Patents by Inventor Rosario Lizio
Rosario Lizio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8951558Abstract: The invention relates to an aqueous medium containing an amino(meth)acrylate polymer or copolymer which is not soluble in dematerialised water, characterized in that the medium has a content of an aqueous phase of at least 60% by weight and a content of up to 40% by weight of solids comprising the amino(meth)acrylate polymer or copolymer, whereby the aqueous phase is charged by a sufficient amount of carbon dioxide that effects the amino(meth)acrylate polymer or copolymer to be present in solute form in the medium. The aqueous medium may be used beneficially as a coating or binding solution for the spray coating or binding of pharmaceutical compositions or nutraceutical compositions or cosmetical compositions.Type: GrantFiled: July 30, 2009Date of Patent: February 10, 2015Assignee: Evonik Röhm GmbHInventors: Rosario Lizio, Michael Damm, Hans-Ulrich Petereit
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Patent number: 8765152Abstract: The invention relates to a pharmaceutical or nutraceutical formulation comprising a core, comprising an active pharmaceutical or nutraceutical ingredient, a penetration promoter and a bioavailability promoting agent, and a polymeric coating for the gastrointestinal targeted release of the active ingredient, characterized in that the bioavailability promoting agent is a pharmaceutically acceptable inhibitor of proteolytic enzymes, which increases the oral bioavailability of the active ingredient by a factor of at least five, compared to a corresponding formulation without the bioavailability promoting agent.Type: GrantFiled: February 25, 2010Date of Patent: July 1, 2014Assignee: Evonik Roehm GmbHInventors: Rosario Lizio, Michael Gottschalk, Michael Damm, Norbert Windhab, Melanie Liefke, Guenter Schmitt, Erna Roth, Ruediger Alexowsky
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Patent number: 8734849Abstract: The invention relates to an oral, multiparticle pharmaceutical dosage form containing pellets, the size of which ranges from 50 to 2500 ?m and which essentially consist of: a) an inner matrix layer containing an active substance which is a peptide or a protein, including the derivatives or conjugates thereof, and which is embedded in a matrix consisting of a polymer with mucoadhesive effect, and b) an outer film coating essentially consisting of an anionic polymer or copolymer, which can be optionally formulated with pharmaceutically conventional adjuvants, more particularly softening agents.Type: GrantFiled: July 15, 2004Date of Patent: May 27, 2014Assignee: Evonik Roehm GmbHInventors: Rosario Lízio, Hans-Ulrich Petereit, Erna Roth, Inès Andres, Michael Damm
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Patent number: 8568778Abstract: The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients.Type: GrantFiled: November 5, 2005Date of Patent: October 29, 2013Assignee: Evonik Röhm GmbHInventors: Rosario Lizio, Hans-Ulrich Petereit, Dave Trupti, Michael Gottschalk
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Patent number: 8431157Abstract: The invention relates to a partly neutralized anionic (meth)acrylate copolymer consisting of radically polymerized units containing 25-95% by weight (meth)acrylic acid C1 to C4 alkylesters and 5-75% by weight (meth)acrylate monomer with an anionic group, wherein 0.1 to 25% contained anionic groups are neutralized by a base. Said invention is characterized in that said base is embodied in the form of an cationic organic base whose molecular weight is greater than 150. A medical form containing said partly neutralized anionic (meth)acrylate copolymer and the use of said partly neutralized anionic (meth)acrylate copolymer for producing a medical form rapidly releasing an active substance having a determined pH value are also disclosed.Type: GrantFiled: December 15, 2005Date of Patent: April 30, 2013Assignee: Evonik Roehm GmbHInventors: Rosario Lizio, Hans-Ulrich Petereit, Erna Roth, Michael Damm, Ruediger Alexowsky
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Publication number: 20130058986Abstract: The present invention provides a solid dosage form including an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating; wherein the inner coating includes a partially neutralized anionic polymeric material and at least a carboxylic acid having 2 to 16 carbon atoms, the salts thereof, or mixtures of the acid and its salt; wherein the outer coating includes an anionic polymeric material which is less neutralized than the material of the inner coating or not at all neutralized.Type: ApplicationFiled: September 5, 2012Publication date: March 7, 2013Applicant: EVONIK ROEHM GMBHInventors: Fang LIU, Abdul W. Basit, Rosario Lizio, Hans-Ulrich Petereit, Christian Meier, Michael Damm
