Patents by Inventor Rosemarie Mang

Rosemarie Mang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220218713
    Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed
    Type: Application
    Filed: March 23, 2022
    Publication date: July 14, 2022
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20210113571
    Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed
    Type: Application
    Filed: December 30, 2020
    Publication date: April 22, 2021
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20200281933
    Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed:
    Type: Application
    Filed: May 22, 2020
    Publication date: September 10, 2020
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20200030335
    Abstract: A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2?, and if m=1 then R3 is on position 1?); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl; R2 is hydrogen or —(C3-6)cycloalkyl, or —unsubstituted (C1-6)alkyl, or —(C1-6)alkyl substituted by one or more of —hydroxy; preferably one or two, —methoxy, —halogen, —(C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e.g. selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or —with the proviso that R3 is bound to 2? R3 represents —O—(CH2)P—O— with p is 2 or 3; R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl.
    Type: Application
    Filed: October 4, 2019
    Publication date: January 30, 2020
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20190175603
    Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed:
    Type: Application
    Filed: February 15, 2019
    Publication date: June 13, 2019
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20180303842
    Abstract: Pleuromutilin derivative compounds of the following formula (I), and uses thereof for the treatment of diseases mediated by microbes, are disclosed:
    Type: Application
    Filed: June 29, 2018
    Publication date: October 25, 2018
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20170266194
    Abstract: A compound of formula (I) wherein n is 0 to 4; m is 0 or 1 with the proviso that the sulphur atom and R3 are in vicinal position (if m=0 then R3 is in position 2?, and if m=1 then R3 is on position 1?); R is ethyl or vinyl; R1 is hydrogen or (C1-6)alkyl; R2 is hydrogen or—(C3-6)cycloalkyl, or—unsubstituted (C1-6)alkyl, or—(C1-6)alkyl substituted by one or more of—hydroxy; preferably one or two,—methoxy,—halogen,—(C3-6)cycloalkyl, or R1 and R2 together with the nitrogen atom to which they are attached form a 5 to 7 membered heterocyclic ring containing at least 1 nitrogen atom or 1 nitrogen and 1 additional heteroatome e. g. selected from N or O, or R1 is hydroxy and R2 is formyl; R3 is OH, OR4, a halogen atom, or—with the proviso that R3 is bound to 2? R3 represents —O—(CH2)P—O— with p is 2 or 3; R4 is unsubstituted (C1-6)alkyl or (C3-6)cycloalkyl.
    Type: Application
    Filed: April 6, 2017
    Publication date: September 21, 2017
    Inventors: Rosemarie MANG, Werner HEILMAYER, Rudolf BADEGRUBER, Dirk B. STRICKMANN, Rodger NOVAK, Mathias FERENCIC, Atchyuta Rama Chandra Murty BULUSU
  • Publication number: 20140256731
    Abstract: Pleuromutilin derivative compounds of the following formula, and uses thereof for the treatment of diseases mediated by microbes, are disclosed:
    Type: Application
    Filed: May 21, 2014
    Publication date: September 11, 2014
    Applicant: NABRIVA THERAPEUTICS AG
    Inventors: Rosemarie MANG, Werner HEILMAYER, Rudolf BADEGRUBER, Dirk B. STRICKMANN, Rodger NOVAK, Mathias FERENCIC, Atchyuta Rama Chandra Murty BULUSU
  • Publication number: 20130040954
    Abstract: Pleuromutilin derivative compounds of the following formula, and uses thereof for the treatment of diseases mediated by microbes, are disclosed:
    Type: Application
    Filed: April 3, 2012
    Publication date: February 14, 2013
    Inventors: Rosemarie MANG, Werner HEILMAYER, Rudolf BADEGRUBER, Dirk B. STRICKMANN, Rodger NOVAK, Mathias FERENCIC, Atchyuta Rama Chandra Murty BULUSU
  • Patent number: 8343972
    Abstract: The present invention relates to compounds selected from the group consisting of 14-0-[((Mono- or dialkylamino)-cycloalkylsulfanyl- or -cycloalkyl-oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, 14-O-[((Cycloalkyl- or heterocyclylamino)-cycloalkylsulfanyl- or -cycloalkyl-oxy)-acetyl, -thioaceyl or -imino-oxy]-mutilins, 14-O-[((Heterocyc-N-yl-cycloalkyl)-sulfanyl- or -oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, 14-O-[(((Mono- or dialkylamino)-cycloalkyl)-alkylsulfanyl- or -alkyl-oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, 14-O-[(((Cycloalkyl- or heterocyclylamino)-cycloalkyl)-alkylsulfanyl- or -alkyl-oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, and 14-O-[((Heterocyc-N-yl-cycloalkyl)-alkylsulfanyl- or -alkyl-oxy)-acetyl, -thioacetyl or -imino-oxy]-mutilins, and their use as pharmaceuticals.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: January 1, 2013
    Assignee: Nabriva Therapeutics AG
    Inventors: Rosemarie Mang, Heinz Berner
  • Patent number: 8222447
    Abstract: Compounds of formula (I), which are 14-O-{[(optionally substituted hydroxy)cyclohexyl)sulfanyl]acetyl}mutilins further substituted at the cyclohexyl group by an acylated amino group, salts and solvates thereof, pharmaceutical compositions comprising such compounds and their use as a pharmaceutical, e.g. for the treatment of diseases mediated by microbes and for the treatment of inflammation where microbes are mediating said inflammation.
