Patents by Inventor Rolf Brickl
Rolf Brickl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4873080Abstract: Galenic compositions containing an oral antidiabetic agent and having an improved release of active substance as well as processes for producing these compositions are provided. The pharmaceutical compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the anti-diabetically active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. The solution is applied to a water-insoluble carrier, the solvent is evaporated, and the residue is further processed to yield the various compositions.Type: GrantFiled: September 30, 1987Date of Patent: October 10, 1989Assignee: Dr. Karl Thomae GmbHInventors: Rolf Brickl, Gottfried Schepky, Eckhard Rupprecht, Andreas Greischel
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Patent number: 4863724Abstract: Galenic compositions containing an oral antidiabetic agent and having an improved release of active substance are provided, as well as processes for producing these compositions. The compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of the metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the antidiabetic active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. Polyvinylpyrrolidone is dissolved as carrier in this solution, but the carrier may simultaneously serve as the solubilizing adjuvant. This solution is further processed with other excipients to form pharmaceutical compositions.Type: GrantFiled: July 23, 1987Date of Patent: September 5, 1989Assignee: Dr. Karl Thomae GmbHInventors: Gottfried Schepky, Rolf Brickl, Eckhard Rupprecht, Andreas Greischel
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Patent number: 4708868Abstract: This invention is directed to novel galenic preparation forms for providing an oral anti-diabetic agent having an improved release of active substance and to processes for producing these preparation forms. The pharmaceutical compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the anti-diabetically active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. The solution is applied to a water-insoluble carrier, the solvent is evaporated, and the residue is further processed to yield the various preparation forms.Type: GrantFiled: May 31, 1984Date of Patent: November 24, 1987Assignee: Dr. Karl Thomae GmbHInventors: Rolf Brickl, Gottfried Schepky, Eckhard Rupprecht, Andreas Greischel
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Patent number: 4696815Abstract: The invention is directed to novel galenic preparation forms for providing an oral anti-diabetic agent having an improved release of active substance and processes for producing these preparation forms. The novel pharmaceutical compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of the metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the anti-diabetic active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. Polyvinyl pyrrolidone is dissolved as carrier in this solution, but the carrier may simultaneously serve as the solubilizing adjuvant. This solution is further processed with other excipients to form corresponding preparation forms.Type: GrantFiled: May 31, 1984Date of Patent: September 29, 1987Inventors: Gottfried Schepky, Rolf Brickl, Eckhard Rupprecht, Andreas Greischel
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Patent number: 4650664Abstract: This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol or its acid addition salt.Type: GrantFiled: September 3, 1985Date of Patent: March 17, 1987Assignee: Dr. Karl Thomae GmbHInventors: Gottfried Schepky, Rolf Brickl, Peter Gruber, Jochen Schmid, Ursula Springmeier
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Patent number: 4596705Abstract: This invention relates to vehicles for the administration of mopidamol. More specifically, this invention relates to a method of treating cardiovascular disorders, malignancy, or thrombosis in a host in need of such treatment which comprises administering to said host a cardiovascularly, antimetastic, or antithrombotic effective amount of a composition comprised of (i) mopidamol or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 1 acid equivalent to 1 mol of mopidamol.Type: GrantFiled: October 7, 1983Date of Patent: June 24, 1986Assignee: Dr. Karl Thomae GmbHInventors: Gottfried Schepky, Rolf Brickl, Peter Gruber, Jochen Schmid, Ursula Springmeier
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Patent number: 4578264Abstract: This invention relates to a pharmaceutical dosage unit composition consisting essentially of a gelatin capsule containing (1) a disintegrating core comprising clonidine, said disintegrating core having a readily water-soluble coating, and (2) a plurality of non-disintegrating cores comprising clonidine, said non-disintegrating cores having a coating consisting of from 20 to 90 percent by weight of a water-insoluble film former and from 10 to 80 percent by weight of a water-soluble polymer, the diameter of each of the disintegrating and non-disintegrating cores being at least about 5 mm.Type: GrantFiled: April 27, 1984Date of Patent: March 25, 1986Assignee: Boehringer Ingelheim GmbHInventors: Herbert Stricker, Bernhard Freund, Heribert Harwalik, Karl L. Rominger, Siegfried Darda, Volkmar Haselbarth, Dietrich Arndts, Wolf D. Bechtel, Gerhard Bozler, Rolf Brickl, Peter Gruber
