Abstract: The present invention relates to a drug delivery device for expelling a dose of drug from a held cartridge and that defines a distal drug outlet end and an opposite proximal end. The drug delivery device comprises: a distal housing component (110) holding a cartridge (113) comprising a liquid drug and a piston slideable arranged therein in an axial direction, and a proximal housing component (101) housing a dose setting and expelling mechanism comprising a piston rod for exerting a force on the piston of the cartridge (113) in a distal direction for expelling a dose. The distal housing component (110) and the proximal housing component (101) are displaceably arranged in axial direction relative to each other for reducing an axial distance between the piston rod (120) and the piston of the cartridge (113).

Abstract: The invention relates to a pre-filled injection device for apportioning a plurality of set doses of a liquid drug comprising. The housing of the injection device supports a non-replaceable cartridge containing the liquid drug. The cartridge is e.g. secured in a cartridge-holder being a part of the housing. A needle assembly comprising a needle cannula secured in a hub is slidable mounted to slide into contact with the cartridge. The tip of the needle cannula is covered by a telescopically movable shield movable from an extended position to a retracted position. The telescopically movable shield supports a cleaning chamber containing a cleaning solvent for cleaning at least the distal tip of the needle cannula between subsequent injections. The distal end of the housing supports a removable protective cap and the telescopically movable shield is guided relatively to the housing and coupled to the protective cap to follow movement of the protective cap.

Abstract: The present invention relates to a piston washer (109, 209) for use in a drug delivery device for transferring a distally directed axial force from a piston rod (107, 207) towards a piston (199, 299) of a held cartridge (189, 289). The piston washer (109, 209) defines a proximal surface portion (109a) adapted for engagement with the distal portion of a piston rod (107, 207) and a distal surface portion (109b) configured to engage and abut a piston (199, 299). An axial distance defining device (19a1, 109b1, 109c, 209c) is positioned between the proximal surface portion (109a) and the distal surface portion (109b), wherein the axial distance defining device (19a1, 109b1, 109c, 209c) is configured to be shifted from a first axial compressible state into a second axial non-compressible state. The invention further relates to a drug delivery device incorporating such piston washer (109, 209).

Abstract: The present invention relates to a method of assembling a drug delivery device which in the assembled state defines a distal housing component (102) that houses a piston equipped cartridge (189), and a proximal housing component (101) that houses a dose setting and expelling mechanism. The method includes the steps of arranging the cartridge (189) in the distal housing component (102), arranging a nut element (140) threadedly engaged with a piston rod (107) in the distal housing component (102), and securing the nut element (140) relative to the distal housing component (102) into a selective one of a series of predetermined relative orientations for obtaining a predetermined axial clearance or abutment between the piston rod (107) and the piston of the cartridge (189). The invention further relates to a drug delivery device assembled according to the method.

Abstract: The invention relates to a pre-filled injection device for apportioning a plurality of set doses of a liquid drug comprising. The housing of the injection device supports a non-replaceable cartridge containing the liquid drug. The cartridge is e.g. secured in a cartridge-holder being a part of the housing. A needle assembly comprising a needle cannula secured in a hub is slidable mounted to slide into contact with the cartridge. The tip of the needle cannula is covered by a telescopically movable shield movable from an extended position to a retracted position. The telescopically movable shield supports a cleaning chamber containing a cleaning solvent for cleaning at least the distal tip of the needle cannula between subsequent injections. The distal end of the housing supports a removable protective cap and the telescopically movable shield is guided relatively to the housing and coupled to the protective cap to follow movement of the protective cap.

Abstract: The present invention relates to an injection device for delivering set doses of a liquid drug to a user. The injection device has a scale drum for displaying the set dose, which scale drum is helically guided in a housing. The scale drum is thus rotational in relation to the housing between a zero position and a set position for displaying the set dose. Further, a needle cannula secured to a hub is mounted in an axially movable manner. The axial movement of the hub is generated by a spring. A blocking mechanism interacting between the scale drum and hub controls the axial movement of the hub such that the needle cannula automatically retracts from the skin of a user in response to the scale drum reaching the zero position.