    Type: Grant
    Filed: August 17, 2009
    Date of Patent: July 17, 2012
    Assignee: Nabriva Therapeutics AG
    Inventors: Rosemarie Mang, Werner Heilmayer
  • Patent number: 8153689
    Abstract: Disclosed are pleuromutilin derivatives of formula (I) and their use in the treatment of diseases mediated by microbes.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: April 10, 2012
    Assignee: Nabriva Therapeutics AG
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk B. Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20120046276
    Abstract: A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.
    Type: Application
    Filed: October 25, 2011
    Publication date: February 23, 2012
    Applicant: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Heinz Berner, Rosemarie Mang
  • Publication number: 20120029072
    Abstract: Disclosed are pleuromutilin derivatives of formula (I) an their use in the treatment of diseases mediated by microbes.
    Type: Application
    Filed: October 4, 2011
    Publication date: February 2, 2012
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk B. Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Patent number: 8088823
    Abstract: A method of preventing or treating diseases caused by Mycobacterium, comprising administering to a subject in need of such treatment an effective amount of a pleuromutilin.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: January 3, 2012
    Assignee: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Heinz Berner, Rosemarie Mang
  • Patent number: 8071643
    Abstract: A pleuromutilin derivative compound of general formula (I)
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: December 6, 2011
    Assignee: Nabriva Therapeutics AG
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk B. Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20110184022
    Abstract: Compounds of formula (I), which are 14-O-{[(optionally substituted hydroxy)cyclohexyl)sulfanyl]acetyl}mutilins further substituted at the cyclohexyl group by an acylated amino group, salts and solvates thereof, pharmaceutical compositions comprising such compounds and their use as a pharmaceutical, e.g. for the treatment of diseases mediated by microbes and for the treatment of inflammation where microbese are mediating said inflammation.
    Type: Application
    Filed: August 17, 2009
    Publication date: July 28, 2011
    Applicant: NABRIVA THERAPEUTICS AG
    Inventors: Rosemarie Mang, Werner Heilmayer
  • Patent number: 7790767
    Abstract: The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R1 is hydroxy or acyloxy, or R is acyl and R1 is hydroxy or acyloxy, X is sulphur, oxygen or NR10, wherein R10 is hydrogen or (C1-4)alkyl; Y is sulphur or oxygen; R2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; R4 is hydrogen or (C1-4)alkyl; R5 is hydrogen or (C1-4)alkyl; R3 and R3? are hydrogen, deuterium, or halogen; R6, R7 and R8 are hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usefül as pharmaceuticals, particularly as antimicrobials.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: September 7, 2010
    Assignee: Nabriva Therapeutics Forschungs GmbH
    Inventors: Rosemarie Mang, Gerd Ascher, Mathias Ferencic, Werner Heilmayer, Rodger Novak
  • Publication number: 20100035987
    Abstract: A pleuromutilin derivative compound of general formula (I)
    Type: Application
    Filed: March 19, 2008
    Publication date: February 11, 2010
    Applicant: NABRIVA THERAPEUTICS AG
    Inventors: Rosemarie Mang, Werner Heilmayer, Rudolf Badegruber, Dirk B. Strickmann, Rodger Novak, Mathias Ferencic, Atchyuta Rama Chandra Murty Bulusu
  • Publication number: 20090306203
    Abstract: The present invention relates to Compounds of general formula (I), wherein R is hydrogen and R1 is hydroxy or acyloxy, or R is acyl and R1 is hydroxy or acyloxy, X is sulphur, oxygen or NR10, wherein R10 is hydrogen or (C1-4)alkyl; Y is sulphur or oxygen; R2 is hydrogen or one or more substituents, e.g. including substituents such as conventional in organic, e.g. (pleuro)mutilin, chemistry; R4 is hydrogen or (C1-4)alkyl; R5 is hydrogen or (C1-4)alkyl; R3 and R3? are hydrogen, deuterium, or halogen; R6, R7 and R8 are hydrogen, halogen or deuterium; m is a number selected from 0 to 4, n is a number selected from 0 to 10, and p is a number selected from 0 to 10; with the proviso that n plus p are at least 1. These Compounds are usefül as pharmaceuticals, particularly as antimicrobials.
    Type: Application
    Filed: June 26, 2006
    Publication date: December 10, 2009
    Applicant: Nabriva Therapeutics Forschungs GmbH
    Inventors: Rosemarie Mang, Gerd Ascher, Mathias Ferencic, Werner Heilmayer, Rodger Novak