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Publication number: 20120315334Abstract: The invention relates to a pharmaceutical or nutraceutical formulation comprising a core, comprising an active pharmaceutical or nutraceutical ingredient, a penetration promoter and a bioavailability promoting agent, and a polymeric coating for the gastrointestinal targeted release of the active ingredient, characterized in that the bioavailability promoting agent is a pharmaceutically acceptable inhibitor of proteolytic enzymes, which increases the oral bioavailability of the active ingredient by a factor of at least five, compared to a corresponding formulation without the bioavailability promoting agent.Type: ApplicationFiled: February 25, 2010Publication date: December 13, 2012Applicant: Evonik Roehm GmbHInventors: Rosario Lizio, Michael Gottschalk, Michael Damm, Norbert Windhab, Melanie Liefke, Guenter Schmitt, Erna Roth, Ruediger Alexowsky
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Patent number: 8273375Abstract: The invention relates to an oral multiparticle pharmaceutical dosage form in the form of a receptacle reducing the pH values of stomach, containing a plurality of pellets, particles, granules or agglomerates whose mean diameter ranges from 50 to 2500 ?n substentially consisting of a) an internal matrix layer containing an active agent which is neither peptide or protein, nor the derivatives or conjugates thereof, a lipophilic matrix whose melting point is greater than 37° C. and a polymer with mucoadhesive effect, b) an external film coating substentially consisting of a polymer or an anionic copolymer which is optionally formulated with conventional pharmaceutical additives, wherein the active agent has a water solubility according to DAB 10, of at least 30 volume parts of water for one part by weight of the active agent and is coated with the lipophilic matrix and said active agent-containing lipophilic matrix is coated with a matrix made of a polymer with mucoadhesive effect.Type: GrantFiled: July 8, 2005Date of Patent: September 25, 2012Assignee: Evonik Roehm GmbHInventors: Rosario Lizio, Hans-Ulrich Petereit, Peter Langguth, Marcus Knöll
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Publication number: 20120143039Abstract: The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.Type: ApplicationFiled: August 30, 2010Publication date: June 7, 2012Applicant: Evonik Roehm GmbHInventors: Benedikt Hartwig, Norbert Windhab, Melanie Liefke, Juan Tome Alcalde, Michael Damm, Rosario Lizio, Michael Gottschalk, Angela Olf, Christian Meier, Andreas Gryczke
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Publication number: 20120087977Abstract: The invention relates to an aqueous medium containing an amino(meth)acrylate polymer or copolymer which is not soluble in demineralised water, characterized in that the medium has a content of an aqueous phase of at least 60% by weight and a content of up to 40% by weight of solids comprising the amino(meth)acrylate polymer or copolymer, whereby the aqueous phase is charged by a sufficient amount of carbon dioxide that effects the amino(meth)acrylate polymer or copolymer to be present in solute form in the medium. The aqueous medium may be used beneficially as a coating or binding solution for the spray coating or binding of pharmaceutical compositions or nutraceutical compositions or cosmetical compositions.Type: ApplicationFiled: July 30, 2009Publication date: April 12, 2012Applicant: Evonik Roehm GmbHInventors: Rosario Lizio, Michael Damm, Hans-Ulrich Petereit
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Patent number: 7871643Abstract: A pharmaceutical form, contains an active compound-containing core, which is covered with a coating layer of a gastric juice-resistant, intestinal juice-soluble (meth)acrylate copolymer, a separating layer situated between said core and said coating layer, the separating layer containing a film-forming water-soluble polymer, wherein the separating layer contains at least two layers: an inner layer containing a water-repellent substance, and thereon a layer comprising the film-forming water-soluble polymer.Type: GrantFiled: July 20, 2007Date of Patent: January 18, 2011Assignee: Evonik Roehm GmbHInventors: Rosario Lizio, Erna Roth, Hans-Ulrich Petereit
