Patents by Inventor Rolf Keltjens

Rolf Keltjens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR MAKING SIPONIMOD AND INTERMEDIATE THEREOF
    Publication number: 20220204446
    Abstract: The presented invention relates to a process for preparation of compound of formula (I) or a salt or a solvate thereof (i.e.) siponimod. The invention also relates to intermediates used in the process and solid forms of these intermediates.
    Type: Application
    Filed: March 29, 2020
    Publication date: June 30, 2022
    Inventors: Rolf KELTJENS, Ondrej HYLSE, Jiri PARTL
  • Pharmaceutical composition comprising amorphous lenalidomide
    Patent number: 10471156
    Abstract: The present invention relates to a pharmaceutical composition comprising an inclusion complex of amorphous lenalidomide, or a pharmaceutically acceptable salt thereof, in non-substituted ?-cyclodextrin and one or more pharmaceutically acceptable excipients. The invention further relates to the use of said composition as a medicament, particularly in the treatment of in the treatment of multiple myeloma and myelodysplastic syndromes.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: November 12, 2019
    Assignee: Synthon B.V.
    Inventors: Rolf Keltjens, Jacobus Theodorus Henricus Van Eupen, Deepak Murpani, Marta Vivancos Martinez, Lisardo Alvarez Fernandez, Luis Nogueiras Nieto
  • PREPARATION OF HALIDE PRODUCTS
    Publication number: 20190127309
    Abstract: A method for the preparation of an acyl or alkyl halide is described. In particular, the method contains, respectively, reacting a carboxylic acid or an alcohol with a halogenation agent in the presence of a base, wherein the reaction is at least partially carried out in a continuous-flow reactor.
    Type: Application
    Filed: March 29, 2017
    Publication date: May 2, 2019
    Inventors: Marc CROCKATT, Leonard Ferdinand Gerard GEERS, Rudolf Gijsbertus VAN SOMEREN, Charlotte WILES, Rolf KELTJENS, Reinerus Gerardus GIELING
  • Pharmaceutical Composition Comprising Amorphous Lenalidomide
    Publication number: 20170368197
    Abstract: The present invention relates to a pharmaceutical composition comprising an inclusion complex of amorphous lenalidomide, or a pharmaceutically acceptable salt thereof, in non-substituted ?-cyclodextrin and one or more pharmaceutically acceptable excipients. The invention further relates to the use of said composition as a medicament, particularly in the treatment of in the treatment of multiple myeloma and myelodyplastic syndromes.
    Type: Application
    Filed: December 16, 2015
    Publication date: December 28, 2017
    Inventors: Rolf KELTJENS, Jacobus Theodorus Henricus VAN EUPEN, Deepak MURPANI, Marta VIVANCOS MARTINEZ, Lisardo ALVAREZ FERNANDEZ, Luis NOGUEIRAS NIETO
  • Process for making asenapine
    Patent number: 7875729
    Abstract: Asenapine and related trans-isomer bicyclic compounds can be obtained by reducing a compound of formula (C) to preferentially form a trans-isomer compound of formula (D), followed by subsequent ring closure to form a compound of formula (B) such as asenapine.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: January 25, 2011
    Assignee: Synthon BV
    Inventors: Jie Zhu, Rolf Keltjens, Judith Firet
  • Stable salts of olanzapine
    Patent number: 7459449
    Abstract: Several salts of olanzapine, including olanzapine malonate, olanzapine glycolate, olanzapine maleate, and olanzapine benzoate, have been found to have favorable solid state characteristics.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: December 2, 2008
    Inventor: Rolf Keltjens
  • Process for making asenapine
    Publication number: 20080214832
    Abstract: Asenapine and related trans-isomer bicyclic compounds can be obtained by reducing a compound of formula (C) to preferentially form a trans-isomer compound of formula (D), followed by subsequent ring closure to form a compound of formula (B) such as asenapine.
    Type: Application
    Filed: December 21, 2007
    Publication date: September 4, 2008
    Inventors: Jie Zhu, Rolf Keltjens, Judith Firet
  • Amlodipine free base
    Patent number: 7335380
    Abstract: Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine free base are set forth.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: February 26, 2008
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker, Rolf Keltjens
  • Synthesis of olanzapine and intermediates thereof
    Patent number: 7329747
    Abstract: Olanzapine and salts thereof are made by a process that utilizes an N-formyl olanzapine intermediate of formula (4) or a salt thereof
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: February 12, 2008
    Assignee: Synthon IP Inc.
