Abstract: An improvised anthroplastic prosthetic implant having, in some embodiments, secondary screws with threaded shafts for forming pilot holes into the resected cancellous bone surface, such as the tibia, and primary screws with tapered heads for replacing the secondary screws and forming a Morse friction fit with the implant and seating the implant in close apposition to, and at less than 150 um in, resected bone thereby facilitating implant stability, wherein the heads of the primary screws are recessed into a counterbore in the baseplate to improve axial postoperative stability of the implant.

Abstract: An improvised anthroplastic prosthetic implant having, in some embodiments, secondary screws with threaded shafts for forming pilot holes into the resected cancellous bone surface, such as the tibia, and primary screws with tapered heads for replacing the secondary screws and forming a Morse friction fit with the implant and seating the implant in close apposition to, and at less than 150 um in, resected bone thereby facilitating implant stability, wherein the heads of the primary screws are recessed into a counterbore in the baseplate to improve axial postoperative stability of the implant.

Abstract: A medical device that includes a coating of a composite material that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 ?m, 50 nm to 10 ?m, 100 nm to 5 ?m, or 1 ?m to 10 ?m. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.

Abstract: An antimicrobial containment cap is provided for use in a bone anchored prosthesis mounting system of the type having an externally protruding fixator pin carried by implanted bone anchored mounting post, wherein the fixator pin accommodates removable attachment to an exoskeletal prosthesis such as a prosthetic limb or the like for an amputee. The containment cap, when mounted onto the fixator pin, is interposed between the prosthesis and soft tissue covering the end or stump of an amputated residual limb or the like. The containment cap carries and supports a selected antimicrobial or antibacterial agent in substantial contact with the soft stump tissue in a position closely overlying and substantially circumscribing the tissue interface with the externally protruding fixator pin to safeguard against infection. The containment cap is adapted for quick and easy periodic removal for cleaning and/or replenishment of the antimicrobial agent.

Abstract: A medical device that includes a coating of a composite material that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 ?m, 50 nm to 10 ?m, 100 nm to 5 ?m, or 1 ?m to 10 ?m. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.

Abstract: An antimicrobial containment cap is provided for use in a bone anchored prosthesis mounting system of the type having an externally protruding fixator pin carried by all implanted bone anchored mounting post, wherein the fixator pin accommodates removable attachment to an exoskeletal prosthesis such as a prosthetic limb or the like for an amputee. The containment cap, when mounted onto the fixator pin, is interposed between the prosthesis and soft tissue covering the end or stump of an amputated residual limb or the like. The containment cap carries and supports a selected antimicrobial or antibacterial agent in substantial contact with the soft stump tissue in a position closely overlying and substantially circumscribing the tissue interface with the externally protruding fixator pin to safeguard against infection. The containment cap is adapted for quick and easy periodic removal for cleaning and/or replenishment of the antimicrobial agent.

Abstract: An intervertebral milling instrument for removing calcified fibrous cartilage (CFC) from adjacent vertebrae during spinal fusion or spacer implantation surgery. The milling instrument includes a grinding wheel carried within a guide housing sized to fit closely into the intervertebral space, and to expose the grinding wheel on opposite sides thereof for controlled removal of CFC layers from adjacent cortical end plates. The grinding wheel is rotatably driven as by attachment to a surgical drill, preferably to include saline supply to and suction removal from the grinding site. The controlled removal of CFC layers is limited to about 100 to about 250 microns, thereby avoiding exposing the cortical end plates without excessive bone removal. The instrument is conveniently provided in a kit having multiple guide housings and associated grinding wheels of different sizes to fit into different intervertebral spaces.

Abstract: An osseointegrated implant for an amputee includes a surgically implanted post-shaped orthopedic implant rigidly supported by patient bone, wherein the implant protrudes through overlying stump tissue to an external location for suitable attachment to a prosthetic limb or the like. A non-invasive electrical stimulation system provides controlled electrical stimulation at the implant-bone interface for achieving rapid and secure fixation by osseointegration in a significantly reduced rehabilitation time. The electrical stimulation system utilizes at least one and preferably multiple electrodes mounted externally onto the patient in close proximity to the implant-bone interface, with an external portion of the implant providing a second electrode. In one preferred form, the implant comprises a base structure of titanium or titanium alloy or the like, coated with a thin film of a highly conductive substance such as gold for improved electrical conductivity.

