Patents by Inventor Ronald Gayler

Ronald Gayler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ALPHA CONOTOXIN PEPTIDES WITH ANALGESIC PROPERTIES
    Publication number: 20090197810
    Abstract: This invention relates to novel ?-conotoxin-like peptides comprising the following amino acid sequence (SEQ ID NO:10): Xaa1-Cys-Cys-Ser-Xaa2-Xaa3-Xaa4-Cys-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Cys-NH2 in which Xaa1 is Gly or Asp; Xaa3 is Pro, Hyp or Glu; each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid; Xaa9 is Pro, Hyp or Glu; Xaa10 is Asp, Glu or ?-carboxyGlu; Xaa11 is optionally absent; and the C-terminus is optionally amidated, with the proviso that the peptide is not ?-conotoxin Ep1 or ?-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.
    Type: Application
    Filed: March 24, 2008
    Publication date: August 6, 2009
    Inventors: Bruce Grayson LIVETT, Zeinab Khalil, Kenwyn Ronald Gayler, John Geoffrey Down, David William Sandall, David Anthony Keays
  • ?-conotoxin peptides with analgesic properties
    Patent number: 7348400
    Abstract: This invention relates to novel ?-conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C—NH2 in which Xaa1 is G or D; Xaa3 is proline, hydroxyproline or glutamine; each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid; Xaa9 is proline, hydroxyproline or glutamine; Xaa10 is aspartate, glutamate or ?-carboxyglutamate; Xaa11 is optionally absent; and the C-terminus is optionally amidated, with the proviso that the peptide is not ?-conotoxin Ep1 or ?-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: March 25, 2008
    Inventors: Bruce Grayson Livett, Zeinab Khalil, Kenwyn Ronald Gayler, John Geoffrey Down, David William Sandall, David Anthony Keays
  • Treatment of substances
    Patent number: 4490287
    Abstract: A process and apparatus are disclosed for the treatment of a substance contained in a solution of a slurry.The solution or slurry is treated in a fluidized bed to give a fusible dried product by use of microwave radiation.The fusible dried product can be heated and fused by use of microwave radiation.
    Type: Grant
    Filed: March 15, 1982
    Date of Patent: December 25, 1984
    Assignee: United Kingdom Atomic Energy Authority
    Inventors: William H. Hardwick, Ronald Gayler
  • Treatment of substances
    Patent number: 4221680
    Abstract: A process and apparatus are disclosed for the treatment of a substance contained in a solution or a slurry.The solution or slurry can be treated to give a fusible dried product by use of microwave radiation.The fusible dried product can be heated and fused by use of microwave radiation.
    Type: Grant
    Filed: July 18, 1977
    Date of Patent: September 9, 1980
    Assignee: United Kindgom Atomic Energy Authority
    Inventors: William H. Hardwick, Ronald Gayler