Abstract: Provided herein are methods of identifying genomic region(s) predictive of an outcome of treatment with a cell therapy and/or of a phenotype of function of the cells. In some embodiments, the methods include epigenetic and/or epigenomic analyses of the cells in connection with methods for preparing engineered cells for cell therapy and/or predicting response to a cell therapy, e.g., engineered cells for cell therapy. In some embodiments, the methods include steps to assess, characterize and analyze changes or modifications in an epigenetic property of gene region or regions, such as chromatin accessibility, nucleosome occupancy, histone modification, spatial chromosomal conformation, transcription factor occupancy and/or DNA methylation. In some embodiments, the epigenetic and/or epigenomic analysis includes determining the epigenetic properties of a cell, e.g., an engineered cell for cell therapy.

Abstract: A circuit breaker for an electric load includes first and second terminals; a number of first separable contacts each electrically connected between one of the first terminals and one of the second terminals; a first mechanism to open, close or trip open the first contacts; a number of second separable contacts each electrically connected in series with a corresponding one of the first contacts; a second mechanism to open or close the second contacts; a processor to cause the second mechanism to open or close the second contacts, annunciate through one of the second terminals a power circuit electrical parameter for the electric load, receive from a number of the second terminals a confirmation from or on behalf of the electric load to cause the second mechanism to close the second contacts, and determine a fault state operatively associated with current flowing through the second contacts.

Abstract: A circuit breaker for an electric load includes first and second terminals; a number of first separable contacts each electrically connected between one of the first terminals and one of the second terminals; a first mechanism to open, close or trip open the first contacts; a number of second separable contacts each electrically connected in series with a corresponding one of the first contacts; a second mechanism to open or close the second contacts; a processor to cause the second mechanism to open or close the second contacts, annunciate through one of the second terminals a power circuit electrical parameter for the electric load, receive from a number of the second terminals a confirmation from or on behalf of the electric load to cause the second mechanism to close the second contacts, and determine a fault state operatively associated with current flowing through the second contacts.

Abstract: A load management system including a number of sensors structured to sense characteristics of a managed area, a controller including a processor structured to estimate occupancy of the managed area based on outputs of the number of sensors and to implement a load management scheme, a number of circuit breakers, at least one of the number of circuit breakers being electrically connected to a corresponding load circuit and including a metering circuit structured to meter energy provided to the load circuit and a device control unit structured to control one or more load devices electrically connected to the load circuit based on the load management scheme. The processor is structured to implement the load management scheme based on outputs of the sensors and metering information of one or more of the circuit breakers.

Abstract: An electric vehicle charging device includes a processing unit having a memory with a routine stored therein which, when executed by the processing unit causes the processing unit to control circuitry to prevent the electric vehicle charging device from charging an electric vehicle for a random delay period and to allow the electric vehicle charging device to charge the electric vehicle starting when the random delay period ends, wherein the random delay period starts at a predetermined start time and lasts a random delay length of time. The random delay reduces the peak load on a transformer that the electric vehicle charging device and other electric vehicle charging devices receive power from.

Abstract: A load management system including a number of sensors structured to sense characteristics of a managed area, a controller including a processor structured to estimate occupancy of the managed area based on outputs of the number of sensors and to implement a load management scheme, a number of circuit breakers, at least one of the number of circuit breakers being electrically connected to a corresponding load circuit and including a metering circuit structured to meter energy provided to the load circuit and a device control unit structured to control one or more load devices electrically connected to the load circuit based on the load management scheme. The processor is structured to implement the load management scheme based on outputs of the sensors and metering information of one or more of the circuit breakers.

Abstract: An electric vehicle charging device includes a processing unit having a memory with a routine stored therein which, when executed by the processing unit causes the processing unit to control circuitry to prevent the electric vehicle charging device from charging an electric vehicle for a random delay period and to allow the electric vehicle charging device to charge the electric vehicle starting when the random delay period ends, wherein the random delay period starts at a predetermined start time and lasts a random delay length of time. The random delay reduces the peak load on a transformer that the electric vehicle charging device and other electric vehicle charging devices receive power from.

Abstract: A load management system including a number of sensors structured to sense characteristics of a managed area, a controller including a processor structured to estimate occupancy of the managed area based on outputs of the number of sensors and to implement a load management scheme, a number of circuit breakers, at least one of the number of circuit breakers being electrically connected to a corresponding load circuit and including a metering circuit structured to meter energy provided to the load circuit and a device control unit structured to control one or more load devices electrically connected to the load circuit based on the load management scheme. The processor is structured to implement the load management scheme based on outputs of the sensors and metering information of one or more of the circuit breakers.

Abstract: An electric power distribution system is used with an electric power source. The electric power distribution system includes a first device exchanging first electric power with the electric power source. The first device exchanges the first electric power with a plurality of second devices and meters first electric energy corresponding to the first electric power. The second devices exchange the first electric power with the first device. Each of the second devices exchanges second electric power as at least part of the first electric power with a number of corresponding electric loads and meter second electric energy corresponding to the second electric power. A processor includes a routine that compares the metered first electric energy from the first device with a sum of the metered second electric energy from each of the second devices, and responsively determines proper or improper operation of the electric power distribution system.

Abstract: An electric vehicle charging device includes a processing unit having a memory with a routine stored therein which, when executed by the processing unit causes the processing unit to control circuitry to prevent the electric vehicle charging device from charging an electric vehicle for a random delay period and to allow the electric vehicle charging device to charge the electric vehicle starting when the random delay period ends, wherein the random delay period starts at a predetermined start time and lasts a random delay length of time. The random delay reduces the peak load on a transformer that the electric vehicle charging device and other electric vehicle charging devices receive power from.

