Abstract: A carpule syringe including a frame that receives a carpule the front end of which is closed by a thin elastomeric membrane which is pierced by a short rearwardly extending pointed end of a double ended hypodermic needle extending from the hub. The pointed front end of the needle is designed for injection into a patient. The hub of the needle has a rearwardly tapering socket for frictional engagement on a forwardly tapered tubular extension of a tubular plug that is secured into a threaded female bore at the delivery end of the carpule frame. To prevent accidental displacement of the needle hub, the same is detachably engaged by a pair of clamping arms that are pivotally mounted on a ring located at the front end of the syringe frame and are biased toward closed position.