents hydrogen or C1-C4 alkyl, and; wherein n is an integer from 1 to 12, and; wherein i is an old number and indicates the position relative to COOR2, and; wherein Xi independent of each other are selected from the group comprising, O, S, SO, SO2, Se and CH2, and; with the proviso that at least one of the Xi is not CH2; which can be used for the treatment and/or prevention of inflammatory disorders.
    Type: Application
    Filed: November 27, 2001
    Publication date: July 28, 2005
    Inventors: Rolf Berge, Pal Aukrust
  • Publication number: 20040213442
    Abstract: The present invention relates to novel fatty acid analogous of the general formula (I): R1—[xi—CH2]n—COOR2 wherein R1 is: a C6-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C6-C24 alkyne, and/or a C6-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy.
    Type: Application
    Filed: November 12, 2002
    Publication date: October 28, 2004
    Inventors: Rolf Berge, Leiv K Sydnes, Jon Songstad
  • Publication number: 20040024063
    Abstract: The present invention relates to fatty acid analogues of general formula (I): R1-[xi-CH2]n—COOR2, wherein is: a C1-C24 alkene with one or more double bonds and/or with one or more triple bonds; and/or a C1-C24 alkyne, and/or a C1-C24 alkyl, or an alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C2-C5 acyloxy or C1-C4 alkyl, and wherein R2 represents hydrogen or C1-C4 alkyl, and wherein is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, which can be used for the treatment and/or prevention of primary and secondary metastatic neoplasms.
    Type: Application
    Filed: January 2, 2003
    Publication date: February 5, 2004
    Inventor: Rolf Berge
  • Publication number: 20040019108
    Abstract: The present invention relates to fatty acid analogues of the general formula (I): R1-[xi-CH2]n—COOR2 wherein R1 is; a C1-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C1-C24 alkyne, and/or a C1-C24 alkyl, or a C1-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C2-C4 alkylthio, C1-C5 acyloxy or C1-C4 alkyl, and wherein R2 represents hydrogen or C1-C4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the (&ohgr;-1) carbon and the (&ohgr;-2) carbon, or between the (&ohgr;-2) carbon and
    Type: Application
    Filed: May 8, 2003
    Publication date: January 29, 2004
    Inventors: Rolf Berge, Karsten Kristiansen
  • Publication number: 20020198259
    Abstract: The present invention relates to novel fatty acid analogues of the general formula (I): CH3—[CH2]m—[xi—CH2]n—COOR, wherein n is an integer from 1 to 12, and wherein m is an integer from 0 to 23, and wherein i is an odd number which indicates the position relative to COOR, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and wherein R represents hydrogen or C1-C4 alkl, with the proviso that at least one of the Xi is not CH2, or a salt, prodrug or complex thereof, for the preparation of a pharmaceutical composition for the treatment and/or prevention of primary and/or secondary stenosis. Further the present invention relates to the use of said compounds for the prevention and/or treatment of a disease caused by procedural vascular trauma and/or pathological proliferation of smooth muscle cells, and/or an increased level of plasma homocysteine.
    Type: Application
    Filed: May 17, 2002
    Publication date: December 26, 2002
    Inventor: Rolf Berge