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Publication number: 20100129446Abstract: The present invention refers to a solid dosage form comprising an inner coating located between a core containing a pharmaceutically active ingredient and an outer enteric coating; wherein said inner coating comprises a partially neutralized anionic polymeric material, and at least a carboxylic acid having 2 to 16 carbon atoms the salts thereof or mixtures of said acid and its salt; wherein said outer coating comprises an anionic polymeric material which is less or not at all neutralized than the material of the inner coating.Type: ApplicationFiled: May 7, 2007Publication date: May 27, 2010Applicant: Evonik Roehm GmbHInventors: Fang Liu, Abdul W. Basit, Rosario Lizio, Hans-Ulrich Petereit, Christian Meier, Michael Damm
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Publication number: 20090280183Abstract: The invention relates to an oral, multiparticulate form of administration, comprising pellets in the size ranging from 50 to 2500 $g(m)m which are substantially constituted of a) an inner matrix layer containing nanoparticles that contain a nucleic acid active ingredient and being embedded in a matrix of a polymer having a mucoadhesive effect, and b) an outer film coating, substantially consisting of an anionic polymer or copolymer that is optionally formulated with pharmaceutically conventional adjuvants, especially emollients.Type: ApplicationFiled: November 5, 2005Publication date: November 12, 2009Inventors: Rosario Lizio, Hans-Ulrich Petereit, Dave Trupti, Michael Gottschalk
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Publication number: 20090142407Abstract: The invention relates to solid pharmaceutical preparations, in particular for inhalatory administration in mammals, their preparation and their use such as, for example, in powder inhalers.Type: ApplicationFiled: June 4, 2008Publication date: June 4, 2009Applicant: MEDA Pharama GmbH & Co. KGInventors: Rosario Lizio, Michael Damm, Werner Sarlikiotis, Elisabeth Wolf-Heuss
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Publication number: 20090041842Abstract: The invention relates to a partly neutralised anionic (meth)acrylate copolymer consisting of radically polymerised units containing 25-95% by weight (meth)acrylic acid C1 to C4 alkylesters and 5-75% by weight (meth)acrylate monomer with an anionic group, wherein 0.1 to 25% contained anionic groups are neutralised by a base. Said invention is characterised in that said base is embodied in the form of an cationic organic base whose molecular weight is greater than 150. A medical form containing said partly neutralised anionic (meth)acrylate copolymer and the use of said partly neutralised anionic (meth)acrylate copolymer for producing a medical form rapidly releasing an active substance having a determined pH value are also disclosed.Type: ApplicationFiled: December 15, 2005Publication date: February 12, 2009Applicant: Roehm GmbHInventors: Rosario Lizio, Hans-Ulrich Petereit, Erna Roth, Michael Damm, Ruediger Alexowsky
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Publication number: 20080220080Abstract: The invention relates to a multiparticulate pharmaceutical form, comprising pellets with a multilayer structure for controlled active ingredient release, comprising a) a core layer comprising a substance having a modulating effect, b) an inner controlling layer which influences the delivery of the substance having a modulating effect, consisting of pharmaceutically usable polymers, waxes, resins and/or proteins, c) an active ingredient layer comprising an active pharmaceutical ingredient and, where appropriate, a substance having a modulating effect, d) an outer controlling layer comprising at least 60% by weight of one or a mixture of a plurality of (meth)acrylate copolymers where the layers may additionally and in a manner known per se comprise pharmaceutically usual excipients, where the outer controlling layer d) has a thickness from 20 to less than 55 ?m and contains 0.Type: ApplicationFiled: March 3, 2006Publication date: September 11, 2008Applicant: RÖHM GMBHInventors: Hans-Ulrich Petereit, Rosario Lizio, Hema Ravishankar, Ashwini Samel
