Abstract: A full-thickness resection system comprises a flexible endoscope and a stapling mechanism, wherein the endoscope is slidably received through at least a portion of the stapling mechanism. The stapling mechanism comprises an anvil and a stapling head mounted to the anvil so that the anvil and the stapling head are moveable with respect to one another between a tissue receiving position and a stapling position and wherein a gap formed between the stapling head and the anvil is larger in the tissue receiving position than it is in the stapling position. A position adjusting mechanism is provided for moving the anvil and the stapling head between the tissue receiving and stapling positions and a staple firing mechanism sequentially fires a plurality of staples from the stapling head across the gap against the anvil and through any tissue received in the gap and a knife cuts a portion of tissue received within the gap.

Abstract: A full-thickness resection system comprises a flexible endoscope and a stapling mechanism, wherein the endoscope is slidably received through at least a portion of the stapling mechanism. The stapling mechanism comprises an anvil and a stapling head mounted to the anvil so that the anvil and the stapling head are moveable with respect to one another between a tissue receiving position and a stapling position and wherein a gap formed between the stapling head and the anvil is larger in the tissue receiving position than it is in the stapling position. A position adjusting mechanism is provided for moving the anvil and the stapling head between the tissue receiving and stapling positions and a staple firing mechanism sequentially fires a plurality of staples from the stapling head across the gap against the anvil and through any tissue received in the gap and a knife cuts a portion of tissue received within the gap.

Abstract: Apparatus for needle grasping and performing a second modality comprising a sheath axially extending between distal and proximal ends thereof. The device includes an inner hollow tube with a slot formed therein for receiving a needle at the distal end. Retraction and extension of the inner tubular member relative to the sheath enable the grasping and releasing of a suture needle received in the slot. A handle is provided at the proximal end of the apparatus for selectively extending and retracting the inner tube relative to the sheath and for retaining the inner tube in its extended and retracted positions. A second switch can be provided in the handle to actuate a catheter slidably inserted through the inner tube to perform a second therapeutic modality. The catheter preferably includes a distal bight that forms a loop when extended from the distal end of the sheath for facilitating intracorporeal knot tying thereat.

Abstract: Apparatus for needle grasping and performing a second modality comprising a sheath axially extending between distal and proximal ends thereof. The device includes an inner hollow tube with a slot formed therein for receiving a needle at the distal end. Retraction and extension of the inner tubular member relative to the sheath enable the grasping and releasing of a suture needle received in the slot. A handle is provided at the proximal end of the apparatus for selectively extending and retracting the inner tube relative to the sheath and for retaining the inner tube in its extended and retracted positions. A second switch can be provided in the handle to actuate a catheter slidably inserted through the inner tube to perform a second therapeutic modality. The catheter preferably includes a distal bight that forms a loop when extended from the distal end of the sheath for facilitating intracorporeal knot tying thereat.

Abstract: A catheter for the administration of a liquid agent at a target site includes a catheter tube, a handle and a conduit that extends through a central volume formed in the handle. The catheter includes a guidewire lumen and two parallel liquid agent transfer lumens. The conduit seals into the proximal end of the guidewire lumen and to the handle at a first entry port and spans the central volume. The tube therefore prevents the transfer of any liquid agent into the guidewire lumen and provides a passageway for enabling the catheter to transfer over the guidewire. With two transfer lumens the catheter tube provides a maximum transfer flow rate while maintaining the ability of the catheter to resist kinking and bending.

Abstract: An integrated catheter assembly for enabling diverse in situ therapies includes a catheter with an irrigation fluid lumen, a distal tip portion that acts as a hemostat and a needle for injection therapy that extends through the catheter lumen and a lumen in the distal tip portion. A needle hub structure carries the catheter and provides a sealing entrance for a needle that can be displaced between extended and retracted positions. The needle and electrodes are electrically isolated. The apparatus provides a physician the options of irrigating tissue, cauterizing tissue or injecting tissue without the need for removing the apparatus from the working channel of an endoscope.

Abstract: An integrated catheter assembly for enabling diverse in situ therapies includes a catheter with an irrigation fluid lumen, a distal tip portion that acts as a hemostat and a needle for injection therapy that extends through the catheter lumen and a lumen in the distal tip portion. A needle hub structure carries the catheter and provides a sealing entrance for a needle that can be displaced between extended and retracted positions. The needle and electrodes are electrically isolated. The apparatus provides a physician the options of irrigating tissue, cauterizing tissue or injecting tissue without the need for removing the apparatus from the working channel of an endoscope.