Patents by Inventor Ronald F. Sprouse

Ronald F. Sprouse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccine and serum for endotoxin associated disease immunization and treatment, detoxified endotoxin, and bacterial mutant
    Patent number: 5961985
    Abstract: A combination vaccine, with methods of preparation and treatment, for protection against Gram negative bacterial diseases. The vaccine includes a killed suspension of a bacterial mutant from the taxonomic family Enterobacteriaceae, a B-lymphocyte proliferating immune modulator, and a protein and lipid binding adjuvant. A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with the combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis. The immune modulator is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.
    Type: Grant
    Filed: May 14, 1997
    Date of Patent: October 5, 1999
    Assignee: The Curators of the University of Missouri
    Inventors: Ronald F. Sprouse, Harold E. Garner
  • Vaccine and serum for endotoxin associated disease immunization and treatment, detoxified endotoxin, and bacterial mutant
    Patent number: 5641492
    Abstract: A combination vaccine, with methods of preparation and treatment, for protection against Gram negative bacterial diseases. The vaccine includes a killed suspension of a bacterial mutant from the taxonomic family Enterobacteriaceae, a B-lymphocyte proliferating immune modulator, and a protein and lipid binding adjuvant. A hyperimmune serum for treating diseased animals is prepared by vaccinating a donor animal with the combination vaccine and then preparing clot serum containing antigen specific antibodies. The mutant is ATCC No. 53000 and is produced by ionizing radiation of Salmonella enteritidis. The immune modulator is a detoxified extract of lipopolysaccharide and is useful with many antigens to enhance primary immune response.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: June 24, 1997
    Assignee: The Curators of the University of Missouri
    Inventors: Ronald F. Sprouse, Harold E. Garner