Patents by Inventor Rolf Hagedorn
Rolf Hagedorn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9149813Abstract: Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.Type: GrantFiled: August 16, 2012Date of Patent: October 6, 2015Assignee: PERKINELMER CELLULAR TECHNOLOGIES GERMANY GMBHInventors: Torsten Müller, Thomas Schnelle, Rolf Hagedorn
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Patent number: 8451138Abstract: A method for operating a cryostorage device (100), especially for biological samples, is described which comprises a sample carrier (10) to receive at least one sample (11) and a data storage (20), wherein data are inductively transmitted from the data storage device (20) into a wireless transmission channel (40) and/or conversely using a resonant circuit (30) connected to the data storage device (20).Type: GrantFiled: June 10, 2011Date of Patent: May 28, 2013Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.Inventors: Heiko Zimmermann, Guenter R. Fuhr, Rolf Hagedorn
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Publication number: 20120305398Abstract: Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.Type: ApplicationFiled: August 16, 2012Publication date: December 6, 2012Applicant: PerkinElmer Cellular Technologies Germany GmbHInventors: Torsten Müller, Thomas Schnelle, Rolf Hagedorn
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Patent number: 8262883Abstract: Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.Type: GrantFiled: March 17, 2004Date of Patent: September 11, 2012Assignee: PerkinElmer Cellular Technologies Germany, GmbHInventors: Torsten Müller, Thomas Schnelle, Rolf Hagedorn
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Publication number: 20110277486Abstract: A method for operating a cryostorage device (100), especially for biological samples, is described which comprises a sample carrier (10) to receive at least one sample (11) and a data storage (20), wherein data are inductively transmitted from the data storage device (20) into a wireless transmission channel (40) and/or conversely using a resonant circuit (30) connected to the data storage device (20).Type: ApplicationFiled: June 10, 2011Publication date: November 17, 2011Applicant: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.Inventors: Heiko ZIMMERMANN, Guenter R. FUHR, Rolf HAGEDORN
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Patent number: 7958791Abstract: A method for operating a cryostorage device (100), especially for biological samples, is described which comprises a sample carrier (10) to receive at least one sample (11) and a data storage (20), wherein data are inductively transmitted from the data storage device (20) into a wireless transmission channel (40) and/or conversely using a resonant circuit (30) connected to the data storage device (20).Type: GrantFiled: January 22, 2003Date of Patent: June 14, 2011Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forshung e.V.Inventors: Heiko Zimmermann, Günter R. Fuhr, Rolf Hagedorn
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Patent number: 7439075Abstract: A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem (10) is described, whereby the fluid flow converges with at least one output flow to form a discharge flow at the end of a discharge channel (14) of the microsystem, and the discharge flow is delivered through a conduction element (19). A microsystem with a flow output device for implementation of this method is also described.Type: GrantFiled: February 8, 2001Date of Patent: October 21, 2008Assignee: Perkinelmer Cellular Technologies Germany GmbHInventors: Gunter Fuhr, Stephen Graham Shirley, Torsten Muller, Thomas Schnelle, Rolf Hagedorn
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Publication number: 20060289341Abstract: Methods and devices for the separation of particles (20, 21, 22) in a compartment (30) of a fluidic microsystem (100) are described, in which the movement of a liquid (10) in which particles (20, 21, 22) are suspended with a predetermined direction of flow through the compartment (30), and the generation of a deflecting potential in which at least a part of the particles (20, 21, 22) is moved relative to the liquid in a direction of deflection are envisaged, whereby further at least one focusing potential is generated, so that at least a part of the particles is moved opposite to the direction of deflection relative to the liquid by dielectrophoresis under the effect of high-frequency electrical fields, and guiding of particles with different electrical, magnetic or geometric properties into different flow areas (11, 12) in the liquid takes place.Type: ApplicationFiled: March 17, 2004Publication date: December 28, 2006Applicant: EVOTEC AGInventors: Torsten Muller, Thomas Schnelle, Rolf Hagedorn
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Patent number: 7070684Abstract: A microsystem adapted for dielectrophoretic manipulation of particles in a suspension liquid wherein the microsystem has a channel with channel walls and a longitudinal extension. An electrode arrangement is present which has at least one microelectrode on at least one of the channel walls. This acts to generate a field barrier which crosses the channel at least partly. The microelectrode has a band-shape or has a multitude of straight electrode sections connected to each other. The band-shape has a predetermined curvature or the straight electrode sections are arranged with predetermined different angles so that the field barrier has a predetermined curvature relative to the longitudinal extension of the channel.Type: GrantFiled: June 28, 1999Date of Patent: July 4, 2006Assignee: Evotec Technologies GmbHInventors: Günter Fuhr, Thomas Schnelle, Rolf Hagedorn, Torsten Müller
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Patent number: 6931864Abstract: With a method for cryo-preservation, at least one specimen is arranged on a storage substrate and specimen data, which are characteristic for features of the specimen, are stored at specific positions. Also, a storage substrate for cryo-preservation with such a method is described.Type: GrantFiled: December 7, 2001Date of Patent: August 23, 2005Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Günter Fuhr, Rolf Hagedorn, Heiko Zimmermann
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Publication number: 20050120235Abstract: A method and devices for controlling access to a data processing device, in particular a data memory, having an access filter circuit (10) are described, whereby the access filter circuit (10) is operated with enabled access in a read-write mode at a normal operating temperature and with limited access at an access protection temperature which is lower than the normal operating temperature.Type: ApplicationFiled: January 22, 2003Publication date: June 2, 2005Inventors: Heiko Zimmermann, Guenter Fuhr, Rolf Hagedorn
