Patents by Inventor Romyr Dominique

Romyr Dominique has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocycles as WIP1 Inhibitors
    Publication number: 20240116910
    Abstract: The present disclosure relates to the use of substituted heterocycles for the inhibition of the activity of WIP1. Suitably, the present disclosure relates to the use of substituted heterocycles for the treatment of cancer.
    Type: Application
    Filed: September 14, 2023
    Publication date: April 11, 2024
    Inventors: Binh Vu, Romyr Dominique, Yi Chen, Hongju Li
  • Methods and compounds for restoring mutant p53 function
    Patent number: 11926632
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: March 12, 2024
    Assignee: PMV Pharmaceuticals, Inc.
    Inventors: Binh Vu, Romyr Dominique, Hongju Li, Bruce Fahr, Yi Chen
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20240043436
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: June 7, 2023
    Publication date: February 8, 2024
    Inventors: Binh Vu, Romyr Dominique, Hongju Li, Bruce Fahr, Andrew Good
  • Methods and compounds for restoring mutant p53 function
    Patent number: 11814373
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Grant
    Filed: September 22, 2020
    Date of Patent: November 14, 2023
    Assignee: PMV PHARMACEUTICALS, INC.
    Inventors: Binh Vu, Romyr Dominique, Hongju Li, Bruce Fahr, Andrew Good
  • Methods and compounds for restoring mutant p53 function
    Patent number: 11807644
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Grant
    Filed: May 11, 2021
    Date of Patent: November 7, 2023
    Assignee: PMV PHARMACEUTICALS, INC.
    Inventors: Binh Vu, Romyr Dominique, Hongju Li, Bruce Fahr, Andrew Good
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20230312539
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: June 2, 2023
    Publication date: October 5, 2023
    Inventors: Binh VU, Romyr DOMINIQUE, Hongju LI, Bruce FAHR, Andrew GOOD
  • Methods and compounds for restoring mutant p53 function
    Patent number: 11731953
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: August 22, 2023
    Assignee: PMV PHARMACEUTICALS, INC.
    Inventors: Binh Vu, Romyr Dominique, Hongju Li, Bruce Fahr, Yi Chen
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20230056253
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: June 22, 2021
    Publication date: February 23, 2023
    Inventors: Binh VU, Romyr DOMINIQUE, Hongju LI, Bruce FAHR, Yi CHEN
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20230046427
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: June 21, 2021
    Publication date: February 16, 2023
    Inventors: Binh Vu, Romyr Dominique, Hongju Li, Bruce Fahr, Yi Chen
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20230002403
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: May 11, 2021
    Publication date: January 5, 2023
    Inventors: Binh Vu, Romyr Dominique, Hongju Li, Bruce Fahr, Andrew Good
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20220315564
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: September 22, 2020
    Publication date: October 6, 2022
    Inventors: Binh VU, Romyr DOMINIQUE, Hongju LI, Bruce FAHR, Andrew GOOD
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20220213062
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: February 24, 2022
    Publication date: July 7, 2022
    Inventors: Binh Vu, Romyr Dominique, Hongju Li
  • Methods and compounds for restoring mutant p53 function
    Patent number: 11339141
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: May 24, 2022
    Assignee: PMV Pharmaceuticals, Inc.
    Inventors: Binh Vu, Romyr Dominique, Hongju Li
  • Inhibitors of bruton's tyrosine kinase
    Patent number: 11104668
    Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: August 31, 2021
    Assignees: Hoffmann-La Roche Inc., Chugai Pharmaceutical Co.
    Inventors: Francisco Javier Lopez-Tapia, Sung-Sau So, Qi Qiao, Romyr Dominique
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20210002252
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: March 16, 2020
    Publication date: January 7, 2021
    Inventors: Binh Vu, Romyr Dominique, Hongju Li
  • INHIBITORS OF BRUTON'S TYROSINE KINASE
    Publication number: 20200207741
    Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases onused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
    Type: Application
    Filed: March 11, 2020
    Publication date: July 2, 2020
    Inventors: Francisco Javier Lopez-Tapia, Sung-Sau So, Qi Qiao, Romyr Dominique
  • Methods and compounds for restoring mutant p53 function
    Patent number: 10640485
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: May 5, 2020
    Assignee: PMV PHARMACEUTICALS, INC.
    Inventors: Binh Vu, Romyr Dominique, Hongju Li
  • Inhibitors of bruton's tyrosine kinase
    Patent number: 10640491
    Abstract: This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: May 5, 2020
    Assignee: HOFFMANN-LA ROCHE INC.
    Inventors: Francisco Javier Lopez-Tapia, Sung-Sau So, Qi Qiao, Romyr Dominique
  • METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION
    Publication number: 20190119249
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Application
    Filed: October 18, 2018
    Publication date: April 25, 2019
    Inventors: Binh Vu, Romyr Dominique, Hongju Li
  • Methods and compounds for restoring mutant p53 function
    Patent number: 10138219
    Abstract: Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods to recover wild-type function to p53 mutants. The compounds of the present invention can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: November 27, 2018
    Assignee: PMV PHARMACEUTICALS
    Inventors: Binh Vu, Romyr Dominique, Hongju Li