Patents by Inventor Ruben Van Summeren

Ruben Van Summeren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of isavuconazole or ravuconazole
    Patent number: 10590092
    Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: March 17, 2020
    Assignee: Basilea Pharmaceutica AG
    Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
  • PROCESS FOR THE MANUFACTURE OF ISAVUCONAZOLE OR RAVUCONAZOLE
    Publication number: 20190077771
    Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
    Type: Application
    Filed: September 11, 2017
    Publication date: March 14, 2019
    Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
  • Process for the manufacture of isavuconazole or ravuconazole
    Patent number: 9783508
    Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: October 10, 2017
    Assignee: Basilea Pharmaceutica AG
    Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
  • Manganese complex drier for coating compositions
    Patent number: 9228110
    Abstract: Use of a transition metal complex a) as a drier for air drying auto-oxidative resin composition comprising a polymer b) comprising unsaturated fatty acid residues, wherein the transition metal complex a) has a cation of the following structure (I) wherein R?C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms, or a polymeric residue; R1?H, C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms; X?O, OC(R2)O in which a=4 when X?O, and a=3 when X?OC(R2)O, R2?C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms, or a polymeric residue.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: January 5, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johan Franz Gradus Antonius Jansen, Engelina Catharina Kleuskens, Ruben Van Summeren, Paulus Lambertus Alsters
  • PROCESS FOR THE MANUFACTURE OF ISAVUCONAZOLE OR RAVUCONAZOLE
    Publication number: 20150239852
    Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
    Type: Application
    Filed: July 31, 2013
    Publication date: August 27, 2015
    Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
  • MANGANESE COMPLEX DRIER FOR COATING COMPOSITIONS
    Publication number: 20130203903
    Abstract: Use of a transition metal complex a) as a drier for air drying auto-oxidative resin composition comprising a polymer b) comprising unsaturated fatty acid residues, wherein the transition metal complex a) has a cation of the following structure (I) wherein R=C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms, or a polymeric residue; R1=H, C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms; X=O, OC(R2)O in which a=4 when X=O, and a=3 when X=OC(R2)O, R2=C1-C20 alkyl optionally substituted with heteroatoms, C6-C20 aryl optionally substituted with heteroatoms, or a polymeric residue.
    Type: Application
    Filed: February 11, 2011
    Publication date: August 8, 2013
    Inventors: Johan Franz Gradus Antonius Jansen, Engelina Catharina Kleuskens, Ruben Van Summeren, Paulus Lambertus Alsters