Patents by Inventor Ruben M. Sandoval
Ruben M. Sandoval has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220214349Abstract: Disclosed are methods for determining biometric indicators such as plasma volume, hematocrit and glomerular filtration rate, in mammalian subjects such as humans. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule, or wherein the static molecule is labeled with a fluorescent tag and a dynamic molecule is labeled with another fluorescent tag. One or more measurements of the intensities of the fluorescent emissions are taken subsequent to introduction of an injectate which contains the fluorescent tags, which can be taken using a probe or via a blood or plasma sample. Compositions and apparatuses for practicing the methods are also disclosed.Type: ApplicationFiled: October 18, 2021Publication date: July 7, 2022Inventors: Daniel J. MEIER, Ruben M. SANDOVAL, JR., Erinn REILLY
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Patent number: 10555961Abstract: Various aspects relate to the use of C-1 gentamicin as an antibiotic effective for the treatment of a bacterial infection, a genetic disorder, or cancer in a subject.Type: GrantFiled: June 3, 2016Date of Patent: February 11, 2020Assignees: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION, UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRSInventors: Bruce A. Molitoris, Mark C. Wagner, Ruben M. Sandoval, Mark Gerard Goebl
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Publication number: 20180180622Abstract: Disclosed are methods for determining biometric indicators such as plasma volume, hematocrit and glomerular filtration rate, in mammalian subjects such as humans. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule, or wherein the static molecule is labeled with a fluorescent tag and a dynamic molecule is labeled with another fluorescent tag. One or more measurements of the intensities of the fluorescent emissions are taken subsequent to introduction of an injectate which contains the fluorescent tags, which can be taken using a probe or via a blood or plasma sample. Compositions and apparatuses for practicing the methods are also disclosed.Type: ApplicationFiled: June 24, 2016Publication date: June 28, 2018Applicant: PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICALInventors: Daniel J. Meier, Ruben M. Sandoval, Jr., Erinn Reilly
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Publication number: 20180147229Abstract: Various aspects relate to the use of C-1 gentamicin as an antibiotic effective for the treatment of a bacterial infection, a genetic disorder, or cancer in a subject.Type: ApplicationFiled: June 3, 2016Publication date: May 31, 2018Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: Bruce A. MOLITORIS, Mark C. WAGNER, Ruben M. SANDOVAL, Mark Gerard GOEBL
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Patent number: 9775854Abstract: Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts to treat diseases that involve genetic mutations which introduce a missense or premature stop codon into a gene. Still other aspects include treating human or animal patients with the gentamicin congener C2 and derivatives and pharmaceutical salt thereof to overcome, or to at least mitigate, the symptoms of disease and disorders such as some forms of Becker's or Duchenne muscular dystrophy, Hurler's Syndrome and Cystic Fibrosis that have as their etiology the presence of a premature stop codon in a gene whose proper expression is necessary for good health.Type: GrantFiled: January 5, 2015Date of Patent: October 3, 2017Assignees: Indiana University Research and Technology Corporation, UAB Research FoundationInventors: Bruce A. Molitoris, David M. Bedwell, Ruben M. Sandoval
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Patent number: 9744249Abstract: A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.Type: GrantFiled: May 16, 2016Date of Patent: August 29, 2017Assignee: Indiana University Research and Technology CorporationInventors: Weiming Yu, Bruce A. Molitoris, Ruben M. Sandoval
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Publication number: 20170173188Abstract: The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV?TVPV.Type: ApplicationFiled: March 12, 2015Publication date: June 22, 2017Inventors: Bruce A. Molitoris, Exing Wang, Ruben M. Sandoval, Jr.