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Publication number: 20080166416Abstract: The invention relates to an oral multiparticle pharmaceutical dosage form in the form of a receptacle reducing the pH values of stomach, containing a plurality of pellets, particles, granules or agglomerates whose mean diameter ranges from 50 to 2500 ?n substentially consisting of a) an internal matrix layer containing an active agent which is neither peptide or protein, nor the derivatives or conjugates thereof, a lipophilic matrix whose melting point is greater than 37° C. and a polymer with mucoadhesive effect, b) an external film coating substentially consisting of a polymer or an anionic copolymer which is optionally formulated with conventional pharmaceutical additives, wherein the active agent has a water solubility according to DAB 10, of at least 30 volume parts of water for one part by weight of the active agent and is coated with the lipophilic matrix and said active agent-containing lipophilic matrix is coated with a matrix made of a polymer with mucoadhesive effect.Type: ApplicationFiled: July 8, 2005Publication date: July 10, 2008Applicant: Roehm GMBHInventors: Rosario Lizio, Hans-Ulrich Petereit, Peter Langguth, Marcus Knoll
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Publication number: 20080152719Abstract: The invention relates to a multiparticulate pharmaceutical form, comprising pellets with a multilayer structure for controlled active ingredient release, comprising a) optionally a neutral core (nonpareilles), b) an inner controlling layer comprising a substance having a modulating effect, which is embedded in a matrix which influences the delivery of the modulatory substance and which comprises pharmaceutically usable polymers, waxes, resins and/or proteins, and where appropriate an active ingredient, c) an active ingredient layer comprising an active pharmaceutical ingredient and, where appropriate, a substance having a modulating effect, d) an outer controlling layer comprising at least 60% by weight of one or a mixture of a plurality of (meth) acrylate copolymers where the outer controlling layer has a thickness from 20 to less than 55 ?m and contains 0,1 to 10% by weight of glycerol monostearate, where the multiparticulate pharmaceutical form contains 20 to 60% by weight of the pellets, which are compresType: ApplicationFiled: March 3, 2006Publication date: June 26, 2008Applicant: ROEHM GMBHInventors: Hans-Ulrich Petereit, Rosario Lizio, Hema Ravishankar, Ashwini Samel
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Publication number: 20080026051Abstract: A pharmaceutical form, contains an active compound-containing core, which is covered with a coating layer of a gastric juice-resistant, intestinal juice-soluble (meth)acrylate copolymer, a separating layer situated between said core and said coating layer, the separating layer containing a film-forming water-soluble polymer, wherein the separating layer contains at least two layers: an inner layer containing a water-repellent substance, and thereon a layer comprising the film-forming water-soluble polymer.Type: ApplicationFiled: July 20, 2007Publication date: January 31, 2008Applicant: ROEHM GMBHInventors: Rosario LIZIO, Erna ROTH, Hans-Ulrich PETEREIT
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Publication number: 20070042045Abstract: The invention relates to a multilayer pharmaceutical form for controlled active ingredient release, essentially comprising a) optionally a neutral core (nonpareilles), b) an inner controlling layer comprising a substance having a modulating effect, which is embedded in a matrix which influences the delivery of the modulatory substance and which comprises pharmaceutically usable polymers, waxes, resins and/or proteins, and where appropriate an active ingredient, c) an active ingredient layer comprising an active pharmaceutical ingredient and, where appropriate, a substance having a modulating effect, d) an outer controlling layer comprising at least 60% by weight of one or a mixture of a plurality of (meth)acrylate copolymers composed of 98 to 85 C1 to C4 alkyl esters of (meth)acrylic acid and 2 to 15% by weight of methacrylate monomers with a quaternary ammonium group in the alkyl radical, and, where appropriate, further water-insoluble pharmaceutically usable polymers, where the layers may additionally andType: ApplicationFiled: September 15, 2004Publication date: February 22, 2007Applicant: ROEHM GBMH & CO. KGInventors: Rosario Lizio, Hans-Ulrich Petereit, Manfred Assmus, Herna Ravishankar