Patents by Inventor Rosana Kapeller-Libermann

Rosana Kapeller-Libermann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR TREATING DISEASE
    Publication number: 20230374058
    Abstract: The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein.
    Type: Application
    Filed: July 26, 2023
    Publication date: November 23, 2023
    Inventors: Donna L. ROMERO, Oliver Saunders, Gregory Stuart Bisacchi, Dennis Zaller, Rosana Kapeller-Libermann
  • COMPOUNDS AND METHODS FOR TREATING DISEASE
    Publication number: 20230295212
    Abstract: The invention provides compounds, compositions and methods for treating medical disorders, such as cancer, an autoimmune disorder, and/or a neurological disorder, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a compound according to Formula I or a pharmaceutically acceptable salt thereof, or a related compound provided herein.
    Type: Application
    Filed: April 7, 2023
    Publication date: September 21, 2023
    Inventors: Donna L. ROMERO, Oliver SAUNDERS, Gregory Stuart BISACCHI, Dennis ZALLER, Rosana KAPELLER-LIBERMANN
  • ACC INHIBITOR COMBINATION THERAPY FOR THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
    Publication number: 20190381045
    Abstract: The present invention provides methods of treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease using an ACC inhibitor alone or with one or more additional therapeutic agents.
    Type: Application
    Filed: May 13, 2019
    Publication date: December 19, 2019
    Inventors: Geraldine C. Harriman, H. James Harwood, Rosana Kapeller-Libermann, William F. Westlin
  • Peptidomimetic macrocycles
    Patent number: 10300109
    Abstract: Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an ?,?-disubstituted amino acid, or may comprise a crosslinker linking the ?-positions of at least two amino acids or at least one of said two amino acids may be an ?,?-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: May 28, 2019
    Assignee: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jia-Wen Han, Tomi K. Sawyer, Justin Noehre, Noriyuki Kawahata
  • THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20190071469
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: June 29, 2018
    Publication date: March 7, 2019
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20180085426
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 21, 2017
    Publication date: March 29, 2018
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Jia-Wen HAN, Tomi K. SAWYER, Justin NOEHRE, Noriyuki KAWAHATA
  • ACC INHIBITOR COMBINATION THERAPY FOR THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE
    Publication number: 20180021341
    Abstract: The present invention provides methods of treating, stabilizing or lessening the severity or progression of a non-alcoholic fatty liver disease using an ACC inhibitor alone or with one or more additional therapeutic agents.
    Type: Application
    Filed: January 8, 2016
    Publication date: January 25, 2018
    Inventors: Geraldine C. Harriman, H. James Harwood, Rosana Kapeller-Libermann, William F. Westlin
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170298099
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 19, 2017
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170299576
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 6, 2016
    Publication date: October 19, 2017
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20170266254
    Abstract: Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an ?,?-disubstituted amino acid, or may comprise a crosslinker linking the ?-positions of at least two amino acids or at least one of said two amino acids may be an ?,?-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
    Type: Application
    Filed: November 11, 2016
    Publication date: September 21, 2017
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Jia-Wen HAN, Tomi K. SAWYER, Justin NOEHRE, Noriyuki KAWAHATA
  • IRAK inhibitors and uses thereof
    Patent number: 9751892
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: September 5, 2017
    Assignee: Nimbus Iris, Inc.
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
    Publication number: 20170212125
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: August 10, 2016
    Publication date: July 27, 2017
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • Peptidomimetic macrocycles with improved properties
    Patent number: 9458202
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: October 4, 2016
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160193216
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 20, 2015
    Publication date: July 7, 2016
    Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Shaughnessy Robinson, Mee Shelley, Matthew David Wessel, Jeremy Robert Greenwood, Craig E. Masse, Rosana Kapeller-Libermann
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160108089
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: May 21, 2015
    Publication date: April 21, 2016
    Inventors: Huw W. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20160096873
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: September 25, 2015
    Publication date: April 7, 2016
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20160068543
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 17, 2015
    Publication date: March 10, 2016
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • IRAK inhibitors and uses thereof
    Patent number: 9212190
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: December 15, 2015
    Assignee: Nimbus Iris, Inc.
    Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Shaughnessy Robinson, Mee Shelley, Matthew David Wessel, Jeremy Robert Greenwood, Craig E. Masse, Rosana Kapeller-Libermann
  • IRAK inhibitors and uses thereof
    Patent number: 9175007
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: November 3, 2015
    Assignee: Nimbus Iris, Inc.
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20150038430
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: July 8, 2014
    Publication date: February 5, 2015
    Inventors: Huw M NASH, David Allen ANNIS, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Jiawen HAN