Patents by Inventor Rolf Wolters
Rolf Wolters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11905509Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.Type: GrantFiled: October 27, 2021Date of Patent: February 20, 2024Assignee: Tissue Genesis International LLCInventors: Rolf Wolters, Jules Valenti, Tom Gurski
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Patent number: 11821824Abstract: Systems and methods herein are directed towards the separation of biologic material to obtain a target cell volume and/or cell concentration for harvesting. The target volume and/or concentration of cells may be obtained through a single cycle via three chambers, or by repeated cycles through one or more chambers to dilute the digestive enzymes used in the process and concentrate the harvestable cell volume to a predetermined target.Type: GrantFiled: September 18, 2017Date of Patent: November 21, 2023Assignee: TISSUE GENESIS INTERNATIONAL LLCInventors: Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
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Publication number: 20220049209Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.Type: ApplicationFiled: October 27, 2021Publication date: February 17, 2022Applicant: Koligo Therapeutics, Inc.Inventors: Rolf WOLTERS, Jules VALENTI, Tom GURSKI
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Patent number: 11174458Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.Type: GrantFiled: December 13, 2018Date of Patent: November 16, 2021Assignee: KOLIGO THERAPEUTICS, INC.Inventors: Rolf Wolters, Jules Valenti, Tom Gurski
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Publication number: 20190112570Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.Type: ApplicationFiled: December 13, 2018Publication date: April 18, 2019Applicant: TISSUE GENESIS, LLCInventors: Rolf WOLTERS, Jules VALENTI, Tom GURSKI
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Publication number: 20180002666Abstract: Systems and methods herein are directed towards the separation of biologic material to obtain a target cell volume and/or cell concentration for harvesting. The target volume and/or concentration of cells may be obtained through a single cycle via three chambers, or by repeated cycles through one or more chambers to dilute the digestive enzymes used in the process and concentrate the harvestable cell volume to a predetermined target.Type: ApplicationFiled: September 18, 2017Publication date: January 4, 2018Applicant: Tissue Genesis, LLCInventors: Rolf WOLTERS, Anthony YANG, Josh NELSON, Stuart K. WILLIAMS
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Publication number: 20140207103Abstract: Devices and methods are provided for processing adipose tissue with a hand-held device. This device may include a processing chamber, a cannula, a vacuum source, a digestion area, and a product cell concentration chamber.Type: ApplicationFiled: March 20, 2014Publication date: July 24, 2014Applicant: Tissue Genesis, Inc.Inventors: Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
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Publication number: 20140081237Abstract: Devices and methods are provided for aspirating adipose tissue with a portable device. This device may include a processing chamber, a cannula, a vacuum source, a filter or screen for separating connective tissue strands from adipose tissue, a digestion area, and a product cell concentration chamber.Type: ApplicationFiled: March 15, 2013Publication date: March 20, 2014Applicant: TISSUE GENESIS, INC.Inventors: Rolf Wolters, Anthony Yang, Josh Nelson, Stuart K. Williams
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Publication number: 20110301447Abstract: A process and device for detecting colon cancer by classifying and annotating clinical features in video data containing colonoscopic features by applying a probabilistic analysis to intra-frame and inter-frame relationships between colonoscopic features in spatially and temporally neighboring portions of video frames, and classifying and annotating as clinical features any of the colonoscopic features that satisfy the probabilistic analysis as clinical features. Preferably the probabilistic analysis is Hidden Markove Model analysis, and the process is carried out by a computer trained using semi supervised learning from labeled and unlabeled examples of clinical features in video containing colonoscopic features.Type: ApplicationFiled: June 7, 2011Publication date: December 8, 2011Inventors: Sun Young Park, Dustin Sargent, Ulf Peter Gustafsson, Wenjing Li, Rolf Wolters, Stephen D. Fleischer
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Publication number: 20080058593Abstract: A process for providing computer aided diagnosis from video data of an organ during an examination with an endoscope, comprising analyzing and enhancing image frames from the video and detecting and diagnosing any lesions in the image frames in real time during the examination. Optionally, the image data can be used to create a 3 dimensional reconstruction of the organ.Type: ApplicationFiled: August 21, 2007Publication date: March 6, 2008Inventors: Jia Gu, Rolf Wolters