Patents by Inventor Ronald Flannagan
Ronald Flannagan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080108127Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.Type: ApplicationFiled: December 5, 2007Publication date: May 8, 2008Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANYInventors: Andre Abad, Ronald Flannagan, Rafael Hermann, Albert Lu, Billy McCutchen, James Presnail, Janet Rice, James Wong, Cao-Guo Yu
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Publication number: 20080016596Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, novel polynucleotides and the pesticidal polypeptides they encode are provided. Methods of using the novel polynucleotides and pesticidal polypeptides of the invention to protect a plant from an insect pest are further provided. Particular embodiments of the invention provide pesticidal compositions and formulations, DNA constructs, and transformed plants, plant cells, and seeds.Type: ApplicationFiled: September 12, 2007Publication date: January 17, 2008Inventors: Andre Abad, Ronald Flannagan, Billy McCutchen, Cao Yu
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Publication number: 20070245428Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, novel polynucleotides and the pesticidal polypeptides they encode are provided. Methods of using the novel polynucleotides and pesticidal polypeptides of the invention to protect a plant from an insect pest are further provided. Particular embodiments of the invention provide pesticidal compositions and formulations, DNA constructs, and transformed plants, plant cells, and seeds.Type: ApplicationFiled: April 14, 2006Publication date: October 18, 2007Inventors: Andre Abad, Ronald Flannagan, Billy McCutchen, Cao Yu
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Publication number: 20070243536Abstract: Methods and compositions for identifying novel pesticidal gene homologues are provided. Specifically, the methods of the invention comprise systematically designing oligonucleotide primers that are specific for a pesticidal gene of interest and performing successive rounds of PCR amplification of nucleic acid material from a microorganism, particularly a Bacillus thuringiensis strain, to identify novel homologues of known pesticidal genes. Oligonucleotide primers that can be used to practice the present methods are further disclosed.Type: ApplicationFiled: April 14, 2006Publication date: October 18, 2007Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Andre Abad, Ronald Flannagan, Bin Hu, Billy McCutchen, Xiaofeng Yang, Cao Yu
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Publication number: 20070245427Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, novel polynucleotides and the pesticidal polypeptides they encode are provided. Methods of using the novel polynucleotides and pesticidal polypeptides of the invention to protect a plant from an insect pest are further provided. Particular embodiments of the invention provide pesticidal compositions and formulations, DNA constructs, and transformed plants, plant cells, and seeds.Type: ApplicationFiled: April 14, 2006Publication date: October 18, 2007Inventors: Andre Abad, Ronald Flannagan, Billy McCutchen, Cao Yu
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Publication number: 20060288448Abstract: Compositions and methods for protecting a plant from an insect pest are provided. Nucleic acid molecules encoding insect protoxins or insect toxins modified to comprise at least one proteolytic activation site that is sensitive to an insect gut protease are provided. Cleavage of a modified insect protoxin at the proteolytic activation site by an insect gut protease produces an active insect toxin in the gut of the insect pest. Cleavage of a modified insect toxin of the invention at a proteolytic activation site results in the production of an active insect toxin in the insect gut that displays improved pesticidal activity relative to the insect toxin that lacks the proteolytic activation site. Methods of using the modified insect protoxin and modified insect toxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided.Type: ApplicationFiled: June 7, 2006Publication date: December 21, 2006Applicants: Pioneer Hi-Bred International, Inc., E.I du PONT de NEMOURS and COMPANYInventors: Andre Abad, Gary Chun, Ronald Flannagan, Rafael Herrmann, Albert Lu, Janet Rice, Eric Schepers
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Publication number: 20060241044Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.Type: ApplicationFiled: June 21, 2006Publication date: October 26, 2006Applicants: E.I. du PONT de NEMOURS and COMPANYInventors: Ronald Flannagan, Andre Abad
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Publication number: 20060242733Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.Type: ApplicationFiled: June 21, 2006Publication date: October 26, 2006Applicants: E.I. du PONT de NEMOURS and COMPANYInventors: Ronald Flannagan, Andre Abad