Abstract: An electric power distribution system is used with an electric power source. The electric power distribution system includes a first device exchanging first electric power with the electric power source. The first device exchanges the first electric power with a plurality of second devices and meters first electric energy corresponding to the first electric power. The second devices exchange the first electric power with the first device. Each of the second devices exchanges second electric power as at least part of the first electric power with a number of corresponding electric loads and meter second electric energy corresponding to the second electric power. A processor includes a routine that compares the metered first electric energy from the first device with a sum of the metered second electric energy from each of the second devices, and responsively determines proper or improper operation of the electric power distribution system.

Abstract: An electric vehicle charging device includes a processing unit having a memory with a routine stored therein which, when executed by the processing unit causes the processing unit to control circuitry to prevent the electric vehicle charging device from charging an electric vehicle for a random delay period and to allow the electric vehicle charging device to charge the electric vehicle starting when the random delay period ends, wherein the random delay period starts at a predetermined start time and lasts a random delay length of time. The random delay reduces the peak load on a transformer that the electric vehicle charging device and other electric vehicle charging devices receive power from.

Abstract: An electric vehicle charging device includes a processing unit having a memory with a routine stored therein which, when executed by the processing unit causes the processing unit to control circuitry to prevent the electric vehicle charging device from charging an electric vehicle for a random delay period and to allow the electric vehicle charging device to charge the electric vehicle starting when the random delay period ends, wherein the random delay period starts at a predetermined start time and lasts a random delay length of time. The random delay reduces the peak load on a transformer that the electric vehicle charging device and other electric vehicle charging devices receive power from.

Abstract: An electric power distribution system is used with an electric power source. The electric power distribution system includes a first device exchanging first electric power with the electric power source. The first device exchanges the first electric power with a plurality of second devices and meters first electric energy corresponding to the first electric power. The second devices exchange the first electric power with the first device. Each of the second devices exchanges second electric power as at least part of the first electric power with a number of corresponding electric loads and meter second electric energy corresponding to the second electric power. A processor includes a routine that compares the metered first electric energy from the first device with a sum of the metered second electric energy from each of the second devices, and responsively determines proper or improper operation of the electric power distribution system.

Abstract: A load management system including a number of sensors structured to sense characteristics of a managed area, a controller including a processor structured to estimate occupancy of the managed area based on outputs of the number of sensors and to implement a load management scheme, a number of circuit breakers, at least one of the number of circuit breakers being electrically connected to a corresponding load circuit and including a metering circuit structured to meter energy provided to the load circuit and a device control unit structured to control one or more load devices electrically connected to the load circuit based on the load management scheme. The processor is structured to implement the load management scheme based on outputs of the sensors and metering information of one or more of the circuit breakers.

Abstract: A circuit breaker for an electric load includes first and second terminals; a number of first separable contacts each electrically connected between one of the first terminals and one of the second terminals; a first mechanism to open, close or trip open the first contacts; a number of second separable contacts each electrically connected in series with a corresponding one of the first contacts; a second mechanism to open or close the second contacts; a processor to cause the second mechanism to open or close the second contacts, annunciate through one of the second terminals a power circuit electrical parameter for the electric load, receive from a number of the second terminals a confirmation from or on behalf of the electric load to cause the second mechanism to close the second contacts, and determine a fault state operatively associated with current flowing through the second contacts.

Abstract: An electric power distribution system is used with an electric power source. The electric power distribution system includes a first device exchanging first electric power with the electric power source. The first device exchanges the first electric power with a plurality of second devices and meters first electric energy corresponding to the first electric power. The second devices exchange the first electric power with the first device. Each of the second devices exchanges second electric power as at least part of the first electric power with a number of corresponding electric loads and meter second electric energy corresponding to the second electric power. A processor includes a routine that compares the metered first electric energy from the first device with a sum of the metered second electric energy from each of the second devices, and responsively determines proper or improper operation of the electric power distribution system.

Abstract: An electric vehicle charging device includes a processing unit having a memory with a routine stored therein which, when executed by the processing unit causes the processing unit to control circuitry to prevent the electric vehicle charging device from charging an electric vehicle for a random delay period and to allow the electric vehicle charging device to charge the electric vehicle starting when the random delay period ends, wherein the random delay period starts at a predetermined start time and lasts a random delay length of time. The random delay reduces the peak load on a transformer that the electric vehicle charging device and other electric vehicle charging devices receive power from.

Abstract: An anti-malware system dynamically loads and unloads additional malware detection signatures based on a collection of data sources that indicate what signatures are relevant to a host machine in its current environment. A signature selector component determines what relevant signatures should be loaded. The signature selector component uses a variety of data sources either individually, or in combination, to determine relevancy of the available malware detection signatures. The anti-malware system dynamically determines which of the available malware detection signatures and classes of signatures are relevant and should be provided to a machine based on available information. The malware detection signatures are obtained and loaded automatically from one or more sources when a threat becomes relevant. A program or application may be blocked from accessing files until the relevant malware detection signatures have been loaded onto the machine.

Abstract: An anti-malware system dynamically loads and unloads additional malware detection signatures based on a collection of data sources that indicate what signatures are relevant to a host machine in its current environment. A signature selector component determines what relevant signatures should be loaded. The signature selector component uses a variety of data sources either individually, or in combination, to determine relevancy of the available malware detection signatures. The anti-malware system dynamically determines which of the available malware detection signatures and classes of signatures are relevant and should be provided to a machine based on available information. The malware detection signatures are obtained and loaded automatically from one or more sources when a threat becomes relevant. A program or application may be blocked from accessing files until the relevant malware detection signatures have been loaded onto the machine.