Abstract: An antimicrobial containment cap is provided for use in a bone anchored prosthesis mounting system of the type having an externally protruding fixator pin carried by all implanted bone anchored mounting post, wherein the fixator pin accommodates removable attachment to an exoskeletal prosthesis such as a prosthetic limb or the like for an amputee. The containment cap, when mounted onto the fixator pin, is interposed between the prosthesis and soft tissue covering the end or stump of an amputated residual limb or the like. The containment cap carries and supports a selected antimicrobial or antibacterial agent in substantial contact with the soft stump tissue in a position closely overlying and substantially circumscribing the tissue interface with the externally protruding fixator pin to safeguard against infection. The containment cap is adapted for quick and easy periodic removal for cleaning and/or replenishment of the antimicrobial agent.

Abstract: A prosthetic joint and related placement method are provided for cemented fixation to a prepared patient bone, with a cement layer and mantle of controlled, predetermined thickness. The prosthetic component such as a tibial or femoral component for a knee prosthesis includes an attachment surface bounded by a flow restrictor wall which cooperates with the attachment surface to define an open-sided cavity for receiving a quantity of bone cement. An intruder tool is provided to form a shallow recess in the prepared patient bone for mating seated reception of the flow restrictor wall on the prosthetic component. In one form, the prosthetic component and the intruder tool may be adjustable to fit patient bones of different size.

Abstract: A prosthetic joint component and related placement method are provided for cemented fixation to a prepared patient bone, with a cement layer and mantle of controlled, predetermined thickness. The prosthetic component, such as a tibial or femoral component for a knee prosthesis, includes an attachment surface with a plurality of spacer pegs protruding therefrom, and bounded by a taller flow restrictor wall which cooperates with the shorter spacer pegs and attachment surface to define an open-sided cavity for receiving a quantity of bone cement. An intruder tool is provided to form a shallow recess in the prepared patient bone for seated reception of the flow restrictor wall on the prosthetic component.

Abstract: An improved prosthesis particularly for use as a knee joint is designed for secure ingrowth attachment to cancellous bone and adjacent tissue without use of bone cement. The prosthesis comprises a tibial component and a femoral component shaped to accommodate articulatory knee joint motion and each including a base surface adapted for enhanced bone ingrowth attachment to cancellous bone of a resected tibia and femur, respectively. The base surface of each component includes an extended surface area protruding into a region of cancellous bone and subdivided into a plurality of attachment zones coated with a selected porous bone ingrowth material, wherein these attachment zones are bounded by uncoated shallow channels for draining fluid from the attachment interface to the exterior of the prosthesis.

Abstract: An improved tibial component is provided for a knee prosthesis, wherein the tibial component includes a pair of tibial tray members adapted to accommodate independent longitudinal shifting during patient function while retaining a secure and stable fixation with respect to patient bone. The two tibial tray members comprise medial and lateral members for supporting the medial and laternal condyles of a knee joint. These tray members are interconnected by a slide key arrangement which restrains the tibial tray members against relative movement in the anterior-posterior and medial-lateral directions, while permitting relative shifting in a longitudinal direction corresponding generally with a central axis of the patient's tibia. In the preferred form, the two tibial tray members cooperatively define a common anchoring post and include one or more antirotation fins for mechanically locking with patient bone.

Abstract: A physiologically conforming solution for use in invasive medical procedures which is hypertonic with respect to blood serum and may, in fact, have a higher osmolality than synovial fluid. The solution is of particular utility as an irrigant in arthroscopic surgery in order to reduce the risk of swelling and injury of the synovial tissues and as a therapeutic treatment for swelling and subsequent inflammation of joints and soft tissue which occurs in certain traumatized and pathological states.

Abstract: An improved prosthesis particularly for use as a knee joint is designed for secure ingrowth attachment to cancellous bone and adjacent tissue without use of bone cement. The prosthesis comprises a tibial component and a femoral component shaped to accommodate articulatory knee joint motion and each including a base surface adapted for enhanced bone ingrowth attachment to cancellous bone of a resected tibia and femur, respectively. The base surface of each component includes an extended surface area protruding into a region of cancellous bone and subdivided into a plurality of attachment zones coated with a selected porous bone ingrowth material, wherein these attachment zones are bounded by uncoated shallow channels for draining fluid from the attachment interface to the exterior of the prosthesis.