Patents by Inventor Rong Hai

Rong Hai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HERPES SIMPLEX VIRUS TYPE 1 DERIVED INFLUENZA VACCINE
    Publication number: 20240050551
    Abstract: In Provided are embodiments of a recombinant nucleic acid comprising a nucleotide sequence encoding a live-attenuated kin chimeric Herpes Simplex Vims Type-1 (HSV-1) VC2 virus and a nucleotide sequence encoding a heterologous polypeptide operably linked to a promoter, wherein the heterologous polypeptide can replace the glycoprotein C (gC) openreading frame (ORF) in VC2, and wherein the nucleotide sequence encoding the heterologous polypeptide can encode the influenza virus hemagglutinin A or a fragment thereof. The constructs may be incorporated in a vaccine effective in generating antibodies against influenza hemagglutinin.
    Type: Application
    Filed: January 12, 2022
    Publication date: February 15, 2024
    Inventors: Paul Jay Fannin RIDER, Rong HAI, Konstantin KOUSOULAS
  • INFLUENZA VIRUS VACCINES AND USES THEREOF
    Publication number: 20190106461
    Abstract: Provided herein are flu hemagglutinin polypeptides, including chimeric influenza virus hemagglutinin polypeptides, and flu hemagglutinin polypeptides comprising modified glycosylation sites and non-naturally glycosylation sites, compositions comprising the same, vaccines comprising the same and methods of their use.
    Type: Application
    Filed: September 24, 2018
    Publication date: April 11, 2019
    Applicant: Icahn School of Medicine at Mount Sinai
    Inventors: Adolfo Garcia-Sastre, Peter Palese, Florian Krammer, Natalie Pica, Dirk Eggink, Rafael A. Medina-Silva, Rong Hai
  • Influenza virus vaccines and uses thereof
    Patent number: 10131695
    Abstract: Provided herein are flu hemagglutinin polypeptides, including chimeric influenza virus hemagglutinin polypeptides, and flu hemagglutinin polypeptides comprising modified glycosylation sites and non-naturally glycosylation sites, compositions comprising the same, vaccines comprising the same and methods of their use.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: November 20, 2018
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: Adolfo Garcia-Sastre, Peter Palese, Florian Krammer, Natalie Pica, Dirk Eggink, Rafael A. Medina-Silva, Rong Hai
  • INFLUENZA VIRUS VACCINES AND USES THEREOF
    Publication number: 20150132330
    Abstract: Provided herein are flu hemagglutinin polypeptides, including chimeric influenza virus hemagglutinin polypeptides, and flu hemagglutinin polypeptides comprising modified glycosylation sites and non-naturally glycosylation sites, compositions comprising the same, vaccines comprising the same and methods of their use.
    Type: Application
    Filed: September 19, 2012
    Publication date: May 14, 2015
    Inventors: Adolfo Garcia-Sastre, Peter Palese, Florian Krammer, Natalie Pica, Dirk Eggink, Rafael A. Medina-Silva, Rong Hai