Abstract: The invention relates to an injection device for self-administration of doses of a liquid drug. The injection device carries a needle cannula (15) which is concealed by a telescopically movable shield (20). Further a stopping means (30) interconnects the shield with the helical rotatable scale sleeve (25) such that the shield can only be operated proximally when the scale sleeve is rotated away from its zero position. Once the scale sleeve returns to its zero position during expelling of the dose, the shield and the stopping means is allowed to slide distally and thus return to the locked position.

Abstract: The invention relates to a torsion spring driven injection device for apportioning individually set doses of a liquid drug. The injection device has a needle cannula (35) for multiple uses and a cleaning chamber (56) for cleaning the tip of the needle cannula between subsequent injections. The cleaning chamber is filled with preservative containing liquid drug directly from the cartridge (30) in a filling sequence which is executed when the user initiates first use of the injection device. The sequence comprises the step of securing the piston rod guide in an inrotatable position and thereafter moving the cartridge in a proximal direction. Such axial movement of the cartridge without a similar movement of the plunger automatically pumps liquid drug from the cartridge and into the cleaning chamber via the lumen of the needle cannula.

Abstract: The present invention relates to a piston washer (109, 209) for use in a drug delivery device for transferring a distally directed axial force from a piston rod (107, 207) towards a piston (199, 299) of a held cartridge (189, 289). The piston washer (109, 209) defines a proximal surface portion (109a) adapted for engagement with the distal portion of a piston rod (107, 207) and a distal surface portion (109b) configured to engage and abut a piston (199, 299). An axial distance defining device (19a1, 109b1, 109c, 209c) is positioned between the proximal surface portion (109a) and the distal surface portion (109b), wherein the axial distance defining device (19a1, 109b1, 109c, 209c) is configured to be shifted from a first axial compressible state into a second axial non-com pressible state. The invention further relates to a drug delivery device incorporating such piston washer (109, 209).

Abstract: The present invention relates to a drug delivery device for expelling a dose of drug from a held cartridge and that defines a distal drug outlet end and an opposite proximal end. The drug delivery device comprises: a distal housing component (110) holding a cartridge (113) comprising a liquid drug and a piston slideable arranged therein in an axial direction, and a proximal housing component (101) housing a dose setting and expelling mechanism comprising a piston rod for exerting a force on the piston of the cartridge (113) in a distal direction for expelling a dose. The distal housing component (110) and the proximal housing component (101) are displaceably arranged in axial direction relative to each other for reducing an axial distance between the piston rod (120) and the piston of the cartridge (113).

Abstract: The present invention relates to a method of assembling a drug delivery device which in the assembled state defines a distal housing component (102) that houses a piston equipped cartridge (189), and a proximal housing component (101) that houses a dose setting and expelling mechanism. The method includes the steps of arranging the cartridge (189) in the distal housing component (102), arranging a nut element (140) threadedly engaged with a piston rod (107) in the distal housing component (102), and securing the nut element (140) relative to the distal housing component (102) into a selective one of a series of predetermined relative orientations for obtaining a predetermined axial clearance or abutment between the piston rod (107) and the piston of the cartridge (189). The invention further relates to a drug delivery device assembled according to the method.

Abstract: The invention relates to a pre-filled injection device for apportioning a plurality of set doses of a liquid drug comprising. The housing of the injection device supports a non-replaceable cartridge containing the liquid drug. The cartridge is e.g. secured in a cartridge-holder being a part of the housing. A needle assembly comprising a needle cannula secured in a hub is slidable mounted to slide into contact with the cartridge. The tip of the needle cannula is covered by a telescopically movable shield movable from an extended position to a retracted position. The telescopically movable shield supports a cleaning chamber containing a cleaning solvent for cleaning at least the distal tip of the needle cannula between subsequent injections. The distal end of the housing supports a removable protective cap and the telescopically movable shield is guided relatively to the housing and coupled to the protective cap to follow movement of the protective cap.

