Patents by Inventor Rolf Knobel
Rolf Knobel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11630116Abstract: An automated method for determining a coagulation result of a biological sample is presented. The method includes obtaining a time series representing measurement data of a sample. The time series spans a period in which a clotting reaction is supposed to take place. The method includes obtaining a global model function configured to model measurement data of a sample in which a clotting reaction takes place. The global model function is configured to model the measurement data as a sigmoidal shape with at least one inflection point. The absolute value of the maximum curvature of the sigmoidal shape is larger on one side of the at least one inflection point than on the other side. The method includes fitting the model function to the time series representing measurement data to obtain a fitted model function and determining a coagulation result of the sample based on the fitted model function.Type: GrantFiled: June 29, 2018Date of Patent: April 18, 2023Assignee: Roche Diagnostics Operations, Inc.Inventor: Rolf Knobel
-
Publication number: 20220003788Abstract: A method of determining a level of interference with a photometric in-vitro diagnostic assay and an in-vitro diagnostic analyzer for carrying out the method are described. The method comprises treating an aliquot of a sample with at least one reagent to obtain a sample/reagent mixture and subjecting the sample/reagent mixture to a photometric measurement in order to obtain a result of the in-vitro diagnostic assay, and during the same photometric measurement determining a preliminary level of interference by semi-quantitatively determining one or more interfering substances in the same sample/reaction mixture. The method further comprises triggering a separate photometric measurement of another aliquot of the same sample either undiluted or diluted with a liquid other than a reagent in order to determine an effective level of interference by quantitatively determining the one or more interfering substances, only upon determining a preliminary level of interference above a predetermined threshold.Type: ApplicationFiled: June 22, 2021Publication date: January 6, 2022Applicant: Roche Diagnostics Operations, Inc.Inventors: Jean-Pierre Bolliger, Rik Harbers, Rolf Knobel
-
Patent number: 10458997Abstract: A method for determining a background shift is presented. The method includes obtaining a plurality of optical measurement sets of a sample taken by a sample analyzer at different points in time. Each set includes one measurement taken in a first channel and another measurement taken in a second channel different from the first channel. The plurality of optical measurement sets includes one set group and another set group. The measurements in the one set group show a higher signal change than the measurements in the other group. A first background signal is determined based on a relation of measurements in the first and second channels in the one group. A second background signal is determined based on a relation of measurements in the first and second channels in the one group and the other group. A background shift is determined based on the first and second background signals.Type: GrantFiled: August 30, 2017Date of Patent: October 29, 2019Assignee: Roche Diagnostics Operations, Inc.Inventor: Rolf Knobel
-
Patent number: 10351843Abstract: The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.Type: GrantFiled: December 22, 2015Date of Patent: July 16, 2019Assignee: Roche Molecular Systems, Inc.Inventors: Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann
-
Publication number: 20190162665Abstract: An analysis method is provided aimed at improving the linearity (precision and/or accuracy) of a quantification by a real-time nucleic acid amplification reaction RNR such as a polymerase chain reaction PCR over a wide range of analyte concentrations and/or limiting the effects of the presence of interfering substances by way of determining a quantification cycle number (Cq) of the RNR as the cycle number corresponding to an intersection of the growth curve with a combined threshold function (CTF) over the RNR cycle range comprising at least two different threshold levels, the quantification cycle number (Cq) being indicative of a quantitative and/or qualitative analysis result of a growth curve, the growth curve being indicative of the intensity of the fluorescence emission of an analyte for each amplification reaction cycle of the RNR over a RNR cycle range.Type: ApplicationFiled: February 1, 2019Publication date: May 30, 2019Applicant: Roche Molecular Systems, Inc.Inventor: Rolf Knobel
-
Publication number: 20190154716Abstract: An analytical apparatus and a method for isolating and analyzing at least one analyte are described, comprising at least one module for receiving and dispensing a sample to be analyzed, at least one module for isolating said analyte to be analyzed, at least one module for analyzing said analyte, wherein said modules (i) to (iii) are arranged along an axis.Type: ApplicationFiled: January 23, 2019Publication date: May 23, 2019Applicant: Roche Molecular Systems, Inc.Inventors: Andreas Gisler, Robert Huesler, Urs Knecht, Rolf Knobel, Heinz Trueeb
-
Publication number: 20190018927Abstract: The present disclosure is concerned with data evaluation tools, methods for analyzing a dataset, and a computer readable medium comprising a computer program code that when run on a data processing device carries out the method of the disclosure as well as a device for carrying out the method of the disclosure. The methods and devices disclosed herein are used in analytical systems that analyze biological samples.Type: ApplicationFiled: July 16, 2018Publication date: January 17, 2019Applicant: Roche Molecular System, Inc.Inventor: Rolf Knobel
-
Publication number: 20190018030Abstract: An automated method for determining a coagulation result of a biological sample is presented. The method includes obtaining a time series representing measurement data of a sample. The time series spans a period in which a clotting reaction is supposed to take place. The method includes obtaining a global model function configured to model measurement data of a sample in which a clotting reaction takes place. The global model function is configured to model the measurement data as a sigmoidal shape with at least one inflection point. The absolute value of the maximum curvature of the sigmoidal shape is larger on one side of the at least one inflection point than on the other side. The method includes fitting the model function to the time series representing measurement data to obtain a fitted model function and determining a coagulation result of the sample based on the fitted model function.Type: ApplicationFiled: June 29, 2018Publication date: January 17, 2019Applicant: Roche Diagnostics Operations, Inc.Inventor: Rolf Knobel
