Abstract: Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).

Abstract: In a fastener-driving tool, such as a powder-actuated tool, a nosepiece has an aperture, through which a fastener can be axially driven. A shuttle has a passageway to receive the fastener, as guided by a flexible tube, in a fastener-receiving position of the shuttle. A shuttle-moving mechanism is used to move the shuttle from the fastener-receiving position into a fastener-delivery position. A driving mechanism enables the fastener to be axially driven from the passageway, through the aperture, in the delivery position of the shuttle. A magnet or a spring, such as a torsional spring having an arm to engage the fastener, is used to retain the fastener in a pre-driving position. As a stand-up tool, the tool has a primary trigger and a secondary trigger, which enables the primary trigger to be remotely actuated.

Abstract: In a fastener-driving tool, such as a powder-actuated tool, a nosepiece has an aperture, through which a fastener can be axially driven. A shuttle has a passageway to receive the fastener, as guided by a flexible tube, in a fastener-receiving position of the shuttle. A shuttle-moving mechanism is used to move the shuttle from the fastener-receiving position into a fastener-delivery position. A driving mechanism enables the fastener to be axially driven from the passageway, through the aperture, in the delivery position of the shuttle. A magnet or a spring, such as a torsional spring having an arm to engage the fastener, is used to retain the fastener in a pre-driving position. As a stand-up tool, the tool has a primary trigger and a secondary trigger, which enables the primary trigger to be remotely actuated.

Abstract: In a fastener-driving tool, such as a powder-actuated tool, a nosepiece has an aperture, through which a fastener can be axially driven. A shuttle has a passageway to receive the fastener, as guided by a flexible tube, in a fastener-receiving position of the shuttle. A shuttle-moving mechanism is used to move the shuttle from the fastener-receiving position into a fastener-delivery position. A driving mechanism enables the fastener to be axially driven from the passageway, through the aperture, in the delivery position of the shuttle. A magnet or a spring, such as a torsional spring having an arm to engage the fastener, is used to retain the fastener in a pre-driving position. As a stand-up tool, the tool has a primary trigger and a secondary trigger, which enables the primary trigger to be remotely actuated.

Abstract: A flashing system including a fiber reinforced silicone sheet having substantial vapor permeability and water resistance is pre-assembled with a pair of ductile non-corrodable strips embedded in edges of the sheet. The system also includes the use of headed self-drilling fasteners to facilitate installation in metal buildings and to create a seal at the point of fastening.