Patents by Inventor Ronald Scharf
Ronald Scharf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210101020Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.Type: ApplicationFiled: December 15, 2020Publication date: April 8, 2021Inventors: David Muller, John Marshall, Marc D. Friedman, Stephen Blinn, Ronald Scharf, Pavel Kamaev, Radha Pertaub
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Publication number: 20190365564Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.Type: ApplicationFiled: May 17, 2019Publication date: December 5, 2019Inventors: David Muller, John Marshall, Marc D. Friedman, Stephen Blinn, Ronald Scharf, Pavel Kamaev, Radha Pertaub
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Patent number: 10137239Abstract: Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.Type: GrantFiled: April 27, 2015Date of Patent: November 27, 2018Assignee: Avedro, Inc.Inventors: Marc D. Friedman, Pavel Kamaev, David Muller, Radha Pertaub, Ronald Scharf, Evan Sherr, David Usher
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Publication number: 20180235808Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.Type: ApplicationFiled: April 18, 2018Publication date: August 23, 2018Inventors: David Muller, John Marshall, Marc D. Friedman, Stephen Blinn, Ronald Scharf, Pavel Kamaev, Radha Pertaub
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Publication number: 20150265762Abstract: Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.Type: ApplicationFiled: April 27, 2015Publication date: September 24, 2015Inventors: Marc D. Friedman, Pavel Kamaev, David Muller, Radha Pertaub, Ronald Scharf, Evan Sherr, David Usher
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Patent number: 9020580Abstract: Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.Type: GrantFiled: June 4, 2012Date of Patent: April 28, 2015Assignee: Avedro, Inc.Inventors: Marc D. Friedman, Pavel Kamaev, David Muller, Radha Pertaub, Ronald Scharf, Evan Sherr, David Usher
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Patent number: 8882757Abstract: Systems and methods improve operation of an applicator that delivers heat-generating energy to an eye as a part of an eye therapy. For example, reflected power may be measured to determine whether sufficient contact has been established between the applicator and the eye for accurate and precise delivery of energy to the eye. In addition, at least one of forward and reflected power may be measured to monitor the application of coolant pulses that control the generation of heat in the eye when the applicator delivers energy to the eye. Further, the forward and reflected power may be measured to determine an efficiency of energy transfer or an impedance mismatch. Based on the efficiency of energy transfer or the impedance mismatch, an adjustable parameter of a tuning element may be modified.Type: GrantFiled: November 12, 2009Date of Patent: November 11, 2014Assignee: Avedro, Inc.Inventors: David Muller, Radha Pertaub, Steven Meyers, Russ Dresher, Thomas Ryan, Ronald Scharf
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Patent number: 8712536Abstract: An electrical energy applicator in one embodiment extends from a proximal end to a distal end. The energy conducting applicator includes, at the proximal end, a connection to one or more electrical energy sources. The energy conducting applicator directs electrical energy from the one or more electrical energy sources to the distal end. The energy conducting applicator includes an outer conductor and an inner conductor extending to the distal end. The outer conductor and the inner conductor are separated by a gap. The outer conductor includes a plurality of moveable outer segments and the inner conductor includes a plurality of moveable inner segments. The plurality of outer segments and the plurality of inner segments form a total contact surface at the distal end. The total contact surface is positionable at a surface of an eye. The electrical energy is applied to the eye according to the total contact surface.Type: GrantFiled: April 2, 2010Date of Patent: April 29, 2014Assignee: Avedro, Inc.Inventors: David Muller, Thomas Ryan, Ronald Scharf
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Patent number: 8652131Abstract: A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and a coolant delivery system. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery system is in communication with the coolant supply and is operable to deliver a micro-controlled pulse of coolant to the distal end.Type: GrantFiled: May 14, 2012Date of Patent: February 18, 2014Assignee: Avedro, Inc.Inventors: David Muller, Ronald Scharf, Thomas Ryan, Neal Marshall, Radha Pertaub, Artie Wu
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Publication number: 20130131664Abstract: A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and a coolant delivery system. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery system is in communication with the coolant supply and is operable to deliver a micro-controlled pulse of coolant to the distal end.Type: ApplicationFiled: May 14, 2012Publication date: May 23, 2013Applicant: Avedro, Inc.Inventors: David Muller, Ronald Scharf, Thomas Ryan, Neal Marshall, Radha Pertaub, Artie Wu
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Patent number: 8348935Abstract: A system for applying therapy to an eye includes an applicator having a conducting element configured to direct energy from an energy source to an application end of the conducting element, where the application end has at least one eye contact portion. A positioning system positions the at least one eye contact portion in stable engagement with the eye surface. The conducting element is disposed within a housing for the applicator and at least one adjustment system is employed to move the conducting element relative to the housing. The at least one adjustment system enables controlled movement of the conducting element and the at least one eye contact portion against the corneal surface. In particular embodiments, sufficient contact between the applicator and the cornea is determined by causing applanation of the cornea. In other embodiments, at least one measurement device is employed to determine when sufficient contact has been established.Type: GrantFiled: September 11, 2008Date of Patent: January 8, 2013Assignee: Avedro, Inc.Inventors: David Muller, Ronald Scharf, Thomas Ryan, Neal Marshall, Artie Wu
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Publication number: 20120310083Abstract: Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.Type: ApplicationFiled: June 4, 2012Publication date: December 6, 2012Applicant: Avedro, Inc.Inventors: Marc D. Friedman, Pavel Kamaev, David Muller, Radha Pertaub, Ronald Scharf, Evan Sherr, David Usher
