Patents by Inventor Ronald M. Krauss
Ronald M. Krauss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11007162Abstract: The present invention provides methods for increasing LDL particle size.Type: GrantFiled: October 31, 2018Date of Patent: May 18, 2021Assignee: CymaBay Therapeutics, Inc.Inventors: David Karpf, Ronald M. Krauss, Yun-Jung Choi, Xueyan Wang, Francine M. Gregoire
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Publication number: 20190298672Abstract: The present invention provides methods for increasing LDL particle size.Type: ApplicationFiled: October 31, 2018Publication date: October 3, 2019Applicant: CymaBay Therapeutics, Inc.Inventors: David Karpf, Ronald M. Krauss, Yun-Jung Choi, Xueyan Wang, Francine M. Gregoire
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Publication number: 20180143211Abstract: The present disclosure provides an isolated particle comprising very high density, ultra small, lipid depleted apo B containing particles, and may also contain cytokeratin 8. The isolated particle is useful in diagnostic assays, which are also provided.Type: ApplicationFiled: December 26, 2017Publication date: May 24, 2018Inventors: Ronald M. Krauss, Mohmed Elfatih Ashmaig
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Patent number: 9857385Abstract: The present disclosure provides an isolated particle comprising very high density, ultra small, lipid depleted apo B containing particles, and may also contain cytokeratin 8. The isolated particle is useful in diagnostic assays, which are also provided.Type: GrantFiled: April 25, 2016Date of Patent: January 2, 2018Assignee: Children's Hospital & Research Center at OaklandInventors: Ronald M. Krauss, Mohmed Elfatih Ashmaig
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Publication number: 20160324811Abstract: The present invention provides methods for increasing LDL particle size.Type: ApplicationFiled: January 13, 2016Publication date: November 10, 2016Applicant: CymaBay Therapeutics, Inc.Inventors: David Karpf, Ronald M. Krauss, Yun-Jung Choi, Xueyan Wang, Francine M. Gregoire
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Publication number: 20160231340Abstract: The present disclosure provides an isolated particle comprising very high density, ultra small, lipid depleted apo B containing particles, and may also contain cytokeratin 8. The isolated particle is useful in diagnostic assays, which are also provided.Type: ApplicationFiled: April 25, 2016Publication date: August 11, 2016Inventors: Ronald M. Krauss, Mohmed Elfatih Ashmaig
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Patent number: 9322833Abstract: The present disclosure provides an isolated particle comprising very high density, ultra small, lipid depleted apo B containing particles, and may also contain cytokeratin 8. The isolated particle is useful in diagnostic assays, which are also provided.Type: GrantFiled: June 14, 2012Date of Patent: April 26, 2016Assignee: Children's Hospital & Research Center at OaklandInventors: Ronald M. Krauss, Mohmed Elfatih Ashmaig
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Publication number: 20150126473Abstract: The present disclosure provides an isolated particle comprising very high density, ultra small, lipid depleted apo B containing particles, and may also contain cytokeratin 8. The isolated particle is useful in diagnostic assays, which are also provided.Type: ApplicationFiled: June 14, 2012Publication date: May 7, 2015Applicant: Children's Hospital & Research Center at OaklandInventors: Ronald M. Krauss, Mohmed Elfatih Ashmaig
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Patent number: 8137977Abstract: The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.Type: GrantFiled: October 24, 2008Date of Patent: March 20, 2012Assignees: Children's Hospital & Research Center at Oakland, Duke University, Lipomics Technologies, Inc., Mayo Foundation for Medical Education and ResearchInventors: Rima F. Kaddurah-Daouk, Michelle M. Wiest, Steven M. Watkins, Rebecca Ann Baillie, Madhumita Patnaik, K. Ranga Rama Krishnan, Richard M. Weinshilboum, Ronald M. Krauss
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Patent number: 8097462Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.Type: GrantFiled: December 13, 2010Date of Patent: January 17, 2012Assignee: The Regents of the University of CaliforniaInventors: W. Henry Benner, Ronald M Krauss, Patricia J Blanche
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Patent number: 8084209Abstract: The present invention provides methods for assessing a subject's responsiveness to a HMGCR inhibitor therapy, and selection of a HMGCR inhibitor therapy based upon such methods. The invention further provides methods for identifying agents that modulate HMGCR activity, e.g., through modulating HMGCR mRNA splicing, while avoiding elevation of the statin-resistant isoform of HMGCR.Type: GrantFiled: July 21, 2006Date of Patent: December 27, 2011Assignee: Children's Hospital & Research Center OaklandInventors: Marisa Lin Wong Medina, Ronald M. Krauss
