Patents by Inventor Roman Lvovitch BOGORAD

Roman Lvovitch BOGORAD has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods for treatment of glycogen storage disease type 1A
    Patent number: 11866727
    Abstract: The present application provides materials and methods for treating a patient with Glycogen Storage Disease type 1a (GSD1a) both ex vivo and in vivo. In addition, the present application provides materials and methods for modulating the expression, function, and/or activity of the glucose-6-phosphatase, catalytic (G6PC) and/or the glucose-6-phosphatase (G6Pase) protein in a cell by genome editing.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: January 9, 2024
    Assignee: CRISPR THERAPEUTICS AG
    Inventors: Chad Albert Cowan, Roman Lvovitch Bogorad, Ante Sven Lundberg, Kirsten Leah Beaudry
  • Materials and methods for treatment of alpha-1 antitrypsin deficiency
    Patent number: 11851653
    Abstract: The present application provides materials and methods for treating a patient with Alpha-1 antitrypsin deficiency (AATD) both ex vivo and in vivo. In addition, the present application provides materials and methods for editing the SERPINA1 gene in a cell by genome editing.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: December 26, 2023
    Assignee: CRISPR THERAPEUTICS AG
    Inventors: Chad Albert Cowan, Roman Lvovitch Bogorad, Jeffrey Li, Ante Sven Lundberg, Matthias Johannes John, Jeffrey William Stebbins, Thao Thi Nguyen
  • Compositions and methods for genomic editing by insertion of donor polynucleotides
    Patent number: 11827877
    Abstract: The present disclosure provides donor polynucleotides, genome editing systems, methods, pharmaceutical compositions, and kits which correct or induce a mutation that causes Glycogen Storage Disease 1a in a genomic DNA molecule in a cell. In some embodiments the present disclosure provides donor polynucleotides comprising two strands capable of correcting a mutation that causes Glycogen Storage Disease 1a.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: November 28, 2023
    Assignee: CRISPR THERAPEUTICS AG
    Inventors: Troy Dean Carlo, Roman Lvovitch Bogorad
  • MODIFICATION OF PLANT MESSENGER PACKS WITH CHARGED LIPIDS
    Publication number: 20220304930
    Abstract: Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.
    Type: Application
    Filed: August 24, 2020
    Publication date: September 29, 2022
    Inventors: Maria Helena Christine VAN ROOIJEN, Hok Hei TAM, Maier Steve Avendano AMADO, Barry Andrew MARTIN, Ignacio MARTINEZ, Piotr Stanislaw KOWALSKI, Nataliya Vladimirovna NUKOLOVA, Jr., John Patrick CASEY, Jr., Siddharth PATEL, Roman Lvovitch BOGORAD
  • Compositions and methods for genomic editing by insertion of donor polynucleotides
    Patent number: 11332760
    Abstract: The present disclosure provides donor polynucleotides, genome editing systems, methods, pharmaceutical compositions, and kits which correct or induce a mutation that causes Glycogen Storage Disease 1a in a genomic DNA (gDNA) molecule in a cell. In some embodiments the present disclosure provides donor polynucleotides comprising two strands capable of correcting a mutation that causes Glycogen Storage Disease 1a.
    Type: Grant
    Filed: February 18, 2021
    Date of Patent: May 17, 2022
    Assignee: CRISPR THERAPEUTICS AG
    Inventors: Troy Dean Carlo, Roman Lvovitch Bogorad
  • MATERIALS AND METHODS FOR TREATMENT OF HEREDITARY HAEMOCHROMATOSIS
    Publication number: 20220008558
    Abstract: Materials and methods for treating a patient with hereditary hemochromatosis (HHC), both ex vivo and in vivo, and materials and methods for modulating the expression, function, or activity of a haemochromatosis (HFE) gene in a cell by genome editing.