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Publication number: 20060241043Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.Type: ApplicationFiled: June 21, 2006Publication date: October 26, 2006Applicants: E.I.du PONT de NEMOURS and COMPANYInventors: Ronald Flannagan, Andre Abad
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Publication number: 20060236424Abstract: The present invention relates to methods of designing nucleic acid molecules for improved expression of the encoded polypeptides in plants. In such methods, codon usage frequencies are biased towards codon usage frequencies of a plant virus, group of plant viruses, or a subset of nucleic acid molecules therefrom. In preferred embodiments, the encoded polypeptide affects the phenotype of the plant. The invention also pertains to nucleic acid molecules encoding insecticidal polypeptides wherein the nucleic acid molecules have been designed to have plant virus codon-biased. The invention also pertains to transgenic plants and progeny thereof with increased expression of insecticidal polypeptides for improved resistance to insects and other pests that are detrimental to plants of agricultural value.Type: ApplicationFiled: April 5, 2006Publication date: October 19, 2006Inventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Albert Lu, Billy McCutchen, Carl Simmons
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Publication number: 20060194314Abstract: The invention relates to Bt toxin resistance management. The invention particularly relates to the isolation and characterization of nucleic acid and polypeptides for a novel Bt toxin receptor. The nucleic acid and polypeptides are useful in identifying and designing novel Bt toxin receptor ligands including novel insecticidal toxins.Type: ApplicationFiled: May 8, 2006Publication date: August 31, 2006Applicant: Pioneer Hi-Bred International, Inc.Inventors: Ronald Flannagan, Terry Meyer
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Publication number: 20050262587Abstract: The invention relates to Bt toxin resistance management. The invention particularly relates to the isolation and characterization of nucleic acid and polypeptides for a novel Bt toxin receptor. The nucleic acid and polypeptides are useful in identifying and designing novel Bt toxin receptor ligands including novel insecticidal toxins.Type: ApplicationFiled: July 29, 2005Publication date: November 24, 2005Applicant: Pioneer Hi-Bred International, Inc.Inventors: Ronald Flannagan, John Mathis, Terry Meyer
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Publication number: 20050261188Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.Type: ApplicationFiled: April 18, 2005Publication date: November 24, 2005Applicant: E.I. du PONT de NEMOURS and COMPANYInventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Theodore Kahn, Albert Lu, Billy McCutchen, James Presnail, James Wong, Cao-Guo Yu
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Publication number: 20050261483Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests. The invention further provides mutagenized nucleic acids that have been modified to encode pesticidal polypeptides such as endotoxins having improved pesticidal activity and/or altered pest specificity. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins that may be optimized as well as pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.Type: ApplicationFiled: February 15, 2005Publication date: November 24, 2005Applicant: E.I. duPont de Nemours and CompanyInventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Theodore Kahn, Albert Lu, Billy McCutchen, James Presnail, James Wong, Cao-Guo Yu
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Publication number: 20050260675Abstract: The invention relates to Bt toxin resistance management. The invention particularly relates to the isolation and characterization of nucleic acid and polypeptides for a novel Bt toxin receptor. The nucleic acid and polypeptides are useful in identifying and designing novel Bt toxin receptor ligands including novel insecticidal toxins.Type: ApplicationFiled: July 29, 2005Publication date: November 24, 2005Applicant: Pioneer Hi-Bred International, Inc.Inventors: Ronald Flannagan, John Mathis, Terry Meyer
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Publication number: 20050166284Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.Type: ApplicationFiled: December 22, 2004Publication date: July 28, 2005Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANYInventors: Andre Abad, Ronald Flannagan, Rafael Herrmann, Albert Lu, Billy McCutchen, James Presnail, Janet Rice, James Wong, Cao-Guo Yu
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Publication number: 20050138685Abstract: The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding ?-endotoxins having pesticidal activity against insect pests, including Lepidoptera. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant pests.Type: ApplicationFiled: December 21, 2004Publication date: June 23, 2005Applicant: E.I du Pont de Nemours and CompanyInventors: Ronald Flannagan, Andre Abad