Abstract: Signal processing is used to detect transient signals in the presence of noise. Two embodiments are disclosed. In both embodiments, the time series from a remote sensor is broken into a number of short time series. The power spectrum of each short time series are then calculated along with the mean noise level. The moments of each peak in every power spectrum are calculated and the peak with the largest power selected from each power spectrum. A histogram of the moments from these selected peaks is generated and normalized to become a measured PDF. In addition, a pre-determined PDF is derived, in the same method as above, from theoretically calculated noise, numerically simulated noise, or measured noise. Comparison between the measured and pre-determined PDF's establish the detection of a transient signal. The first embodiment compares the area between the measured and pre-determined PDF's against a threshold to determine detection.

Abstract: A glucuronide metabolite of tigecycline, and its corresponding epimer, have been identified in humans treated with tigecycline. Mass spectral data have been used to identify these structures.

Abstract: Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3, R4, Rx, Ry, and n are as defined herein. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.

Abstract: Compounds of formula I are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. or pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3, R4, Rx, Ry, and n are as defined herein. Such compounds, and compositions thereof, are useful for treating a variety of central nervous system disorders such as schizophrenia.

Abstract: A glucuronide metabolite of tigecycline, and its corresponding epimer, have been identified in humans treated with tigecycline. Mass spectral data have been used to identify these structures.

Abstract: The invention relates to metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof. Specifically, the invention relates to compounds of formula I wherein the various substituents are defined herein. The invention also provides pharmaceutical compositions including compounds of formula I, methods of making such compounds, and methods of using such compounds.

Abstract: Improved methods and apparatus are provided for sealing at the uppermost end of a casing string to provide circulation from adjacent the lower end of the casing string and into a well bore to enable the casing string to be more easily lowered into the well bore. A casing circulator is provided for lowering into the uppermost end of the casing string above the rig floor, and for sealing with an interior surface of the uppermost end of the casing string. An external sealing member of the casing circulator may be moved axially with respect to an inner packer tube, thereby allowing the sealing member to become inflated while also enabling fluid to pass through the casing circulator and into the casing string. The techniques of the present invention may also be used to fill the casing string as it is lowered into the well bore.