    Type: Application
    Filed: July 9, 2021
    Publication date: January 13, 2022
    Inventors: Roman Lvovitch Bogorad, Chad Albert Cowan, Ante Sven Lundberg
  • Materials and methods for treatment of hereditary haemochromatosis
    Patent number: 11083799
    Abstract: Materials and methods for treating a patient with hereditary hemochromatosis (HHC), both ex vivo and in vivo, and materials and methods for modulating the expression, function, or activity of a haemochromatosis (HFE) gene in a cell by genome editing.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: August 10, 2021
    Assignee: CRISPR THERAPEUTICS AG
    Inventors: Roman Lvovitch Bogorad, Chad Albert Cowan, Ante Sven Lundberg
  • COMPOSITIONS AND METHODS FOR GENOMIC EDITING BY INSERTION OF DONOR POLYNUCLEOTIDES
    Publication number: 20210171985
    Abstract: The present disclosure provides donor polynucleotides, genome editing systems, methods, and kits which correct or induce a mutation in a gDNA.
    Type: Application
    Filed: February 18, 2021
    Publication date: June 10, 2021
    Inventors: Troy Dean CARLO, Roman Lvovitch BOGORAD
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9)-RELATED DISORDERS
    Publication number: 20200248168
    Abstract: The present application provides materials and methods for treating a patient with one or more conditions associated with PCSK9 whether ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of PCSK9 gene in a cell by genome editing.
    Type: Application
    Filed: February 15, 2018
    Publication date: August 6, 2020
    Inventors: Ante Sven LUNDBERG, Samarth KULKARNI, Lawrence KLEIN, Yvonne Sarah ARATYN, Roman Lvovitch BOGORAD, Hari Kumar PADMANABHAN
  • COMPOSITIONS AND METHODS FOR GENOMIC EDITING BY INSERTION OF DONOR POLYNUCLEOTIDES
    Publication number: 20200040362
    Abstract: The present disclosure provides donor polynucleotides, genome editing systems, methods, and kits which correct or induce a mutation in a gDNA.
    Type: Application
    Filed: June 28, 2019
    Publication date: February 6, 2020
    Inventors: Troy Dean CARLO, Roman Lvovitch BOGORAD
  • MATERIALS AND METHODS FOR TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE 1A
    Publication number: 20190382798
    Abstract: The present application provides materials and methods for treating a patient with Glycogen Storage Disease type la (GSD1a) both ex vivo and in vivo. In addition, the present application provides materials and methods for modulating the expression, function, and/or activity of the glucose-6-phosphatase, catalytic (G6PC) and/or the glucose-6-phosphatase (G6Pase) protein in a cell by genome editing.
    Type: Application
    Filed: November 7, 2016
    Publication date: December 19, 2019
    Inventors: Chad Albert COWAN, Roman Lvovitch BOGORAD, Ante Sven LUNDBERG, Kirsten Leah BEAUDRY
  • MATERIALS AND METHODS FOR TREATMENT OF HEREDITARY HAEMOCHROMATOSIS
    Publication number: 20190076551
    Abstract: Materials and methods for treating a patient with hereditary hemochromatosis (HHC), both ex vivo and in vivo, and materials and methods for modulating the expression, function, or activity of a haemochromatosis (HFE) gene in a cell by genome editing.
    Type: Application
    Filed: March 16, 2017
    Publication date: March 14, 2019
    Applicant: CRISPR Therapeutics AG
    Inventors: Roman Lvovitch Bogorad, Chad Albert Cowan, Ante Sven Lundberg
  • MATERIALS AND METHODS FOR TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY
    Publication number: 20190010490
    Abstract: The present application provides materials and methods for treating a patient with Alpha-1 antitrypsin deficiency (AATD) both ex vivo and in vivo. In addition, the present application provides materials and methods for editing the SERPINA1 gene in a cell by genome editing.
    Type: Application
    Filed: December 1, 2016
    Publication date: January 10, 2019
    Inventors: Chad Albert COWAN, Roman Lvovitch BOGORAD, Jeffrey LI, Ante Sven LUNDBERG, Matthias Johannes JOHN, Jeffrey William STEBBINS, Thao Thi NGUYEN