Abstract: Provided are computing systems, methods, and platforms that automatically produce production-ready machine learning models and deployment pipelines from minimal input information such as a raw training dataset. In particular, one example computing system can import a training dataset associated with a user. The computing system can execute an origination machine learning pipeline to perform a model architecture search that selects and trains a machine learning model for the training dataset. Execution of the origination machine learning pipeline can also result in generation of a deployment machine learning pipeline configured to enable deployment of the machine learning model (e.g., running the machine learning model to produce inferences and/or optionally other tasks such as re-training and/or re-tuning the model).

Abstract: An article of protective equipment for protecting a body part of a user includes a lattice structure with a plurality of struts forming three dimensional volumetric structures. The lattice structure includes a plurality of internal layers, each internal layer having at least one different physical property from the other internal layers, wherein the plurality of internal layers comprises at least one internal layer having physical properties such that the at least one internal layer is capable of compressing more than at least one other internal layer in response to an impact to the article of protective equipment.

Abstract: An article of protective equipment for protecting a body part of a user includes a lattice structure with a plurality of struts forming three dimensional volumetric structures. The lattice structure includes a plurality of internal layers, each internal layer having at least one different physical property from the other internal layers, wherein the plurality of internal layers comprises at least one internal layer having physical properties such that the at least one internal layer is capable of compressing more than at least one other internal layer in response to an impact to the article of protective equipment.

Abstract: Disclosed is a system and method for in-situ and instantaneous measurement of a pressure gradient by real-time localized pressure measurement with two or more pressure sensors, operating with respect to blood pressure gradient across the aortic valve, or other heart valves, and associated regurgitation of blood flow due to leakage resulting from insufficient valve closure. The system includes a multi-sensor catheter, with sensors arranged along the length of the distal segment of the catheter body, spaced apart to provide simultaneous pressure measurement on either side of the valves of the heart, in addition to one or more lumina in the core of the catheter that will provide a path for introduction of diagnostic fluids which flow out through a multitude of holes in the body of the distal segment of the catheter body.

Abstract: A method and apparatus for preparing samples for imaging under cryogenic conditions or diffraction experiments under cryogenic conditions in an electron microscope. One version of the method involves: partially submerging a flat sample carrier with sample material vertically into a reservoir containing a cryogenic liquid until all areas with sample material are positioned below the surface of the cryogenic liquid; vitrifying the sample material at least one stream of cryogenic liquid to each considerable side of the sample material on the flat sample carrier at or directly below the surface of the cryogenic liquid in the reservoir; and fully submerging the flat sample carrier with the vitrified sample material into the cryogenic liquid to cool the flat sample carrier to a temperature below about 136 K. Variations of the method and various features of the apparatus are described.

Abstract: One embodiment provides a papermaking machine, which includes a wire for conveying a fiber web; a trim squirt for making a cut line in the fiber web; a machine reference; and a measurement device for measuring a distance between the cut line and the machine reference, the device comprising a laser adapted to illuminate the cut line and determine a location of the cut line for the measuring. Methods of making and using the papermaking machine are also provided.

Abstract: Disclosed is a system and method for in-situ and instantaneous measurement of a pressure gradient by means of real-time localized pressure measurement with two or more pressure sensors, operating under particular application with respect to blood pressure gradient across the aortic valve, or other heart valves, and associated regurgitation of blood flow due to leakage resulting from insufficient valve closure. The pressure gradient across a diseased valve can provide an indication for the clinical indication for therapeutic intervention, as well as performing quality control following prosthetic valve placement. The body can have a construction including at least one opening in communication with the fluid bed of the circulation of blood, connected by means of a fluid canal passing the length of the catheter in contact with the proximal exterior space for introduction of a guidewire, diagnostic fluid or other therapeutic or diagnostic catheter devices.

Abstract: Spray drying processes are used to form pharmaceutical compositions comprising a solid amorphous dispersion of a drug and a polymer.

Abstract: One embodiment provides a papermaking machine, which includes a wire for conveying a fiber web; a trim squirt for making a cut line in the fiber web; a machine reference; and a measurement device for measuring a distance between the cut line and the machine reference, the device comprising a laser adapted to illuminate the cut line and determine a location of the cut line for the measuring. Methods of making and using the papermaking machine are also provided.

Abstract: One embodiment provides a papermaking machine, which includes a wire for conveying a fiber web; a trim squirt for making a cut line in the fiber web; a machine reference; and a measurement device for measuring a distance between the cut line and the machine reference, the device comprising a laser adapted to illuminate the cut line and determine a location of the cut line for the measuring. Methods of making and using the papermaking machine are also provided.