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Publication number: 20160256574Abstract: A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.Type: ApplicationFiled: May 16, 2016Publication date: September 8, 2016Inventors: Weiming YU, Bruce A. MOLITORIS, Ruben M. SANDOVAL
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Patent number: 9352054Abstract: A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.Type: GrantFiled: April 16, 2014Date of Patent: May 31, 2016Assignee: Indiana University Research and Technology CorporationInventors: Weiming Yu, Bruce A. Molitoris, Ruben M. Sandoval
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Publication number: 20150182545Abstract: Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts to treat diseases that involve genetic mutations which introduce a missense or premature stop codon into a gene. Still other aspects include treating human or animal patients with the gentamicin congener C2 and derivatives and pharmaceutical salt thereof to overcome, or to at least mitigate, the symptoms of disease and disorders such as some forms of Becker's or Duchenne muscular dystrophy, Hurler's Syndrome and Cystic Fibrosis that have as their etiology the presence of a premature stop codon in a gene whose proper expression is necessary for good health.Type: ApplicationFiled: January 5, 2015Publication date: July 2, 2015Inventors: Bruce A. Molitoris, David M. Bedwell, Ruben M. Sandoval
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Patent number: 8951978Abstract: Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts to treat diseases that involve genetic mutations which introduce a missense or premature stop codon into a gene. Still other aspects include treating human or animal patients with the gentamicin congener C2 and derivatives and pharmaceutical salt thereof to overcome, or to at least mitigate, the symptoms of disease and disorders such as some forms of Becker's or Duchenne muscular dystrophy, Hurler's Syndrome and Cystic Fibrosis that have as their etiology the presence of a premature stop codon in a gene whose proper expression is necessary for good health.Type: GrantFiled: December 8, 2011Date of Patent: February 10, 2015Assignee: Indiana University Research and Technology Corp.Inventors: Bruce A. Molitoris, David M. Bedwell, Ruben M. Sandoval
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Publication number: 20140301952Abstract: The present invention relates generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system, wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system, wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV?TVPV.Type: ApplicationFiled: June 20, 2014Publication date: October 9, 2014Inventors: Bruce A. Molitoris, Exing Wang, Ruben M. Sandoval, JR.
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Publication number: 20140227189Abstract: A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.Type: ApplicationFiled: April 16, 2014Publication date: August 14, 2014Applicant: Indiana University Research and Technology CorporationInventors: Weiming YU, Bruce A. MOLITORIS, Ruben M. SANDOVAL
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Patent number: 8741263Abstract: A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.Type: GrantFiled: December 10, 2012Date of Patent: June 3, 2014Assignee: Indiana University Research and Technology CorporationInventors: Weiming Yu, Bruce A. Molitoris, Ruben M. Sandoval
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Publication number: 20130303254Abstract: A method for controlling a game comprising randomly selecting a first set of four items from a second set of fourteen items using a processor. Randomly selecting a third set of four items from a fourth set of thirteen items using a processor. Randomly selecting a fifth set of four items from a sixth set of thirteen items using a processor. Randomly selecting a seventh set of four items from an eighth set of fourteen items using a processor. Generating a game card displaying the first set of four items, the third set of four items, the fifth set of four items and the seventh set of four items on a user display.Type: ApplicationFiled: May 8, 2012Publication date: November 14, 2013Inventors: Ruben M. Sandoval, Leonardo R. Benitez
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Patent number: 8329143Abstract: A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.Type: GrantFiled: April 18, 2006Date of Patent: December 11, 2012Assignee: Indiana University Research and Technology CorporationInventors: Weiming Yu, Bruce A. Molitoris, Ruben M. Sandoval, Jr.
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Publication number: 20120276014Abstract: The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV?TVPV.Type: ApplicationFiled: April 29, 2010Publication date: November 1, 2012Applicant: PHARMACOPHOTONICS, INC.Inventors: Bruce A. Molitoris, Exing Wang, Ruben M. Sandoval
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Publication number: 20120157398Abstract: Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts to treat diseases that involve genetic mutations which introduce a missense or premature stop codon into a gene. Still other aspects include treating human or animal patients with the gentamicin congener C2 and derivatives and pharmaceutical salt thereof to overcome, or to at least mitigate, the symptoms of disease and disorders such as some forms of Becker's or Duchenne muscular dystrophy, Hurler's Syndrome and Cystic Fibrosis that have as their etiology the presence of a premature stop codon in a gene whose proper expression is necessary for good health.Type: ApplicationFiled: December 8, 2011Publication date: June 21, 2012Inventors: Bruce A. Molitoris, David M. Bedwell, Ruben M. Sandoval
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Publication number: 20100204171Abstract: Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts to treat diseases that involve genetic mutations which introduce a missense or premature stop codon into a gene. Still other aspects include treating human or animal patients with the gentamicin congener C2 and derivatives and pharmaceutical salt thereof to overcome, or to at least mitigate, the symptoms of disease and disorders such as some forms of Becker's or Duchenne muscular dystrophy, Hurler's Syndrome and Cystic Fibrosis that have as their etiology the presence of a premature stop codon in a gene whose proper expression is necessary for good health.Type: ApplicationFiled: May 28, 2009Publication date: August 12, 2010Inventors: Bruce A. Molitoris, David M. Bedwell, Ruben M. Sandoval
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Publication number: 20090234205Abstract: A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second molecule into an animal (e.g., a human patient), determining a molecular ratio of the molecules, and determining the physiological data based on the molecular ratio. The apparatus includes a number of finger receiving apertures, a light generation circuit, a light detection circuit, a pulse counting circuit, and a user interface.Type: ApplicationFiled: April 18, 2006Publication date: September 17, 2009Inventors: Weiming Yu, Bruce A. Molitoris, Ruben M. Sandoval, JR.