Patents by Inventor Ronald Beavis

Ronald Beavis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • peptides for bacterial interference
    Patent number: 7419954
    Abstract: The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: September 2, 2008
    Assignee: The Rockefeller University
    Inventors: Tom W. Muir, Patricia Mayville, Richard P. Novick, Ronald Beavis, Guangyong Ji
  • Method for detecting post-translation modifications of peptides
    Patent number: 7341874
    Abstract: This invention provides for novel methods of identifying covalent modifications of an amino acid residue in a polypeptide chain by detecting mass differences.
    Type: Grant
    Filed: March 2, 2004
    Date of Patent: March 11, 2008
    Assignees: The Rockefeller University, The Scripps Research Institute
    Inventors: Brian T. Chait, Ronald Beavis, Rong Wang, Stephen B. H. Kent
  • Novel Staphylococcus peptides for bacterial interference
    Publication number: 20070185016
    Abstract: The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
    Type: Application
    Filed: August 25, 2005
    Publication date: August 9, 2007
    Inventors: Tom Muir, Patricia Mayville, Richard Novick, Ronald Beavis, Guangyong Ji
  • Staphylococcus peptides for bacterial interference
    Patent number: 6953833
    Abstract: The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
    Type: Grant
    Filed: December 27, 2001
    Date of Patent: October 11, 2005
    Assignees: The Rockefeller University, New York University
    Inventors: Tom W. Muir, Patricia Mayville, Richard P. Novick, Ronald Beavis, Guangyong Ji
  • Method for detecting post-translational modification of peptides
    Publication number: 20050153454
    Abstract: Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
    Type: Application
    Filed: December 1, 2004
    Publication date: July 14, 2005
    Applicants: The Rockefeller University, The Scripps Research Institute
    Inventors: Brian Chait, Ronald Beavis, Rong Wang, Stephen Kent
  • Method for detecting post-translation modifications of peptides
    Publication number: 20040265944
    Abstract: Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
    Type: Application
    Filed: March 2, 2004
    Publication date: December 30, 2004
    Applicants: The Rockefeller University, The Scripps Research Institute
    Inventors: Brian T. Chait, Ronald Beavis, Rong Wang, Stephen B. H. Kent
  • Method and product for the sequence determination of peptides using a mass spectrometer
    Patent number: 6750061
    Abstract: Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: June 15, 2004
    Assignees: The Rockefeller University, The Scripps Research Institute
    Inventors: Brian T. Chait, Ronald Beavis, Rong Wang, Stephen B. H. Kent
  • Blocking expression of virulence factors in S. aureus
    Publication number: 20030078378
    Abstract: This invention provides peptides which inhibit agr transcription in S. aureus and thereby block the expression of virulence factors in S. aureus, pharmaceutical compositions comprising these peptides, as well as methods for treating or preventing an infection or disease caused by S. aureus using the peptides of the present invention.
    Type: Application
    Filed: July 23, 2002
    Publication date: April 24, 2003
    Inventors: Richard P. Novick, Guangyong Ji, Ronald Beavis
  • Method and product for the sequence determination of peptides using a mass spectrometer
    Publication number: 20030059952
    Abstract: Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
    Type: Application
    Filed: April 5, 2001
    Publication date: March 27, 2003
    Inventors: Brian T. Chait, Ronald Beavis, Rong Wang, Stephen B.H. Kent
  • Blocking expression of virulence factors in S. aureus
    Patent number: 6447786
    Abstract: This invention provides peptides which inhibit agr transcription in S. aureus and thereby block the expression of virulence factors in S. aureus, pharmaceutical compositions comprising these peptides, as well as methods for treating or preventing an infection or disease caused by S. aureus using the peptides of the present invention.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: September 10, 2002
    Assignee: New York University
    Inventors: Richard P. Novick, Guangyong Ji, Ronald Beavis
  • Novel staphylococcus peptides for bacterial interference
    Publication number: 20020077453
    Abstract: The present invention provides a cyclic peptide comprising the structure: 1
    Type: Application
    Filed: December 27, 2001
    Publication date: June 20, 2002
    Inventors: Tom W. Muir, Patricia Mayville, Richard P. Novick, Ronald Beavis, Guangyong Ji
  • Staphylococcus peptides for bacterial interference
    Patent number: 6337385
    Abstract: The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)—Z—X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10.
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: January 8, 2002
    Assignees: The Rockefeller University, New York University
    Inventors: Tom W. Muir, Patricia Mayville, Richard P. Novick, Ronald Beavis, Guangyong Ji
  • Method and product for the sequence determination of peptides using a mass spectrometer
    Patent number: 6271037
    Abstract: Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.
    Type: Grant
    Filed: June 24, 1996
    Date of Patent: August 7, 2001
    Assignees: The Rockefeller University, The Scripps Research Institute
    Inventors: Brian T. Chait, Ronald Beavis, Rong Wang, Stephen B. H. Kent