Abstract: A diffusion cell to facilitate the automatic or manual removal of test aliquots of liquid from a receptor chamber of the diffusion cell so as to determine percantaneous absorption through a membrane of a substance from a donor chamber into a receptor chamber of the diffusion cell. There is utilized a capillary port through which the test aliquot is to be removed. A refilling tube connects also with the receptor chamber to add receptor liquid into the receptor chamber as the test aliquot is being removed. A quick release clamping apparatus secures the donor housing which contains the donor chamber tightly to the main housing of the diffusion cell.

Abstract: A diffusion cell to facilitate the automatic or manual removal of test aliquots of liquid from a receptor chamber of the diffusion cell so as to determine percantaneous absorption through a membrane of a substance from a donor chamber into a receptor chamber of the diffusion cell. There is utilized a capillary port through which the test aliquot is to be removed. A refilling tube connects also with the receptor chamber to add receptor liquid into the receptor chamber as the test aliquot is being removed. A quick release clamping apparatus secures the donor housing which contains the donor chamber tightly to the main housing of the diffusion cell.

Abstract: A dissolution sampling apparatus which automatically extracts aliquots which contain a dissolved drug in solution from a plurality of dissolution containing flasks and tests each aliquot for the amount of drug dissolved within the aliquot. The sampling apparatus can resupply the removed aliquot. back to its source or the aliquot can be discarded as waste with new media being resupplied to the source. A syringe is used to remove the aliquots. A mechanically operated valve could be used with each syringe or a plurality of solenoids instead of the mechanically operated valve.

Abstract: A dissolution test apparatus which utilizes a fixed base upon which is movably mounted a drive head. The fixed base which supports a plurality of flasks. Mounted within the drive head are a plurality of mixing paddles. The drive head is to be manually movable from the upper position to a lower position. In the lower position each mixing paddle to be located within a flask. Also mounted in the drive head is a plurality of sample tubes with a sample tube to be located in direct juxtaposition to a mixing paddle. Each sample tube is separately movable relative to the drive head. With the drive head in the upper position the mixing paddles are located spaced from their respective flasks. The weight of the drive head is counterbalanced by a counterbalancing weight assembly. A caliper type of braking arrangement is mounted on the drive head and when in the at-rest position the drive head is fixedly positioned relative to the base.

Abstract: A dissolution test apparatus which utilizes a fixed base upon which is movably mounted a drive head, The fixed base which supports a plurality of flasks. Mounted within the drive head are a plurality of mixing paddles, The drive head is to be manually movable from the upper position to a lower position, In the lower position each mixing paddle to be located within a flask. Also mounted in the drive head is a plurality of sample tubes with a sample tube to be located in direct juxtaposition to a mixing paddle, Each sample tube is separately movable relative to the drive head. With the drive head in the upper position the mixing paddles are located spaced from their respective flasks. The weight of the drive head is counterbalanced by a counterbalancing weight assembly. A caliper type of braking arrangement is mounted on the drive head and when in the at-rest position the drive head is fixedly positioned relative to the base.