Abstract: The invention relates to an injection device for self-administration of doses of a liquid drug. The injection device carries a needle cannula (15) which is concealed by a telescopically movable shield (20). Further a stopping means (30) interconnects the shield with the helical rotatable scale sleeve (25) such that the shield can only be operated proximally when the scale sleeve is rotated away from its zero position. Once the scale sleeve returns to its zero position during expelling of the dose, the shield and the stopping means is allowed to slide distally and thus return to the locked position.

Abstract: The present invention relates to an injection device for delivering set doses of a liquid drug to a user. The injection device has a scale drum for displaying the set dose, which scale drum is helically guided in a housing. The scale drum is thus rotational in relation to the housing between a zero position and a set position for displaying the set dose. Further, a needle cannula secured to a hub is mounted in an axially movable manner. The axial movement of the hub is generated by a spring. A blocking mechanism interacting between the scale drum and hub controls the axial movement of the hub such that the needle cannula automatically retracts from the skin of a user in response to the scale drum reaching the zero position.

Abstract: Aspects of the invention relate to an apparatus including a housing and a slot disposed in the housing, the slot configured to hold an input device in a plurality of upright configurations including at least a forward-facing upright configuration such that the input device faces the front portion of the housing, and at least a backward-facing upright configuration such that the input device faces the back portion of the housing. The slot can be overmolded with a rubber compound (e.g. silicon-based) and configured to provide an improved coefficient of friction to reduce slippage of the input device when held in the slot. In some aspects, the housing includes a surface, and the overmolded portion of the slot can protrude above the surface of the housing.

Abstract: Certain embodiments relate to a protective cover with a housing and a latch mechanism. The latch can be hingeably coupled to a back portion of the housing such that the latch is configured to rotate, via the hinge coupling, from a closed position to an open position. The latch can further be slideably coupled to the housing such that the latch is configured to laterally slide out from the back portion of the housing to an extended position, where the bottom side of the latch can be configured to couple to and secure an input device to the surface of the housing.

Abstract: In certain embodiments, a protective cover includes a housing having a surface, and a latch mechanism hingeably coupled to the housing. The latch can include a top side and a bottom side, the bottom side configured to couple to and secure an input device to the surface of the housing. The latch can be configured to rotate, via the hinge coupling, between a first configuration and second configuration. In the first configuration, the top side of the latch can be flush with the surface of the housing and the bottom side embedded within the housing such that the latch does not protrude from the housing. In the second configuration, the latch can be rotated relative to the first configuration and protrude from the housing. The latch can be operable to be rotated open from the first configuration to the second configuration via the hinge coupling.

Abstract: Certain embodiments relate to a protective cover with a housing and a latch mechanism. The latch can be hingeably coupled to a back portion of the housing such that the latch is configured to rotate, via the hinge coupling, from a closed position to an open position. The latch can further be slideably coupled to the housing such that the latch is configured to laterally slide out from the back portion of the housing to an extended position, where the bottom side of the latch can be configured to couple to and secure an input device to the surface of the housing.

Abstract: Aspects of the invention relate to an apparatus including a housing and a slot disposed in the housing, the slot configured to hold an input device in a plurality of upright configurations including at least a forward-facing upright configuration such that the input device faces the front portion of the housing, and at least a backward-facing upright configuration such that the input device faces the back portion of the housing. The slot can be overmolded with a rubber compound (e.g. silicon-based) and configured to provide an improved coefficient of friction to reduce slippage of the input device when held in the slot. In some aspects, the housing includes a surface, and the overmolded portion of the slot can protrude above the surface of the housing.

Abstract: In certain embodiments, a protective cover includes a housing having a surface, and a latch mechanism hingeably coupled to the housing. The latch can include a top side and a bottom side, the bottom side configured to couple to and secure an input device to the surface of the housing. The latch can be configured to rotate, via the hinge coupling, between a first configuration and second configuration. In the first configuration, the top side of the latch can be flush with the surface of the housing and the bottom side embedded within the housing such that the latch does not protrude from the housing. In the second configuration, the latch can be rotated relative to the first configuration and protrude from the housing. The latch can be operable to be rotated open from the first configuration to the second configuration via the hinge coupling.