Patents by Inventor Ronald L. Wolin

Ronald L. Wolin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hexahydro-pyrrolo-isoquinoline compounds
    Patent number: 8273762
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Grant
    Filed: June 2, 2010
    Date of Patent: September 25, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
    Publication number: 20110218338
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritus.
    Type: Application
    Filed: April 11, 2011
    Publication date: September 8, 2011
    Inventors: Hui Cai, Frank Chavez, James P. Edwards, Anne E. Fitzgerald, Jing Liu, Neelakandha S. Mani, Danielle K. Neff, Michele C. Rizzolio, Brad M. Savall, Deborah M. Smith, Jennifer D. Venable, Jianmei Wei, Ronald L. Wolin
  • 2-Aminopyrimidine modulators of the histamine H4 receptor
    Publication number: 20110160451
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: March 8, 2011
    Publication date: June 30, 2011
    Inventors: Hui CAI, Frank CHAVEZ, James P. EDWARDS, Anne E. FITZGERALD, Jing LIU, Neelakandha S. MANI, Danielle K. NEFF, Michele C. RIZZOLIO, Brad M. SAVALL, Deborah M. SMITH, Jennifer D. VENABLE, Jianmei WEI, Ronald L. WOLIN
  • 2-Aminopyrimidine modulators of the histamine H4 receptor
    Publication number: 20110160452
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: March 8, 2011
    Publication date: June 30, 2011
    Inventors: Hui Cai, Frank Chavez, James P. Edwards, Anne E. Fitzgerald, Jing Liu, Neelakandha S. Mani, Danielle K. Neff, Michele C. Rizzolio, Brad M. Savall, Deborah M. Smith, Jennifer D. Venable, Jianmai Wei, Ronald L. Wolin
  • Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor
    Publication number: 20110092474
    Abstract: Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: June 11, 2009
    Publication date: April 21, 2011
    Inventors: Hui Cai, Frank Chavez, Paul J. Dunford, Andrew J. Greenspan, Steven P. Meduna, Jorge A. Quiroz, Brad M. Savall, Kevin L. Tays, Robin L. Thurmond, Jianmei Wei, Ronald L. Wolin, Xiaohu Zhang
  • Aryl piperidine amides
    Patent number: 7915420
    Abstract: The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic factor; a neurological disorder; or obesity; an obesity-related disorder.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: March 29, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Charles Q. Huang, Timothy W. Lovenberg, Alejandro Santillán, Jr., Liu Y. Tang, Ronald L. Wolin
  • HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS
    Publication number: 20100240648
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 23, 2010
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • Hexahydro-pyrrolo-isoquinoline compounds
    Patent number: 7754882
    Abstract: Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.
    Type: Grant
    Filed: June 16, 2006
    Date of Patent: July 13, 2010
    Assignee: Janssen Pharmaceutica NV
    Inventors: Richard Apodaca, Ann J. Barbier, Nicholas I. Carruthers, Leslie A. Gomez, John M. Keith, Timothy W. Lovenberg, Ronald L. Wolin
  • Cannabinoid receptor ligands
    Patent number: 7718702
    Abstract: There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds and methods of using the compounds for the treatment of various diseases and conditions.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: May 18, 2010
    Assignee: Schering Corporation
    Inventors: Joseph A. Kozlowski, Neng-Yang Shih, Brian J. Lavey, Razia K. Rizvi, Bandarpalle B. Shankar, James M. Spitler, Ling Tong, Ronald L. Wolin, Michael K. Wong
  • Cannabinoid receptor ligands
    Patent number: 7507767
    Abstract: There are disclosed compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds and methods of using the compounds for the treatment of various diseases and conditions.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: March 24, 2009
    Assignee: Schering Corporation
    Inventors: Joseph A. Kozlowski, Neng-Yang Shih, Brian J. Lavey, Razia K. Rizvi, Bandarpalle B. Shankar, James M. Spitler, Ling Tong, Ronald L. Wolin, Michael K. Wong
  • 2-Aminopyrimidine modulators of the histamine H4 receptor
    Publication number: 20080194577
    Abstract: 2-Aminopyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as allergy, asthma, autoimmune diseases, and pruritis.
    Type: Application
    Filed: February 14, 2008
    Publication date: August 14, 2008
    Inventors: Hui Cai, Frank Chavez, James P. Edwards, Anne E. Fitzgerald, Jing Liu, Neelakandha S. Mani, Danielle K. Neff, Michele C. Rizzolio, Brad M. Savall, Deborah M. Smith, Jennifer D. Venable, Jianmei Wei, Ronald L. Wolin
  • Aryl piperidine amides
    Patent number: 7276610
    Abstract: The invention provides novel GlyT2 inhibiting compounds useful in modulating, treating, or preventing: anxiolytic disorders; a condition requiring treatment of injured mammalian nerve tissue; a condition amenable to treatment through administration of a neurotrophic factor; a neurological disorder; or obesity; an obesity-related disorder.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: October 2, 2007
    Assignee: Janssen Pharaceutica, NV
    Inventors: Charles Q. Huang, Timothy W. Lovenberg, Alejandro Santillán, Jr., Liu Y. Tang, Ronald L. Wolin
  • GlyT2 modulators
    Patent number: 7202269
    Abstract: Certain ?-, ?-, and ?-amino acid derivatives are disclosed as selective GlyT2 inhibitors for the treatment of central nervous system (CNS) conditions such as muscle spasticity, tinnitus, epilepsy and neuropathic pain.
    Type: Grant
    Filed: October 28, 2004
    Date of Patent: April 10, 2007
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Tristin K. Barclay, Alejandro Santillán, Jr., Liu Y. Tang, Hariharan Venkatesan, Ronald L. Wolin
  • Phenyl-substituted imidazopyridines
    Patent number: 7199117
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: April 3, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Phenyl-substituted imidazopyridines
    Patent number: 7087757
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: August 8, 2006
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Cannabinoid receptor ligands
    Patent number: 7067539
    Abstract: The invention relates to compounds of the formula a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit anti-inflammatory and immunodulatory activity. Also disclosed are pharmaceutical compositions containing said compounds and methods of using the compounds for the treatment of various diseases and conditions.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: June 27, 2006
    Assignee: Schering Corporation
    Inventors: Joseph A. Kozlowski, Neng-Yang Shih, Brian J. Lavey, Razia K. Rizvi, Bandarpalle B. Shankar, James M. Spitler, Ling Tong, Ronald L. Wolin, Michael K. Wong
  • Phenyl-substituted imidazopyridines
    Patent number: 7041827
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: May 9, 2006
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Phenyl-substituted imidazopyridines
    Patent number: 7041828
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: May 9, 2006
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Phenyl-substituted imidazopyridines
    Patent number: 6908929
    Abstract: The invention features pharmaceutically-active imidazopyridines and derivatives that are substituted with phenyl, methods of making them, and methods of using them.
    Type: Grant
    Filed: March 29, 2001
    Date of Patent: June 21, 2005
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: J. Guy Breitenbucher, Nicholas I. Carruthers, Xiaobing Li, Laura C. McAtee, Chandravadan R. Shah, Ronald L. Wolin
  • Cannabinoid receptor ligands
    Publication number: 20030232859
    Abstract: The invention relates to compounds of the formula 1
    Type: Application
    Filed: August 7, 2002
    Publication date: December 18, 2003
    Applicant: Schering Corporation
    Inventors: Joseph A. Kozlowski, Neng-Yang Shih, Brian J. Lavey, Razia K. Rizvi, Bandarpalle B. Shankar, James M. Spitler, Ling Tong, Ronald L. Wolin, Michael K. Wong