Abstract: An improved process for producing an oil-in-water emulsion to deliver a substantially water insoluble active pharmaceutical ingredient includes creating a microemulsion containing such ingredient in the oil phase of the emulsion by mixing an aqueous phase including non-ionic surfactant, polyol, and water, wherein the weight ratio of the surfactant to polyol to water is between 10:20:70 and 1:1:1, to generate a mixture, with an oil phase comprising a substantially water insoluble active pharmaceutical ingredient and a long-chain triglyceride; circulating the said mixture through a homogenizer at a temperature from 20° C. to 60° C. to generate a coarse emulsion; passing the coarse emulsion through a microfluidizer at a pressure of from 70 MPa to 150 MPa at least once to produce an oil-in-water microemulsion; and, optionally, filtering the microemulsion through a 0.2 ?m filter and/or mixing the microemulsion with a polymeric stabilizer.

Abstract: An improved process for producing an oil-in-water emulsion to deliver a substantially water insoluble active pharmaceutical ingredient includes creating a microemulsion containing such ingredient in the oil phase of the emulsion by mixing an aqueous phase including non-ionic surfactant, polyol, and water, wherein the weight ratio of the surfactant to polyol to water is between 10:20:70 and 1:1:1, to generate a mixture, with an oil phase comprising a substantially water insoluble active pharmaceutical ingredient and a long-chain triglyceride; circulating the said mixture through a homogenizer at a temperature from 20° C. to 60° C. to generate a coarse emulsion; passing the coarse emulsion through a microfluidizer at a pressure of from 70 MPa to 150 MPa at least once to produce an oil-in-water microemulsion; and, optionally, filtering the microemulsion through a 0.2 ?m filter and/or mixing the microemulsion with a polymeric stabilizer.

Abstract: A method of disinfecting the food contact surfaces of a food packaging machine comprises introducing to the machine an aqueous solution comprising from about 0.1% to about 1% by weight of hydrogen peroxide and from about 0.01% to about 0.1% by weight of sodium acid pyrophosphate. The food contact surfaces are contacted with the solution at a temperature of at least about 70.degree. C. for a time period of at least about 15 minutes.

Abstract: An apparatus for sterilizing packaging material is provided. The apparatus includes a container or bath for containing a liquid sterilant through which the packaging material is drawn and guided. The container having an entry opening and exit opening, and guide rollers. At least one spray nozzle located at a position above the level of liquid sterilant for spraying the packaging material with recirculated filter liquid sterilant after it has passed through the liquid sterilant bath is provided.

Abstract: A packaging machine for creating from a web of flexible film a bag for housing a product comprising an apparatus for feeding a web of film through the packaging machine, a sealing station for heating the web of film to create seals in the web of film, the sealing station including a pair of jaws located diametric each other, at least one of the jaws having coupled thereto a member for heating the web of film, and the second jaw having coupled thereto a back-up bar, the jaws being coupled to a member for urging the jaws towards each other. The packaging machine includes boots for segregating a sterile area of the packaging machine through which the web of film is fed, from nonsterile areas, the boots including a plurality of flexible, pleated rubber members that segregate nonsterile internal areas of the sealing station from the sterile area.

Abstract: An apparatus for removing liquid and residue from a web of film is provided. The apparatus includes an exhaust tube having an inlet and an outlet, the web of film passing through the exhaust tube from the inlet through the outlet, the exhaust tube being under a negative pressure. Two air knives are located above the outlet of the exhaust tube, one air knife being located on a first side of the film and second air knife being located on a second side of the film, the air knives include a plurality of holes for directing a gas for removing the liquid and residue onto the web of film. The exhaust tube cooperates with the air knives to capture a portion of the removed liquid and residue.