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Publication number: 20050069861Abstract: A method for operating a cryostorage device (100), especially for biological samples, is described which comprises a sample carrier (10) to receive at least one sample (11) and a data storage (20), wherein data are inductively transmitted from the data storage device (20) into a wireless transmission channel (40) and/or conversely using a resonant circuit (30) connected to the data storage device (20).Type: ApplicationFiled: January 22, 2003Publication date: March 31, 2005Inventors: Heiko Zimmermann, Gunter Fuhr, Rolf Hagedorn
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Patent number: 6841356Abstract: For the cell trace based testing of biological cells, wherein the cells (16) are applied to an at least partially structured and/or surface modified substrate (11) and move adhesively over surface track regions (13, 15) of the substrate while producing cell traces (14a, 14b) consisting of material residues separated from the cells, cell tests are performed on the cell traces. A process for cell cultivation on biocompatible modified substrates whose surfaces are covered by cell traces is also described.Type: GrantFiled: December 10, 1999Date of Patent: January 11, 2005Assignee: Evotec Technologies GmbHInventors: Gunter Fuhr, Rolf Hagedorn, Stephen Graham Shirley, Ekkehard Richter
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Patent number: 6749736Abstract: Electrode arrangement (10) in a microsystem adapted for dielectrophoretic manipulation of particles (30) in a suspension fluid in a channel (21), wherein at least one electrode (11, 11a, 11b, 12) is arranged on a lateral wall of the channel (21), the electrode (11, 11a, 11b, 12) consisting of a plurality of electrode segments adapted to generate at least one field gradient for influencing the movement paths of the particles (30) in the channel (21). In one embodiment of the invention, the particles are moved in the microsystem by exposure to centrifugal and/or gravitational forces.Type: GrantFiled: February 22, 2001Date of Patent: June 15, 2004Assignee: Evotec Technologies GmbHInventors: Günter Fuhr, Thomas Schnelle, Rolf Hagedorn, Torsten Müller
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Patent number: 6727451Abstract: To manipulate microparticles in a fluid that intersects a first channel or several first channels as a stream, one or more microparticles (14) are exposed to electrical field barriers that change their direction from the direction of flow toward the edge of the flow to a lateral hole (17) of the respective first channel. As a result, microparticles can be moved back and forth between streaming fluids. Preferred applications include treatment, separating, sorting or confinement procedures.Type: GrantFiled: November 30, 2000Date of Patent: April 27, 2004Assignee: Evotec Technologies GmbHInventors: Günter Fuhr, Rolf Hagedorn, Torsten Müller, Thomas Schnelle, Gabriele Gradl
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Publication number: 20040065093Abstract: With a method for cryo-preservation, at least one specimen is arranged on a storage substrate and specimen data, which are characteristic for features of the specimen, are stored at specific positions. Also, a storage substrate for cryo-preservation with such a method is described.Type: ApplicationFiled: September 8, 2003Publication date: April 8, 2004Inventors: Gunter Fuhr, Rolf Hagedorn, Heiko Zimmermann
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Patent number: 6663757Abstract: The aim of the invention is to convectively move at least one liquid in a channel of a microsystem which comprises a predetermined channel direction. To this end, the liquid is, in a partial section of the channel, subjected to an electric field gradient and optionally to a thermal gradient. The gradients are generated in the partial section corresponding to a predetermined field direction, whereby the field direction differs from the channel direction.Type: GrantFiled: August 6, 2001Date of Patent: December 16, 2003Assignee: Evotec Technologies GmbHInventors: Günter Führ, Torsten Müller, Thomas Schnelle, Rolf Hagedorn
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Patent number: 6646238Abstract: For sample picking on a cryosubstrate, on which multiple cryopreserved samples are each positioned at preselected sample positions, individual samples are selectively separated mechanically or thermally from the cryosubstrate and transferred to a target substrate.Type: GrantFiled: March 19, 2002Date of Patent: November 11, 2003Assignee: Evotec Oai AGInventors: Günter Fuhr, Rolf Hagedorn
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Publication number: 20030108452Abstract: A method of discharging a fluid flow with suspended microparticles from a fluidic microsystem (10) is described, whereby the fluid flow converges with at least one output flow to form a discharge flow at the end of a discharge channel (14) of the microsystem, and the discharge flow is delivered through a conduction element (19). A microsystem with a flow output device for implementation of this method is also described.Type: ApplicationFiled: October 21, 2002Publication date: June 12, 2003Inventors: Gunter Fuhr, Stephen Graham, Torsten Muller, German Schnelle, Rolf Hagedorn
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Patent number: 6542778Abstract: A process for treating a biological or synthetic object subjected to an electrical field in a surrounding liquid medium for a predetermined pulse time (t1), the electrical field being formed by at least two electrodes including actuating at least once during the pulse time (t1) each of the electrodes as an anode and as a cathode, to cause at each electrode a polarity reversal and alternating electrolytic increases and reductions in pH of at least a portion of the liquid medium, subjecting the object during the pulse time (t1) to a number of electrical partial pulses which have a frequency in the range of 1 kHz to 1 MHz and which possess partial pulse durations, with sequentially reversing polarity or field direction such that the partial pulses possess sequentially varying partial pulse durations (t11, t12), pulse forms, and/or pulse amplitudes, and selecting the partial pulse durations (t11, t12), pulse forms, and/or pulse amplitudes such that, due to the electrolytic increases and reductions in pH value, suType: GrantFiled: November 22, 2000Date of Patent: April 1, 2003Assignee: Evotec OAI AG.Inventors: Günter Fuhr, Ulrich Zimmermann, Rolf Hagedorn