Abstract: The monitoring and control of bioprocesses is provided. The present disclosure provides the ability to generate generic calibration models, independent of cell line, using inline Raman probes to monitor changes in glucose, lactate, glutamate, ammonium, viable cell concentration (VCC), total cell concentration (TCC) and product concentration. Calibration models were developed from cell culture using two different CHOK1SV GS-KO™ cell lines producing different monoclonal antibodies (mAbs). Developed predictive models, qualified using an independent CHOK1SV GS-KO™ cell line not used in calibration, measured changes in glucose, lactate, ammonium, VCC, and TCC with minor prediction errors over the course of cell culture with minimal cell line dependence. The development of these generic models allows the application of spectroscopic PAT techniques in a clinical manufacturing environment, where processes are typically run once or twice in GMP manufacturing based on a common platform process.

Abstract: The monitoring and control of bioprocesses is provided. The present disclosure provides the ability to generate generic calibration models, independent of cell line, using inline Raman probes to monitor changes in glucose, lactate, glutamate, ammonium, viable cell concentration (VCC), total cell concentration (TCC) and product concentration. Calibration models were developed from cell culture using two different CHOK1SV GS-KO™ cell lines producing different monoclonal antibodies (mAbs). Developed predictive models, qualified using an independent CHOK1SV GS-KO™ cell line not used in calibration, measured changes in glucose, lactate, ammonium, VCC, and TCC with minor prediction errors over the course of cell culture with minimal cell line dependence. The development of these generic models allows the application of spectroscopic PAT techniques in a clinical manufacturing environment, where processes are typically run once or twice in GMP manufacturing based on a common platform process.

Abstract: An antenna system for use with one or more media devices is provided. The antenna system includes a plurality of antenna elements. Each antenna element is associated with an independent feed element. In addition each antenna element is configured to receive a plurality of radio frequency (RF) signals. Each RF signal can be associated with a UHF band or a VHF band. The antenna system can include at least one tuner and at least one switching device. The at least one switching device can be configured to selectively couple the at least one tuner to one antenna element of the plurality of antenna elements based, at least in part, on channel selection data associated with the at least one tuner.

Abstract: An active antenna for UHF/VHF signal receiving is described, the active antenna being capable of configuration in one of a plurality of possible modes. The active antenna includes an antenna element configured for multiple resonances in the UHF/VHF bands, and capable of generating multiple radiation modes as well as active impedance matching using a microprocessor and multi-port switch having variable or multiple selectable modes. The active antenna may include a second antenna element arranged in a right-angle orientation with respect to the first antenna element. The first antenna element, second antenna element, or a combination may be selected for receiving signals in at a desired frequency. A three-dimensional antenna assembly is also described. Each of the examples illustrate an active beam steering antenna capable of UHF/VHF signal receiving.

Abstract: An antenna system for use with one or more media devices is provided. The antenna system includes a plurality of antenna elements. Each antenna element is associated with an independent feed element. In addition each antenna element is configured to receive a plurality of radio frequency (RF) signals. Each RF signal can be associated with a UHF band or a VHF band. The antenna system can include at least one tuner and at least one switching device. The at least one switching device can be configured to selectively couple the at least one tuner to one antenna element of the plurality of antenna elements based, at least in part, on channel selection data associated with the at least one tuner.

Abstract: An antenna system for use with one or more media devices is provided. The antenna system includes a plurality of antenna elements. Each antenna element is associated with an independent feed element. In addition each antenna element is configured to receive a plurality of radio frequency (RF) signals. Each RF signal can be associated with a UHF band or a VHF band. The antenna system can include at least one tuner and at least one switching device. The at least one switching device can be configured to selectively couple the at least one tuner to one antenna element of the plurality of antenna elements based, at least in part, on channel selection data associated with the at least one tuner.

Abstract: An active antenna for UHF/VHF signal receiving is described, the active antenna being capable of configuration in one of a plurality of possible modes. The active antenna includes an antenna element configured for multiple resonances in the UHF/VHF bands, and capable of generating multiple radiation modes as well as active impedance matching using a microprocessor and multi-port switch having variable or multiple selectable modes. The active antenna may include a second antenna element arranged in a right-angle orientation with respect to the first antenna element. The first antenna element, second antenna element, or a combination may be selected for receiving signals in at a desired frequency. A three-dimensional antenna assembly is also described. Each of the examples illustrate an active beam steering antenna capable of UHF/VHF signal receiving.

Abstract: An antenna system for use with one or more media devices is provided. The antenna system includes a plurality of antenna elements. Each antenna element is associated with an independent feed element. In addition each antenna element is configured to receive a plurality of radio frequency (RF) signals. Each RF signal can be associated with a UHF band or a VHF band. The antenna system can include at least one tuner and at least one switching device. The at least one switching device can be configured to selectively couple the at least one tuner to one antenna element of the plurality of antenna elements based, at least in part, on channel selection data associated with the at least one tuner.

