Abstract: Disclosed herein are methods, platform, antibodies, vaccines, constructs, and kits for generating a modified multispanning membrane polypeptide. In some instances, also disclosed herein are methods, platform, antibodies, vaccines, constructs, and kits for generating a modified ion channel polypeptide. In some cases, further disclosed herein are methods, platform, antibodies, vaccines, constructs, and kits for generating a modified GPCR.

Abstract: Disclosed herein are methods, platform, antibodies, vaccines, constructs, and kits for generating a modified multispanning membrane polypeptide. In some instances, also disclosed herein are methods, platform, antibodies, vaccines, constructs, and kits for generating a modified ion channel polypeptide. In some cases, further disclosed herein are methods, platform, antibodies, vaccines, constructs, and kits for generating a modified GPCR.

Abstract: A portable apparatus to sample and analyze volatile organic compounds in breath air, includes: a box internally divided in two internal sections, each housing a sample collecting tube or filter in turn containing a stationary phase suitable for retaining determined analytes, as drugs and/or respective metabolites, having specific chemical physical properties, contained in breath air; a pre-accumulation chamber for receiving breath air from the outside through a breath entrance connection and for feeding the received breath air to the sample collecting filters housed in the two sections, with these two sample collecting filters being connected in parallel to the chamber; and a tool application kit for removing the two sample collecting filters from the respective sections in the box of the apparatus, in a way that avoids any contamination thereof, and for extracting the analytes that are retained by the stationary phase on the same two sample collecting filters.

Abstract: A portable apparatus to sample and analyze volatile organic compounds in breath air, includes: a box internally divided in two internal sections, each housing a sample collecting tube or filter in turn containing a stationary phase suitable for retaining determined analytes, as drugs and/or respective metabolites, having specific chemical physical properties, contained in breath air; a pre-accumulation chamber for receiving breath air from the outside through a breath entrance connection and for feeding the received breath air to the sample collecting filters housed in the two sections, with these two sample collecting filters being connected in parallel to the chamber; and a tool application kit for removing the two sample collecting filters from the respective sections in the box of the apparatus, in a way that avoids any contamination thereof, and for extracting the analytes that are retained by the stationary phase on the same two sample collecting filters.