Abstract: A respiratory system includes a heatable conduit configured to convey the breathable gas. The heatable conduit has a first end configured to be fluidly coupled to a flow generator or a humidifier and a second end configured to be fluidly coupled to the patient interface and be electrically connected to the patient interface. A grouping of wires includes a pair of heating wires and a transfer wire extending along the length of the heatable conduit between the first end and the second end of the heatable conduit. A sensing device extends from an interior surface of the heatable conduit. A sensing circuit is electrically connected to the sensing device and the transfer wire. The transfer wire is configured to be electrically connected to the patient interface and to transfer power to the patient interface. The transfer wire is further configured to receive data from the patient interface.

Abstract: A respiratory treatment apparatus provides respiratory treatment with improved power management control to permit more efficient power consumption and power supply units, such as battery powered operation. In one embodiment, power management prioritizes the flow generator (104) over other accessories such as the heating elements (111, 135) of a humidifier (112) and/or a delivery tube. The flow generator may control operations of the heating elements as a function of a detected respiratory cycle. For example, the timing of operation of the heating elements may be interleaved with the portion of an inspiratory phase of the respiratory cycle to permit the flow generator to operate during a peak power operation without a power drain or with a lower power drain from these components. Operations of distinct sets of components of the system (e.g., different heating elements) may also be interleaved to prevent simultaneous peak power operations.

Abstract: An EMG-based control system is disclosed. The system includes an EMG sensor that streams data to a device. A neural network executed by the device decodes muscle activity into a two-dimensional continuous control signal. A network-based calibration routine optimizes the neural network to decode natural movements of the user.

Abstract: An application specific integrated circuit (ASIC) can drive semiconductor devices, such as, radio frequency amplifiers, switches, etc. The ASIC can include a supply and reference voltage generation circuit, a digital core, a clock generator, a plurality of analog-to-digital converters, low and high-speed communications interfaces, drain and gate sensing circuits (that can include one or more current sense amplifiers), and a gate driver circuit. The ASIC can be a low voltage semiconductor integrated circuit.

Abstract: A method of using a sterilization wrap system including a permeable material having barrier properties and having a first surface and a second opposing surface, the exterior panel being substantially opaque or having a first level of translucence, and an interior panel including a permeable material having barrier properties and having a first surface and a second opposing surface, the interior panel having a level of translucence that is higher than the translucence of the exterior panel, the panels being joined together over at least a portion of their surfaces. Also disclosed is inspection of the sterilization wrap system for exterior panel breaches by looking for light passing through a panel facing the viewer.

Abstract: A collapsible humidifier reservoir assembly is configured to humidify a flow of pressurized respiratory gas. The humidifier reservoir assembly includes a bottom portion comprising a heat conducting base plate and a top portion that is releasably secured to the bottom portion. A seal is sandwiched between the top and bottom portions. An air inlet is configured to receive the flow of pressurized respiratory gas, and an air outlet is configured to discharge the flow of pressurized respiratory gas from the humidifier reservoir assembly. The bottom and top portions are formed from a flexible material, and the humidifier reservoir is configured to expand upon being filled with fluid.

Abstract: A system and a method are disclosed for receiving a request for a user to perform a plurality of activities with respect to a secure document, a given activity of the plurality activities being assigned based on a known parameter of the user. The system transmits the request to the user, and responsive to detecting an interaction with the request, determines that the known parameter has changed. The system responsively determines requirements for performing the plurality of activities based on a replacement parameter of the user, determines a replacement activity based on the requirements, and transmits a new request to the user, the new request replacing the given activity with the replacement activity.

Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Abstract: This disclosure relates generally to corrugated pipe, and more particularly to corrugated pipe with an outer wrap. In one embodiment, a pipe includes an axially extended bore defined by a corrugated outer wall having axially adjacent, outwardly-extending corrugation crests, separated by corrugation valleys. The pipe also includes an outer wrap applied to the outer wall. The outer wrap may include fibers and plastic. The outer wrap may span the corrugation crests producing a smooth outer surface.

Abstract: An in-line surface drain may comprise a cylindrical frame and a plurality of concentric rings coupled to the cylindrical frame. The plurality of concentric rings may be configured to protrude outward from a bottom external surface of the cylindrical frame, and the diameters of the plurality of concentric rings may be different. At least one of the plurality of concentric rings may be configured to detachably accommodate a riser pipe.

