Patents by Inventor Rolf Wolters

Rolf Wolters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11905509
    Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: February 20, 2024
    Assignee: Tissue Genesis International LLC
    Inventors: Rolf Wolters, Jules Valenti, Tom Gurski
  • Patent number: 11821824
    Abstract: Systems and methods herein are directed towards the separation of biologic material to obtain a target cell volume and/or cell concentration for harvesting. The target volume and/or concentration of cells may be obtained through a single cycle via three chambers, or by repeated cycles through one or more chambers to dilute the digestive enzymes used in the process and concentrate the harvestable cell volume to a predetermined target.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: November 21, 2023
    Assignee: TISSUE GENESIS INTERNATIONAL LLC
    Inventors: Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
  • Publication number: 20220049209
    Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.
    Type: Application
    Filed: October 27, 2021
    Publication date: February 17, 2022
    Applicant: Koligo Therapeutics, Inc.
    Inventors: Rolf WOLTERS, Jules VALENTI, Tom GURSKI
  • Patent number: 11174458
    Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: November 16, 2021
    Assignee: KOLIGO THERAPEUTICS, INC.
    Inventors: Rolf Wolters, Jules Valenti, Tom Gurski
  • Publication number: 20190112570
    Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.
    Type: Application
    Filed: December 13, 2018
    Publication date: April 18, 2019
    Applicant: TISSUE GENESIS, LLC
    Inventors: Rolf WOLTERS, Jules VALENTI, Tom GURSKI
  • Publication number: 20180002666
    Abstract: Systems and methods herein are directed towards the separation of biologic material to obtain a target cell volume and/or cell concentration for harvesting. The target volume and/or concentration of cells may be obtained through a single cycle via three chambers, or by repeated cycles through one or more chambers to dilute the digestive enzymes used in the process and concentrate the harvestable cell volume to a predetermined target.
    Type: Application
    Filed: September 18, 2017
    Publication date: January 4, 2018
    Applicant: Tissue Genesis, LLC
    Inventors: Rolf WOLTERS, Anthony YANG, Josh NELSON, Stuart K. WILLIAMS
  • Publication number: 20140207103
    Abstract: Devices and methods are provided for processing adipose tissue with a hand-held device. This device may include a processing chamber, a cannula, a vacuum source, a digestion area, and a product cell concentration chamber.
    Type: Application
    Filed: March 20, 2014
    Publication date: July 24, 2014
    Applicant: Tissue Genesis, Inc.
    Inventors: Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
  • Publication number: 20140081237
    Abstract: Devices and methods are provided for aspirating adipose tissue with a portable device. This device may include a processing chamber, a cannula, a vacuum source, a filter or screen for separating connective tissue strands from adipose tissue, a digestion area, and a product cell concentration chamber.
    Type: Application
    Filed: March 15, 2013
    Publication date: March 20, 2014
    Applicant: TISSUE GENESIS, INC.
    Inventors: Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
  • Publication number: 20110301447
    Abstract: A process and device for detecting colon cancer by classifying and annotating clinical features in video data containing colonoscopic features by applying a probabilistic analysis to intra-frame and inter-frame relationships between colonoscopic features in spatially and temporally neighboring portions of video frames, and classifying and annotating as clinical features any of the colonoscopic features that satisfy the probabilistic analysis as clinical features. Preferably the probabilistic analysis is Hidden Markove Model analysis, and the process is carried out by a computer trained using semi supervised learning from labeled and unlabeled examples of clinical features in video containing colonoscopic features.
    Type: Application
    Filed: June 7, 2011
    Publication date: December 8, 2011
    Inventors: Sun Young Park, Dustin Sargent, Ulf Peter Gustafsson, Wenjing Li, Rolf Wolters, Stephen D. Fleischer
  • Publication number: 20080058593
    Abstract: A process for providing computer aided diagnosis from video data of an organ during an examination with an endoscope, comprising analyzing and enhancing image frames from the video and detecting and diagnosing any lesions in the image frames in real time during the examination. Optionally, the image data can be used to create a 3 dimensional reconstruction of the organ.
    Type: Application
    Filed: August 21, 2007
    Publication date: March 6, 2008
    Inventors: Jia Gu, Rolf Wolters