Patents by Inventor Ronald W. Berninger

Ronald W. Berninger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation and purification of nucleic acids
    Publication number: 20020009799
    Abstract: In one aspect the present invention provides methods for isolating nucleic acid molecules from a cell, the methods comprising (a) contacting a cell with a solution comprising a biopolymer-degrading enzyme, provided that the biopolymer-degrading enzyme is not a nuclease, and (b) contacting the cell with a solution comprising a hydrophobic surfactant to yield a cell suspension comprising cell, biopolymer-degrading enzyme and hydrophobic surfactant, wherein the hydrophobic surfactant has a critical micelle concentration less than 3.0 mM and the concentration of the hydrophobic surfactant in the cell suspension is at least 0.05% (v/v). In another aspect the present invention provides isolated DNA preparations comprising at least 80% supercoiled DNA. In another aspect the present invention provides isolated nucleic acid preparations having an A260/230 ratio of at least 2.0.
    Type: Application
    Filed: December 8, 2000
    Publication date: January 24, 2002
    Inventors: Randal A. Goffe, Andrae D. Goffe, Ronald W. Berninger
  • Aminooxy-containing linker compounds for formation of stably-linked conjugates and methods related thereto
    Patent number: 5880270
    Abstract: Linker compounds for formation of stably-linked conjugates are disclosed. Such linker compounds are aminooxy-containing linker compounds useful in forming conjugates having stable oxime linkages. The stably-linked conjugates have utility in a variety of immunodiagnostic and separation techniques.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: March 9, 1999
    Assignees: CellPro, Incorporated, Emerald Diagnostics, Inc.
    Inventors: Ronald W. Berninger, Mark S. Lodge, Stanley Joseph Tarnowski, Jr., Floyd Warren Colvin, John Michael Brinkley
  • Semicarbazide-containing linker compounds for formation of stably-linked conjugates and methods related thereto
    Patent number: 5856571
    Abstract: Linker compounds for formation of stably-linked conjugates are disclosed. Such linker compounds are semicarbazide-containing linker compounds useful in forming conjugates having stable semicarbazone linkages. The stably-linked conjugates have utility in a variety of immunodiagnostic and separation techniques.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 5, 1999
    Assignee: CellPro, Incorporated
    Inventors: Ronald W. Berninger, Mark S. Lodge, Stanley Joseph Tarnowski, Jr.