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Patent number: 4459279Abstract: A pharmaceutical dosage unit retard form having a constant, pH-independent release rate of active ingredient, consisting of a core comprising an active ingredient, and a semi-permeable diffusion coating over the core, where the coating consists of a water-insoluble film-former, a water-soluble polymer and eventually an acid-insoluble polymer incorporated therein.Type: GrantFiled: August 18, 1982Date of Patent: July 10, 1984Assignee: Boehringer Ingelheim GmbHInventors: Herbert Stricker, Bernhard Freund, Heribert Harwalik, Karl L. Rominger, Siegfried Darda, Volkmar Haselbarth, Dietrich Arndts, Wolf D. Bechtel, Gerhard Bozler, Rolf Brickl, Peter Gruber
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Patent number: 4427648Abstract: This invention relates to vehicles for the administration of dipyridamole. More specifically, this invention relates to a method of treating cardiovascular disorders in a host in need of such treatment which comprises administering to said host a cardiovascularly effective amount of a composition comprised of (i) dipyridamole or an acid addition salt thereof and (ii) at least one pharmacologically acceptable acid or acid substance, the total amount of acid from acid addition salt present and acid or acid substance being in a ratio of at least about 5 acid equivalents to 1 mol of dipyridamole, preferably in the form of particles having particle sizes of from about 0.1 to 2.0 mm.Type: GrantFiled: June 17, 1982Date of Patent: January 24, 1984Assignee: Dr. Karl Thomae GmbHInventors: Rolf Brickl, Peter Gruber, Gottfried Schepky, Gerhard Bozler
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Dipyricamole sustained release forms comprising lacquer-coated particles and the preparation thereof
Patent number: 4367217Abstract: This invention relates to a composition for the sustained release of dipyridamole which comprises (i) spheroid particles comprised of dipyridamole or crystallized salts thereof and pharmacologically acceptable acid or acid substance, and (ii) a coating surrounding said spheroid particles, said coating being comprised of from about 50 to 100 percent by weight of acid-insoluble lacquers soluble in intestinal juices and from about 0 to 50 percent by weight of lacquers insoluble in gastric and intestinal juices and said coating being present in an amount of from about 3 to 30 percent by weight, based on the weight of the spheroid particles, and to the preparation of such a composition.Type: GrantFiled: December 31, 1980Date of Patent: January 4, 1983Assignee: Boehringer Ingelheim GmbHInventors: Peter Gruber, Rolf Brickl, Gerhard Bozler, Herbert Stricker -
Patent number: 4361546Abstract: A pharmaceutical dosage unit retard form having a constant, pH-independent release rate of active ingredient, consisting of a core comprising an active ingredient, and a semi-permeable diffusion coating over the core, were the coating consists of a water-insoluble film-former, a water-soluble polymer and eventually an acid-insoluble polymer incorporated therein.Type: GrantFiled: June 15, 1981Date of Patent: November 30, 1982Assignee: Boehringer Ingelheim GmbHInventors: Herbert Stricker, Bernhard Freund, Heribert Harwalik, Karl L. Rominger, Siegfried Darda, Volkmar Haselbarth, Dietrich Arndts, Wolf D. Bechtel, Gerhard Bozler, Rolf Brickl, Peter Gruber
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Patent number: 4327114Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical to or different from each other, are each hydrogen, halogen, branched alkyl of 3 to 12 carbon atoms or cycloalkyl of 3 to 12 carbon atoms, provided, however, that at least one of R.sub.1 to R.sub.4 is other than hydrogen; the compounds are useful as dermatologics for the treatment of psoriasis, dandruff, ichthyosis and hyperkeratotic skin conditions.Type: GrantFiled: January 8, 1981Date of Patent: April 27, 1982Assignee: Boehringer Ingelheim GmbHInventors: Rolf Brickl, Hans Eberhardt
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Patent number: 4229479Abstract: Pharmaceutical, cosmetic and pesticidal compositions containing a trifluoroacetyl-resorcinol of the formula ##STR1## wherein R.sub.2 and R.sub.4, which may be identical to or different from each other, are each hydrogen or methyl, andR.sub.3 and R.sub.5, which may be identical to or different from each other, are each hydrogen or ethyl.Type: GrantFiled: August 30, 1978Date of Patent: October 21, 1980Assignee: Boehringer Ingelheim GmbHInventors: Rolf Brickl, Hans Eberhardt, Karl-Richard Appel, Uwe Lechner, Walter Merk
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Patent number: 4225619Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is perfluoroalkyl of 1 to 8 carbon atoms or 2,2,3,3-tetrafluoro-cyclobutyl,R.sub.2 and R.sub.4, which may be identical to or different from each other, are each hydrogen, alkyl of 1 to 10 carbon atoms, aliphatic acyl of 2 to 18 carbon atoms, benzoyl, salicyloyl or phenylacetyl, andR.sub.3 and R.sub.5, which may be identical to or different from each other, are each alkyl of 3 to 18 carbon atoms, halogen, nitro, p-toluenesulfonyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclododecyl, methylcyclohexyl, dimethylcyclohexyl, benzyl, methylthio or ##STR2## where R.sub.1, R.sub.2 and R.sub.4 have the meanings previously defined,Q is --CH.sub.2 -- or --S--, andG is R.sub.5, as above defined, orQ is R.sub.3, as above defined, andG is --CH.sub.2 -- or --S--,R.sub.3 may, in addition, also be hydroxyl, methoxy, methyl or cyano, andR.sub.5 may also be methyl, orone of substituents R.sub.3 and R.sub.Type: GrantFiled: March 19, 1979Date of Patent: September 30, 1980Assignee: Boehringer Ingelheim GmBHInventors: Rolf Brickl, Hans Eberhardt, Karl-Richard Appel, Uwe Lechner, Walter Merk