Patents by Inventor Rosana Kapeller

Rosana Kapeller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic peptidomimetic macrocycles
    Patent number: 8808694
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: August 19, 2014
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20140194417
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 10, 2014
    Applicant: Nimbus Iris, Inc.
    Inventors: Jeremy Robert Greenwood, Geraldine C. Harriman, Rosana Kapeller-Libermann, Craig E. Masse, Shaughnessy Robinson, Donna L. Romero, Mee Shelley, Ronald T. Wester
  • IRAK INHIBITORS AND USES THEREOF
    Publication number: 20130231328
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: January 10, 2013
    Publication date: September 5, 2013
    Applicant: NIMBUS IRIS, INC.
    Inventors: Geraldine C. Harriman, Ronald T. Wester, Donna L. Romero, Shaughnessy Robinson, Mee Shelley, Matthew David Wessel, Jeremy Robert Greenwood, Craig E. Masse, Rosana Kapeller-Libermann
  • Peptidomimetic macrocycles
    Patent number: 8524653
    Abstract: Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins, and methods of identifying and making such improved polypeptides are described.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: September 3, 2013
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Llbermann, Tomi K. Sawyer, Noriyuki Kawahata
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130072439
    Abstract: Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
    Type: Application
    Filed: September 22, 2010
    Publication date: March 21, 2013
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jia-wen Han, Tomi K. Sawyer, Justin Noehre, Noriyuki Kawahata
  • Peptidomimetic macrocycles
    Patent number: 8399405
    Abstract: Biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides; and methods of making and identifying such improved polypeptides.
    Type: Grant
    Filed: February 3, 2012
    Date of Patent: March 19, 2013
    Assignee: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20130023646
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: August 8, 2012
    Publication date: January 24, 2013
    Applicant: AILERON THERAPEUTICS, INC.
    Inventors: Huw M. NASH, Rosana KAPELLER-LIBERMANN, Tomi K. SAWYER, Noriyuki KAWAHATA, Vincent GUERLAVAIS, Matthew IADANZA
  • Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor
    Patent number: 8334111
    Abstract: The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: December 18, 2012
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruth E. Gimeno, Rosana Kapeller-Libermann, Zhidan Wu, Brian K. Hubbard
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120178700
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: July 12, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR
    Publication number: 20120177661
    Abstract: The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
    Type: Application
    Filed: March 20, 2012
    Publication date: July 12, 2012
    Inventors: Ruth E. Gimeno, Zhidan Wu, Rosana Kapeller-Libermann, Brian K. Hubbard
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120172311
    Abstract: The present invention provides biologically active crosslinked polypeptides with improved properties relative to their corresponding precursor polypeptides, having good cell penetration properties and reduced binding to human proteins. The invention additionally provides methods of identifying and making such improved polypeptides.
    Type: Application
    Filed: February 3, 2012
    Publication date: July 5, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata
  • THERAPEUTIC PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120149648
    Abstract: The present invention provides biologically active peptidomimetic macrocycles for the treatment of cell proliferative disorders such as cancer and immunoproliferative disease.
    Type: Application
    Filed: January 17, 2012
    Publication date: June 14, 2012
    Applicant: Aileron Therapeutics, Inc.
    Inventors: Huw M. Nash, David Allen Annis, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Jiawen Han
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120115783
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: May 10, 2012
    Applicant: Alleron therapeutics, Inc
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120115793
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: May 10, 2012
    Applicant: Alleron Therapeutics, Inc
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • PEPTIDOMIMETIC MACROCYCLES
    Publication number: 20120101047
    Abstract: The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
    Type: Application
    Filed: September 22, 2009
    Publication date: April 26, 2012
    Applicant: Aileron Therapetics Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Jiawen Han, Tomi K. Sawyer, Justin Noehre
  • HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR
    Publication number: 20120003233
    Abstract: The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
    Type: Application
    Filed: January 28, 2011
    Publication date: January 5, 2012
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Ruth E. Gimeno, Zhidan Wu, Rosana Kapeller-Libermann, Brian K. Hubbard
  • NOVEL HUMAN TRANSFERASE FAMILY MEMBERS AND USES THEREOF
    Publication number: 20110182879
    Abstract: The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 46743, 27417, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 46743, 27417, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 46743, 27417, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 46743, 27417, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 46743, 27417, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Application
    Filed: July 1, 2010
    Publication date: July 28, 2011
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Rachel E. Meyers, Mark Williamson, Kevin R. Leiby, Rosana Kapeller-Libermann, Peter J. Olandt, Kyle J. MacBeth, Laura A. Rudolph-Owen, Fong-Ying Tsai, John J. Hunter
  • 17867, a novel human aminopeptidase
    Patent number: 7977059
    Abstract: The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the aminopeptidase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the aminopeptidase polypeptides and polynucleotides. The invention further relates to procedures for producing the aminopeptidase polypeptides and polynucleotides.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: July 12, 2011
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Rosana Kapeller-Libermann, Mark Williamson
  • Biologically Active Peptidomimetic Macrocycles
    Publication number: 20110144303
    Abstract: The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
    Type: Application
    Filed: October 13, 2009
    Publication date: June 16, 2011
    Applicant: AILERON Therapeutics, Inc.
    Inventors: Huw M. Nash, Rosana Kapeller-Libermann, Tomi K. Sawyer, Noriyuki Kawahata, Vincent Guerlavais, Matthew Iadanza
  • Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor
    Patent number: 7910346
    Abstract: The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: March 22, 2011
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Ruth E. Gimeno, Rosana Kapeller-Libermann, Zhidan Wu, Brian K. Hubbard