Abstract: An active antenna for UHF/VHF signal receiving is described, the active antenna being capable of configuration in one of a plurality of possible modes. The active antenna includes an antenna element configured for multiple resonances in the UHF/VHF bands, and capable of generating multiple radiation modes as well as active impedance matching using a microprocessor and multi-port switch having variable or multiple selectable modes. The active antenna may include a second antenna element arranged in a right-angle orientation with respect to the first antenna element. The first antenna element, second antenna element, or a combination may be selected for receiving signals in at a desired frequency. A three-dimensional antenna assembly is also described. Each of the examples illustrate an active beam steering antenna capable of UHF/VHF signal receiving.

Abstract: The monitoring and control of bioprocesses is provided. The present disclosure provides the ability to generate generic calibration models, independent of cell line, using inline Raman probes to monitor changes in glucose, lactate, glutamate, ammonium, viable cell concentration (VCC), total cell concentration (TCC) and product concentration. Calibration models were developed from cell culture using two different CHOK1SV GS-KO™ cell lines producing different monoclonal antibodies (mAbs). Developed predictive models, qualified using an independent CHOK1SV GS-KO™ cell line not used in calibration, measured changes in glucose, lactate, ammonium, VCC, and TCC with minor prediction errors over the course of cell culture with minimal cell line dependence. The development of these generic models allows the application of spectroscopic PAT techniques in a clinical manufacturing environment, where processes are typically run once or twice in GMP manufacturing based on a common platform process.

Abstract: An active antenna for UHF/VHF signal receiving is described, the active antenna being capable of configuration in one of a plurality of possible modes. The active antenna includes an antenna element configured for multiple resonances in the UHF/VHF bands, and capable of generating multiple radiation modes as well as active impedance matching using a microprocessor and multi-port switch having variable or multiple selectable modes. The active antenna may include a second antenna element arranged in a right-angle orientation with respect to the first antenna element. The first antenna element, second antenna element, or a combination may be selected for receiving signals in at a desired frequency. A three-dimensional antenna assembly is also described. Each of the examples illustrate an active beam steering antenna capable of UHF/VHF signal receiving.

Abstract: A multi-frequency antenna comprising an IMD element, one or more active tuning elements and one or more parasitic elements. The IMD element is used in combination with the active tuning and parasitic elements for enabling a variable frequency at which the antenna operates, wherein, when excited, the parasitic elements may couple with the IMD element to change an operating characteristic of the IMD element.

Abstract: A multi-frequency antenna comprising an IMD element, one or more active tuning elements and one or more parasitic elements. The IMD element is used in combination with the active tuning and parasitic elements for enabling a variable frequency at which the antenna operates, wherein, when excited, the parasitic elements may couple with the IMD element to change an operating characteristic of the IMD element.

Abstract: A multi-frequency antenna comprising an IMD element, one or more active tuning elements and one or more parasitic elements. The IMD element is used in combination with the active tuning and parasitic elements for enabling a variable frequency at which the antenna operates, wherein, when excited, the parasitic elements may couple with the IMD element to change an operating characteristic of the IMD element.

Abstract: A multi-frequency antenna comprising an IMD element, one or more active tuning elements and one or more parasitic elements. The IMD element is used in combination with the active tuning and parasitic elements for enabling a variable frequency at which the antenna operates, wherein, when excited, the parasitic elements may couple with the IMD element to change an operating characteristic of the IMD element.

Abstract: A multi-frequency antenna comprising an IMD element, one or more active tuning elements and one or more parasitic elements. The IMD element is used in combination with the active tuning and parasitic elements for enabling a variable frequency at which the antenna operates, wherein, when excited, the parasitic elements may couple with the IMD element to change an operating characteristic of the IMD element.

Abstract: An antenna includes one or more antenna elements and a volume of material contained at least partly within a volume of the one or more antenna elements. The volume of material has at least one electromagnetic property that is different from free space. The volume of material may include dielectric material and/or ferrite material. The antenna elements may be isolated magnetic dipole (IMD) antenna elements. The electromagnetic property may be permeability and/or permittivity.

Abstract: A multi-frequency antenna comprising an IMD element, one or more active tuning elements and one or more parasitic elements. The IMD element is used in combination with the active tuning and parasitic elements for enabling a variable frequency at which the antenna operates, wherein, when excited, the parasitic elements may couple with the IMD element to change an operating characteristic of the IMD element.

Abstract: A multi-frequency antenna comprising an IMD element, active tuning elements and parasitic elements. The IMD element is used in combination with the active tuning and parasitic elements for enabling a variable frequency at which the antenna operates, wherein, when excited, the parasitic elements may couple with the IMD element to change an operating characteristic of the IMD element.

Abstract: A multi-layer isolated magnetic dipole (IMD) with improved bandwidth and efficiency characteristics to be used in wireless communications and other applicable systems. The multi-layer IMD antenna comprises an IMD element positioned above a ground plane, a conductive element positioned above a ground plane and coupled to the first portion having one or more slot regions being defined between the IMD element and the conductive element and one or more capacitive elements positioned across the one or more slot regions. The range of frequencies covered to be determined by the shape, size, and number of elements in the physical configuration of the components.