Abstract: This disclosure provides a method for treating a subject afflicted with a tumor or a cancer, wherein the method comprises administering to the subject therapeutically effective amounts of an anti-TIM3 antibody, alone or in combination with an inhibitor of the PD-1 signaling pathway (e.g., anti-PD-1 antibody). In some embodiments, the antibody is administered as a flat dose or a weight-based dose.

Abstract: The liner packer assembly and method includes a liner packer having a tubular body with an aperture for the flow of wellbore fluids. A packing element is movably disposed on the tubular body between an open position on one side of the aperture for allowing wellbore fluids to flow through the aperture to a closed position on the other side of the aperture for closing flow through the aperture and for packing off the annulus between the packer and outer casing. During the cementing operation, drilling fluids and cement are allowed to flow through the annular area formed by the packer and outer casing and also flow through the aperture in the tubular body of the packer and up the inside diameter or inner annular area formed by the packer and inner tubular string. The inner and outer annular areas around packer approximately the flow area below the packer between the inner tubular string and the outer casing.