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Publication number: 20110089037Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.Type: ApplicationFiled: December 13, 2010Publication date: April 21, 2011Applicant: The Regents of the University of CaliforniaInventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche
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Patent number: 7851224Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.Type: GrantFiled: May 6, 2010Date of Patent: December 14, 2010Assignee: The Regents of the University of CaliforniaInventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche
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Publication number: 20100213061Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.Type: ApplicationFiled: May 6, 2010Publication date: August 26, 2010Applicant: The Regents of the University of CaliforniaInventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche
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Publication number: 20100152295Abstract: The present invention provides methods for increasing LDL particle size.Type: ApplicationFiled: October 15, 2009Publication date: June 17, 2010Applicant: Metabolex Inc.Inventors: David Karpf, Ronald M. Krauss, Yun-Jung Choi, Xueyan Wang, Francine M. Gregoire
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Patent number: 7713744Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.Type: GrantFiled: June 29, 2007Date of Patent: May 11, 2010Assignee: The Regents of the University of CaliforniaInventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche
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Publication number: 20090197242Abstract: The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject following commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen. The invention further provides a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample from a mammalian subject before commencement of the treatment regimen; and correlating the lipid profile in the sample with a positive or negative response to the treatment regimen.Type: ApplicationFiled: October 24, 2008Publication date: August 6, 2009Inventors: Rima F. Kaddurah-Daouk, Michelle M. Wiest, Steven M. Watkins, Rebecca A. Baillie, Madhumita Patnaik, K. Ranga Rama Krishnan, Richard M. Weinshilboum, Ronald M. Krauss
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Publication number: 20080293054Abstract: The present invention provides methods for assessing a subject's responsiveness to a HMGCR inhibitor therapy, and selection of a HMGCR inhibitor therapy based upon such methods. The invention further provides methods for identifying agents that modulate HMGCR activity, e.g., through modulating HMGCR mRNA splicing, while avoiding elevation of the statin-resistant isoform of HMGCR.Type: ApplicationFiled: July 21, 2006Publication date: November 27, 2008Inventors: Marisa Lin Wong Medina, Ronald M. Krauss
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Patent number: 7259018Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.Type: GrantFiled: November 12, 2002Date of Patent: August 21, 2007Assignee: The Regents of the University of CaliforniaInventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche
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Publication number: 20030136680Abstract: A medical diagnostic method and instrumentation system for analyzing noncovalently bonded agglomerated biological particles is described. The method and system comprises: a method of preparation for the biological particles; an electrospray generator; an alpha particle radiation source; a differential mobility analyzer; a particle counter; and data acquisition and analysis means. The medical device is useful for the assessment of human diseases, such as cardiac disease risk and hyperlipidemia, by rapid quantitative analysis of lipoprotein fraction densities. Initially, purification procedures are described to reduce an initial blood sample to an analytical input to the instrument. The measured sizes from the analytical sample are correlated with densities, resulting in a spectrum of lipoprotein densities. The lipoprotein density distribution can then be used to characterize cardiac and other lipid-related health risks.Type: ApplicationFiled: November 12, 2002Publication date: July 24, 2003Applicant: The Regents of the University of CaliforniaInventors: W. Henry Benner, Ronald M. Krauss, Patricia J. Blanche