Patents by Inventor Ronald J. Nachman
Ronald J. Nachman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220039395Abstract: The invention relates to CAP2b analogues having activity against hemipteran insects such as aphids, and their use as insect control agents (e.g. insecticides) and plant protection agents. In particular it has been found that a known CAP2b analogue designated 1895, and new CAP2b analogues including molecules designated 2129, 2315, 2316 and 2320, have activity against hemipteran insects and so find use for control of hemipteran insects and plant protection.Type: ApplicationFiled: December 3, 2019Publication date: February 10, 2022Inventors: Lucy ALFORD, Julian A. DOW, Shireen A. DAVIES, Ronald J. NACHMAN
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Patent number: 7208476Abstract: Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acid residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.Type: GrantFiled: September 10, 2003Date of Patent: April 24, 2007Assignee: The United States of America, as represented by the Secretary of AgricultureInventors: Ronald J. Nachman, Peter E. A. Teal, Christopher S. Garside, Stephen S. Tobe
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Patent number: 7129226Abstract: Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acid residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.Type: GrantFiled: September 10, 2003Date of Patent: October 31, 2006Assignee: The United States of America as represented by the Secretary of ArgricultureInventors: Ronald J. Nachman, Peter E. A. Teal, Christopher S. Garside, Stephen S. Tobe
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Patent number: 7078384Abstract: Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acid residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.Type: GrantFiled: March 10, 2003Date of Patent: July 18, 2006Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Ronald J. Nachman, Peter E. A. Teal, Christopher S. Garside, Stephen S. Tobe
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Publication number: 20040229812Abstract: Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acid residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.Type: ApplicationFiled: September 10, 2003Publication date: November 18, 2004Applicant: The United States of America, as represented by the Secretary of AgricultureInventors: Ronald J. Nachman, Peter E. A. Teal, Christopher S. Garside, Stephen S. Tobe
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Publication number: 20040039159Abstract: Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acid residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.Type: ApplicationFiled: September 10, 2003Publication date: February 26, 2004Inventors: Ronald J. Nachman, Peter E.A. Teal, Christopher S. Garside, Stephen S. Tobe
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Patent number: 6664371Abstract: Novel pseudopeptide analogs of the insect allatostain neuropeptide family which possess biological activity mimicking that of the naturally ocurring neuropepetides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphipilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acids residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.Type: GrantFiled: January 19, 2001Date of Patent: December 16, 2003Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Ronald J. Nachman, Peter E. A. Teal, Christopher S. Garside, Stephen S. Tobe
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Publication number: 20030161857Abstract: Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acid residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.Type: ApplicationFiled: March 10, 2003Publication date: August 28, 2003Applicant: United States of America, as represented by the Secretary of AgricultureInventors: Ronald J. Nachman, Peter E. A. Teal, Christopher S. Garside, Stephen S. Tobe
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Patent number: 6207643Abstract: Novel pseudopeptide analogs of the insect allatostatin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. Furthermore, by substituting sterically hindered amino acids or aromatic acids for any or all of the first, third or fifth amino acid residues of the allatostatin C-terminal pentapeptide, analogs may be produced which are resistant to degradation by insect peptidases while still retaining biological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmental processes normally regulated by allatostatins in insects.Type: GrantFiled: November 13, 1998Date of Patent: March 27, 2001Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Ronald J. Nachman, Peter E. A. Teal, Christopher S. Garside, Stephen S. Tobe
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Patent number: 5795857Abstract: Novel pseudopeptide analogs of the insect pyrokinin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By addition of a hydrophobic moiety to an active portion of the pyrokinin peptides, analogs are produced which exhibit an overall amphiphilic nature and which are capable of penetrating the insect cuticle while still retaining biological activity. The analogs may be used for insect control by disrupting the reproductive, developmental, and/or digestive processes normally regulated by pryrokinins in insects.Type: GrantFiled: August 22, 1996Date of Patent: August 18, 1998Assignee: The United States of America as represented by the Secretary of the AgricultureInventors: Ronald J. Nachman, Peter E. A. Teal, Grant Mark Holman
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Patent number: 5792466Abstract: Novel pseudopeptide analogs of the insect kinin neuropeptide family which possess biological activity mimicking that of the naturally occurring neuropeptides are disclosed. By substituting a sterically hindered amino acid which is compatible with a turn conformation, for the Xaa.sup.2 amino acid of the insect kinin C-terminal pentapeptide (i.e. Ser, Pro, or Ala), analogs are produced which exhibit resistance to degradation by angiotensin converting enzyme (ACE) while still retaining biological activity. The analogs may be used for insect control by disrupting the diuretic and/or myotropic activity in insects.Type: GrantFiled: December 13, 1996Date of Patent: August 11, 1998Assignee: The United States of America, as represented by the Secretary of AgricultureInventors: Ronald J. Nachman, Grant Mark Holman