    Inventors: Rolf Keltjens, Theodorus H. A. Peters
  • Process for Making Olanzapine Form I
    Publication number: 20070066602
    Abstract: Olanzapine Form I can be made by converting olanzapine benzoate to olanzapine base in an aqueous environment and isolating and drying the resulting solid olanzapine.
    Type: Application
    Filed: August 17, 2006
    Publication date: March 22, 2007
    Inventor: Rolf Keltjens
  • Process for making bicalutamide and intermediates thereof
    Patent number: 7186854
    Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: March 6, 2007
    Assignee: Synthon IP Inc.
    Inventors: Lambertus Thijs, Rolf Keltjens, Gerrit J. B. Ettema
  • PROCESS AND COMPOSITION FOR MAKING OLANZAPINE FORM I
    Publication number: 20070021605
    Abstract: Olanzapine Form I crystals can be made by precipitation from a gas/supercritical fluid composition containing carbon dioxide.
    Type: Application
    Filed: July 19, 2006
    Publication date: January 25, 2007
    Inventors: Rolf Keltjens, Lambertus Thijs
  • Stable salts of olanzapine
    Publication number: 20050272721
    Abstract: Several salts of olanzapine, including olanzapine malonate, olanzapine glycolate, olanzapine maleate, and olanzapine benzoate, have been found to have favorable solid state characteristics.
    Type: Application
    Filed: January 27, 2005
    Publication date: December 8, 2005
    Inventor: Rolf Keltjens
  • Process for making olanzapine Form I
    Publication number: 20050272720
    Abstract: Heating a solid, preferably crystalline, olanzapine acetate can produce olanzapine Form I in high purity, free of other olanzapine forms and in good yields. The olanzapine acetate can also be used to purify raw or technical grade olanzapine and to serve as an intermediary to other forms of olanzapine base.
    Type: Application
    Filed: January 27, 2005
    Publication date: December 8, 2005
    Inventor: Rolf Keltjens
  • Synthesis of olanzapine and intermediates thereof
    Publication number: 20050267099
    Abstract: Olanzapine and salts thereof are made by a process that utilizes an N-formyl olanzapine intermediate of formula (4) or a salt thereof.
    Type: Application
    Filed: January 27, 2005
    Publication date: December 1, 2005
    Inventors: Rolf Keltjens, Theodorus Peters
  • Process for making bicalutamide and intermediates thereof
    Patent number: 6818766
    Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.
    Type: Grant
    Filed: October 2, 2002
    Date of Patent: November 16, 2004
    Assignee: Synthon BV
    Inventors: Lambertus Thijs, Rolf Keltjens, Gerrit Jan Bouke Ettema
  • Process for making bicalutamide and intermediates thereof
    Publication number: 20040068135
    Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.
    Type: Application
    Filed: October 10, 2003
    Publication date: April 8, 2004
    Inventors: Lambertus Thijs, Rolf Keltjens, Gerrit J. B. Ettema
  • Venlafaxine besylate
    Patent number: 6717015
    Abstract: Venlafaxine besylate compounds provide certain advantages over venlafaxine hydrochloride and are useful in forming pharmaceutical compositions and n treating venlafaxine-treatable diseases and conditions. Venlafaxine besylate can be easily formulated into an extended release dosage form including a hydrogel tablet as well as other matrix-based tablet compositions. A preferred tablet making process involves hot melt granulation.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: April 6, 2004
    Assignee: Synthon BV
    Inventors: Rolf Keltjens, Johannes Jan Platteeuw, Juan Cucala Escoi, Inocencia Margallo Lana, Frantisek Picha, Montserrat Gallego Luengo
  • Low water-soluble venlafaxine salts
    Patent number: 6696496
    Abstract: Low water soluble salts of venlafaxine, especially venlafaxine maleate, are provided. Such salts can provide a variety of dosage forms including hydrogel-based extended release dosage forms.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: February 24, 2004
    Assignee: Synthon BV
    Inventors: Marinus J. M. Oosterbaan, Rolf Keltjens
  • Venlafaxine besylate
    Publication number: 20030195249
    Abstract: Venlafaxine besylate compounds provide certain advantages over venlafaxine hydrochloride and are useful in forming pharmaceutical compositions and n treating venlafaxine-treatable diseases and conditions. Venlafaxine besylate can be easily formulated into an extended release dosage form including a hydrogel tablet as well as other matrix-based tablet compositions. A preferred tablet making process involves hot melt granulation.
    Type: Application
    Filed: March 27, 2003
    Publication date: October 16, 2003
    Applicant: SYNTHON BV
    Inventors: Rolf Keltjens, Johannes Jan Platteeuw, Juan Cucala Escoi, Inocencia Margallo Lana, Frantisek Picha, Montserrat Gallego Luengo