Patents by Inventor Ross Durland

Ross Durland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of X-aptamer generation and compositions thereof
    Patent number: 9988623
    Abstract: Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any position along the sequence because the aptamers are chemically synthesized via a split-pool scheme on individual beads. Also provides are application to a wide range of commonly used DNA modifications, including, but not limited to, monothioate and dithioate backbone substitutions. This new class of aptamer allows chemical modifications introduced to any of the bases in the aptamer sequence as well as the phosphate backbones and can be extended to other carbohydrate-based systems.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: June 5, 2018
    Assignees: AM Biotechnologies, LLC, Board of Regents of the University of Texas System
    Inventors: David G Gorenstein, Weiguo He, David E Volk, Miguel-Angel Elizondo-Riojas, Ross Durland, Johnnie Engelhardt
  • METHODS OF X-APTAMER GENERATION AND COMPOSITIONS THEREOF
    Publication number: 20140100120
    Abstract: Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any position along the sequence because the aptamers are chemically synthesized via a split-pool scheme on individual beads. Also provides are application to a wide range of commonly used DNA modifications, including, but not limited to, monothioate and dithioate backbone substitutions. This new class of aptamer allows chemical modifications introduced to any of the bases in the aptamer sequence as well as the phosphate backbones and can be extended to other carbohydrate-based systems.
    Type: Application
    Filed: October 10, 2013
    Publication date: April 10, 2014
    Inventors: David G Gorenstein, Weiguo He, David E Volk, Miquel-Angel Elizondo-Riojas, Ross Durland, Johnnie Engelhardt
  • Process and equipment for plasmid purification
    Patent number: 8236495
    Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.
    Type: Grant
    Filed: January 9, 2006
    Date of Patent: August 7, 2012
    Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuowei Wu, Rexford Hayes
  • Process and equipment for plasmid purfication
    Publication number: 20060106208
    Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.
    Type: Application
    Filed: January 9, 2006
    Publication date: May 18, 2006
    Applicant: Valentis, Inc
    Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes
  • Process and equipment for plasmid purification
    Patent number: 7026468
    Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cell. Effective, contgrollable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and nuetralization.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: April 11, 2006
    Assignee: Valentis, Inc.
    Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes
  • Process and equipment for plasmid purification
    Publication number: 20010034435
    Abstract: A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cells. Effective, controllable, and economical operation, and consistent low level of host chromosomal DNA in the final plasmid product. Involves a series of new unit operations and devices for cell resuspension, cell lysis, and neutralization.
    Type: Application
    Filed: January 29, 2001
    Publication date: October 25, 2001
    Applicant: Valentis, Inc.
    Inventors: Samuel Nochumson, Ross Durland, Audrey Yu-Speight, John Welp, Kuoewi Wu, Rexford Hayes