Abstract: A razor blade including: a substrate having a tip portion including a tip region, a blade body including a base, and first and second outer sides disposed opposite a split line of the substrate, in which the first and second outer sides converge at a tip, the first outer side comprises a first coating disposed substantially thereon and extending from the tip region toward the base, and a first portion of the second outer side is substantially free of any coating, the first portion extending from the tip region toward the base or being spaced apart from the tip region and the base. Also provided is a method of coating the razor blade.

Abstract: Timing adjustment for accurate zero-crossing determination includes obtaining time offset(s) representing amounts of time between (i) zero-crossings of an input signal waveform, representative of an input AC waveform, input to a zero-crossing detector circuit and (ii) corresponding transitions of an output signal from an output of the circuit to a microcontroller, and determining times of the zero-crossings of the input AC waveform, which includes determining times of the corresponding transitions as detected by the microcontroller and adjusting the determined times using the time offset(s) to produce the times of the zero-crossings of the input AC waveform. In another aspect, input AC frequency is determined by determining pulse width(s) of pulse(s) of the output signal, and adjusting a half-cycle time corresponding to the pulse width(s) using the time offset(s) to provide a duration of half-cycles of the input AC waveform and inform a frequency of the input AC waveform.

Abstract: A method of using a sterilization wrap system including a permeable material having barrier properties and having a first surface and a second opposing surface, the exterior panel being substantially opaque or having a first level of translucence, and an interior panel including a permeable material having barrier properties and having a first surface and a second opposing surface, the interior panel having a level of translucence that is higher than the translucence of the exterior panel, the panels being joined together over at least a portion of their surfaces. Also disclosed is inspection of the sterilization wrap system for exterior panel breaches by looking for light passing through a panel facing the viewer.

Abstract: Razors cartridges including a guard, a cap, and at least two blades with parallel sharpened edges located between the guard and cap are provided. The first blade has a first color and a second blade has a second color, where the first color is different than the second color. The blade color corresponds to an attribute of the blade (e.g., low cut force) that the color is disposed on or an attribute of the razor cartridge (e.g., sensitive skin). The color of the blade corresponds to a target user of the razor cartridge (e.g., male or female). The first blade defines a blade edge near or nearest the guard and a second blade defines a blade edge near or nearest the cap.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: A humidifier for humidification of air to be delivered to a patient's airways may include a humidification chamber, a reservoir and a water delivery mechanism. The humidification chamber may include a water retention feature such as a wick, a heating element for heating the humidification chamber, and an air flow baffle configured to promote humidification. The humidifier may be further configured to execute one or more algorithms, for example to determine a condition of the humidifier and/or to mitigate any detected faults. In some forms, the humidifier may also comprise algorithms for controlling one or more components of the humidifier.

Abstract: Particular embodiments described herein provide for an electronic device that can be configured to allow for the mitigation of ransomware. For example, the system can determine that an application begins to execute, determine that the application attempts to modify a file, determine a file type for the file, and create a security event if the application is not authorized to modify the file type. In another example, the system determines an entropy value between the file and the attempted modification of the file, and create a security event if the entropy value satisfies a threshold or determine a system entropy value that includes a rate at which other files on the system are being modified by the application, and create a security event if the system entropy value satisfies a threshold.

Abstract: A system and method for implementing and manufacturing a hierarchy system for use with a TMCCC-containing electrically-conductive structure (e.g., an electrode) as well as methods for use and manufacturing of such structures and electrochemical cells including these devices. Structures and methods include a coordination complex having LxMyNzTia1Va2Cra3Mna4Fea5Coa6Nia7Cua8Zna9Caa10Mga11[R(CN)6]b (H2O)c. The method includes binding electrochemically active material to produce a hierarchical structure, the hierarchical structure having a plurality of primary crystallites having a size D1, the plurality of these primary crystallites agglomerated into a set of agglomerates each agglomerate having a size D2>D1.

Abstract: An online document system manages access to features within the online document system. The online document system may identify a first entity and a second entity associated with the first entity. The online document system may apply a trained machine learning model to a characteristic of at least one of the first entity or the second entity to identify one or more features within an online document system to recommend. The machine learning model may have been trained using feature training data describing one or more characteristics of a plurality of entities and describing historical activity associated with a usage of a plurality of features within the online document system by the plurality of entities. The online document system may output an indication of the one or more identified features to the first entity.