Abstract: A messaging system identifies a received message as a notification message from a conversation system in a media application. The messaging system obtains rendering information to render a current state of the conversation thread represented by the message. The message system renders the current state of the followed conversation thread, with actuators that provide interactive functionality allowing the user to interact with the conversation thread, in the message viewer of the user's messaging system.

Abstract: The present invention relates to a package seal control system (300), comprising a control unit (308), and data recording means (306) adapted to be communicatively connected to the control unit, wherein said data recording means (306) is adapted to monitor a longitudinal seal (302) extending in a direction conforming to a direction of flow of a packaging material (e.g. Tetra Pak) in a packaging and filling machine (100). The present invention further relates to its use and method for monitoring and optionally controlling the longitudinal seal (302) of a package material in a packaging and filling machine (100).

Abstract: A messaging system identifies a received message as a notification message from a conversation system in a media application. The messaging system obtains rendering information to render a current state of the conversation thread represented by the message. The message system renders the current state of the followed conversation thread, with actuators that provide interactive functionality allowing the user to interact with the conversation thread, in the message viewer of the user's messaging system.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract: A rotatable downhole cutting tool configured for enhanced drive consistency in low power circumstances. The tool is equipped with a hydraulic axial drive actuator suitable for use in wireline deployment. The actuator itself includes a reciprocating piston with a ball screw that threadably interfaces a ball nut for dampening the axial drive imparted by the piston. As such, even though hydraulically driven at generally well under about 10 horsepower, bounce in the axial drive is substantially eliminated.

Abstract: A shifting tool for use in shifting axial position of a shiftable element in a well. The tool comprises a linkage mechanism configured to translate an independent axial force into a dedicated radial force applied to expansive elements thereof. Thus, the elements may radially expand into engagement with the shiftable element free of any substantial axial force imparted thereon. As such, a more discretely controllable shifting actuation may be attained, for example, as directed from an oilfield surface. Indeed, real-time intelligent feedback may also be made available through use of such elements in conjunction with the noted linkage mechanism.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: The present disclosure provides processes for the preparation of a compound of formula I: which is useful as an antiviral agent. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Y, Z, n, R1 and R3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

Abstract: A modular donwhole tool system with a single electric hydraulic drive assembly. The assembly includes an electric hydraulic interface for coupling to any of a variety of different modular donwhole tools. Such tools may include a plug setting actuator, sleeve shifting actuator, valve effecting actuator and a variety of other radially or axially driven hydraulically powered actuators. Indeed, a variety of different actuators may be combined within the same system, tailored based on given downhole application needs. Thus, a viable off-the-shelf modular based on-site assemblage may be available to an operator for running off of a single electric hydraulic drive assembly.

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract: The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.