Abstract: Methods for making particulate material include providing a first solution comprising one or more solvents and an active agent, providing a second solution comprising an antisolvent, mixing the first solution with the second solution to form a mixture, atomizing the mixture with a gas to produce droplets, and drying the droplets by directing the droplets into a chamber for removal of the solvent and the antisolvent to produce solid particles. Various apparatuses for producing particulate material in this manner are also provided.

Abstract: A conductivity measurement apparatus for measuring the conductivity of a non-aqueous sample. The conductivity measurement apparatus includes a conductivity cell which contains the sample and which is disposed within a heater block which can control the temperature of the sample and a pressure vessel which can control the surrounding pressure for the conductivity cell. A probe senses conductivity of the sample as a voltage is applied across the sample.

Abstract: One embodiment provides a papermaking machine, which includes a wire for conveying a fiber web; a trim squirt for making a cut line in the fiber web; a machine reference; and a measurement device for measuring a distance between the cut line and the machine reference, the device comprising a laser adapted to illuminate the cut line and determine a location of the cut line for the measuring. Methods of making and using the papermaking machine are also provided.

Abstract: A secondary drying process is disclosed for removing residual solvent from drug-containing particles that have been formed by solvent-based processes, the secondary drying process utilizing a combination of vacuum, agitation, and a stripping gas.

Abstract: A method of applying compression between a distal bone portion and a proximal bone portion using an orthopedic device is provided. Methods may include inserting the orthopedic device through the proximal bone portion and into the distal bone portion, where the orthopedic device includes a core and a sleeve. The method may include fastening the core to the distal bone portion and fastening the sleeve to the proximal bone portion. The method may include applying compression between the distal bone portion and the proximal bone portion. The method may include maintaining compression between the distal bone portion and the proximal bone portion with a pawl member. Methods may also include allowing for dynamic compression between the distal bone portion and the proximal bone portion after the initial compression has been achieved and maintaining the dynamic compression between the distal bone portion and the proximal bone portion with the pawl member.

Abstract: The device disclosed in this patent is a work generating device composed of magnetically transparent materials and permanent magnets, assembled to make a base, a rotor and a stator. The rotor is comprised of permanent magnet assemblies placed in a magnetically transparent material. The stator is an arrangement of permanent magnets, on one or more sides, adjacent to the linear potion of and parallel to the direction of travel of the rotor. The interaction of the rotor magnetic zone with the stator magnetic zone drives the rotor.

Abstract: The present disclosure describes simulants and methods of production thereof that imitate characteristics of known explosives, including characteristics at the microscopic and macroscopic level. For instance, the present disclosure includes a simulant with the same texture, granularity, bulk density, particle density, and porosity of a known explosive. The simulants described herein provide the macroscopic bulk physical properties and the microscopic scale properties of actual explosives.

Abstract: The present invention is a paint rim magnetic brush holder, which is an annular attachment placed on an opened paint can. The paint rim magnetic brush holder uses a rim, extended past the lateral surface of the opened paint can, to prevent stray drops of paint from hitting the opened paint can. The present invention uses a magnet and a platform to provide a convenient place to rest a wet paint brush. The wet paint brush is positioned on the platform in such a way that the wet paint brush drips into the opened paint can. The wet paint brush is held in place on the platform with the magnet. The paint rim magnetic brush holder uses a paint pourer spout to easily pour the paint in the opened paint can into the another paint can.

Abstract: An airspace risk mitigation system includes a plurality of airspace input sources, an airspace data fusion and sensor coordination system, a communications link, and a risk mitigation support system. The airspace input sources includes a radar for generating radar data for an airspace, and an Automatic Dependent Surveillance-Broadcast (ADS-B) receiver for generating additional data for the airspace. The airspace data fusion and sensor coordination system is configured to receive airspace data from the plurality of airspace input sources, correlating airspace data with new or known objects in the airspace, fusing airspace data into a common airspace data set, and generating target and system status information. The risk mitigation support system is configured to calculate a risk associated with aircraft operation in the airspace as a function of the target and system status information.

Abstract: An intramedullary device for repairing defects of a bone is provided. The intramedullary device is configured to be inserted into the medullary canal of a bone and includes a stud protruding from the end. The stud includes a portion that is tapered from a first cross-sectional area to a second cross-sectional where the second cross-sectional area is smaller than that of the first cross-sectional area and the second cross-sectional area defines a region of concentrated stress. The stud also includes a portion configured to engage the internal threads of a fastener retained within an intramedullary device assembly, such as a guide member adapter. The external threads of the stud engage the internal threads of the fastener to secure the intramedullary device to the intramedullary assembly when a first torque is applied to the fastener.