-
Patent number: 10081502Abstract: An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.Type: GrantFiled: June 8, 2015Date of Patent: September 25, 2018Assignee: Roche Molecular Systems, Inc.Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Markus Rinderknecht
-
Patent number: 10081503Abstract: An automated analyzer with an on-board fridge for long-term cooling of reagents, and a method for isolating and analyzing an analyte comprising long-term cooling of reagents.Type: GrantFiled: June 8, 2015Date of Patent: September 25, 2018Assignee: Roche Molecular Systems, Inc.Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Markus Rinderknecht
-
Publication number: 20180067140Abstract: A method for determining a background shift is presented. The method includes obtaining a plurality of optical measurement sets of a sample taken by a sample analyzer at different points in time. Each set includes one measurement taken in a first channel and another measurement taken in a second channel different from the first channel. The plurality of optical measurement sets includes one set group and another set group. The measurements in the one set group show a higher signal change than the measurements in the other group. A first background signal is determined based on a relation of measurements in the first and second channels in the one group. A second background signal is determined based on a relation of measurements in the first and second channels in the one group and the other group. A background shift is determined based on the first and second background signals.Type: ApplicationFiled: August 30, 2017Publication date: March 8, 2018Applicant: Roche Diagnostics Operations, Inc.Inventor: Rolf Knobel
-
Publication number: 20180000023Abstract: The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.Type: ApplicationFiled: December 22, 2015Publication date: January 4, 2018Inventors: Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann
-
Patent number: 9678092Abstract: The invention relates to a method of isolating and analyzing an analyte using an analytical apparatus which comprises modules of different types, wherein any one module of one type has a specific, pre-defined timing for carrying out its workflow.Type: GrantFiled: September 16, 2015Date of Patent: June 13, 2017Assignee: Roche Molecular Systems, Inc.Inventors: Andreas Gisler, Robert Huesler, Rolf Knobel
-
Publication number: 20160282379Abstract: An analytical apparatus and a method for isolating and analyzing at least one analyte are described, comprising at least one module for receiving and dispensing a sample to be analyzed, at least one module for isolating said analyte to be analyzed, at least one module for analyzing said analyte, wherein said modules (i) to (iii) are arranged along an axis.Type: ApplicationFiled: February 4, 2015Publication date: September 29, 2016Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Andreas Gisler, Robert Huesler, Urs Knecht, Rolf Knobel, Heinz Trueeb
-
Patent number: 9383379Abstract: A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.Type: GrantFiled: May 23, 2014Date of Patent: July 5, 2016Assignee: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Siegfried Mueller, Urs Schnieper, Heinz Trueeb
-
Patent number: 9383378Abstract: A method is described for distributing samples within an automated analyzer from a linear arrangement of sample vessels to a processing plate in a two-dimensional n×m arrangement wherein samples are sorted, followed by transfer with a pipetting device with a linear arrangement to a processing vessel in a two-dimensional n×m arrangement and subsequent processing of samples using a second pipetting device which has a two-dimensional n×m arrangement.Type: GrantFiled: May 23, 2014Date of Patent: July 5, 2016Assignee: Roche Molecular Systems, Inc.Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Siegfried Mueller, Urs Schnieper, Heinz Trueeb
-
Publication number: 20160161517Abstract: The invention relates to a method of isolating and analyzing an analyte using an analytical apparatus which comprises modules of different types, wherein any one module of one type has a specific, pre-defined timing for carrying out its workflow.Type: ApplicationFiled: February 4, 2015Publication date: June 9, 2016Applicant: Roche Molecular Systems, Inc.Inventors: Andreas Gisler, Robert Huesler, Rolf Knobel
-
Publication number: 20160161518Abstract: An analyzer for detecting or quantitating an analyte comprising a temporary storage unit for storing a reagent cassette and a method for presenting a reagent cassette present in a temporary storage unit to a pipetting device are described.Type: ApplicationFiled: December 22, 2015Publication date: June 9, 2016Inventors: Paul Frank, Andreas Gisler, Robert Huesler, Rolf Knobel, Markus Rinderknecht, Urs Schnieper
-
Patent number: 9315801Abstract: A method for separating and analyzing an analyte is provided which comprises, in a first position, transferring a liquid sample to a multiwell plate with a pipette tip, replacing the tips in the tip rack in the same position, and re-using the pipette tips for aspirating and dispensing liquid.Type: GrantFiled: May 30, 2013Date of Patent: April 19, 2016Assignee: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Renato Belz, Andreas Gisler, Robert Huesler, Rolf Knobel, Christian Thalmann
-
Publication number: 20160061731Abstract: An analysis method is provided aimed at improving the linearity (precision and/or accuracy) of a quantification by a real-time nucleic acid amplification reaction RNR such as a polymerase chain reaction PCR over a wide range of analyte concentrations and/or limiting the effects of the presence of interfering substances by way of determining a quantification cycle number (Cq) of the RNR as the cycle number corresponding to an intersection of the growth curve with a combined threshold function (CTF) over the RNR cycle range comprising at least two different threshold levels, the quantification cycle number (Cq) being indicative of a quantitative and/or qualitative analysis result of a growth curve, the growth curve being indicative of the intensity of the fluorescence emission of an analyte for each amplification reaction cycle of the RNR over a RNR cycle range.Type: ApplicationFiled: August 24, 2015Publication date: March 3, 2016Inventor: Rolf Knobel