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Publication number: 20120215155Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.Type: ApplicationFiled: April 3, 2012Publication date: August 23, 2012Applicant: Avedro Inc.Inventors: David Muller, John Marshall, Marc D. Friedman, Stephen Blinn, Ronald Scharf, Pavel Kamaev, Radha Pertaub
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Patent number: 8202272Abstract: A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and a coolant delivery system. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery system is in communication with the coolant supply and is operable to deliver a micro-controlled pulse of coolant to the distal end.Type: GrantFiled: September 11, 2008Date of Patent: June 19, 2012Assignee: Avedro, Inc.Inventors: David Muller, Ronald Scharf, Thomas Ryan, Neal Marshall, Radha Pertaub, Artie Wu
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Publication number: 20110237999Abstract: Devices and approaches for activating cross-linking within corneal tissue to stabilize and strengthen the corneal tissue following an eye therapy treatment. A feedback system is provided to acquire measurements and pass feedback information to a controller. The feedback system may include an interferometer system, a corneal polarimetry system, or other configurations for monitoring cross-linking activity within the cornea. The controller is adapted to analyze the feedback information and adjust treatment to the eye based on the information. Aspects of the feedback system may also be used to monitor and diagnose features of the eye 1. Methods of activating cross-linking according to information provided by a feedback system in order to improve accuracy and safety of a cross-linking therapy are also provided.Type: ApplicationFiled: March 18, 2011Publication date: September 29, 2011Applicant: Avedro Inc.Inventors: David Muller, John Marshall, Marc D. Friedman, Stephen Blinn, Ronald Scharf, Pavel Kamaev, Radha Pertaub
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Publication number: 20100256705Abstract: An electrical energy applicator in one embodiment extends from a proximal end to a distal end. The energy conducting applicator includes, at the proximal end, a connection to one or more electrical energy sources. The energy conducting applicator directs electrical energy from the one or more electrical energy sources to the distal end. The energy conducting applicator includes an outer conductor and an inner conductor extending to the distal end. The outer conductor and the inner conductor are separated by a gap. The outer conductor includes a plurality of moveable outer segments and the inner conductor includes a plurality of moveable inner segments. The plurality of outer segments and the plurality of inner segments form a total contact surface at the distal end. The total contact surface is positionable at a surface of an eye. The electrical energy is applied to the eye according to the total contact surface.Type: ApplicationFiled: April 2, 2010Publication date: October 7, 2010Applicant: Avedro, Inc.Inventors: David Muller, Thomas Ryan, Ronald Scharf
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Publication number: 20100256626Abstract: Embodiments according to aspects of the present invention provide a single convenient and versatile tool that allows an operator to apply energy to the cornea according to different patterns to suit different treatment cases, without requiring multiple applicators or interchangeable components. An electrical energy applicator in one embodiment extends from a proximal end to a distal end. The energy conducting applicator includes, at the proximal end, a connection to one or more electrical energy sources. The energy conducting applicator directs electrical energy from the one or more electrical energy sources to the distal end. The distal end is positionable at a surface of an eye. The energy conducting applicator includes at least three selectable conductors coupled to the one or more electrical energy sources. The selectable conductors define an outer conductor and an inner conductor being separated by a gap.Type: ApplicationFiled: April 2, 2010Publication date: October 7, 2010Applicant: Avedro, Inc.Inventors: David Muller, Thomas Ryan, Ronald Scharf
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Publication number: 20100185192Abstract: Systems and methods improve operation of an applicator that delivers heat-generating energy to an eye as a part of an eye therapy. For example, reflected power may be measured to determine whether sufficient contact has been established between the applicator and the eye for accurate and precise delivery of energy to the eye. In addition, at least one of forward and reflected power may be measured to monitor the application of coolant pulses that control the generation of heat in the eye when the applicator delivers energy to the eye. Further, the forward and reflected power may be measured to determine an efficiency of energy transfer or an impedance mismatch. Based on the efficiency of energy transfer or the impedance mismatch, an adjustable parameter of a tuning element may be modified.Type: ApplicationFiled: November 12, 2009Publication date: July 22, 2010Applicant: AVEDRO, INC.Inventors: David Muller, Radha Pertaub, Steven Meyers, Russ Dresher, Thomas Ryan, Ronald Scharf
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Publication number: 20090209954Abstract: A system for applying therapy to an eye includes an applicator having a conducting element configured to direct energy from an energy source to an application end of the conducting element, where the application end has at least one eye contact portion. A positioning system positions the at least one eye contact portion in stable engagement with the eye surface. The conducting element is disposed within a housing for the applicator and at least one adjustment system is employed to move the conducting element relative to the housing. The at least one adjustment system enables controlled movement of the conducting element and the at least one eye contact portion against the corneal surface. In particular embodiments, sufficient contact between the applicator and the cornea is determined by causing applanation of the cornea. In other embodiments, at least one measurement device is employed to determine when sufficient contact has been established.Type: ApplicationFiled: September 11, 2008Publication date: August 20, 2009Inventors: David Muller, Ronald Scharf, Thomas Ryan, Neal Marshall, Artie Wu
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Publication number: 20090069798Abstract: A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and a coolant delivery system. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery system is in communication with the coolant supply and is operable to deliver a micro-controlled pulse of coolant to the distal end.Type: ApplicationFiled: September 11, 2008Publication date: March 12, 2009Inventors: David Muller, Ronald Scharf, Thomas Ryan, Neal Marshall, Radha Pertaub, Artie Wu