Patents by Inventor Rudi D. Neirinckx

Rudi D. Neirinckx has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100160222
    Abstract: A topical formulation containing epidermal growth factor for treating psoriasis is described.
    Type: Application
    Filed: June 19, 2009
    Publication date: June 24, 2010
    Inventor: Rudi D. Neirinckx
  • Patent number: 7015199
    Abstract: Topical agent formulations for the treatment of psoriasis containing epidermal growth factor (EGF) as the active agent. EGF precursors or biological equivalents can be used. The formulation can also contain an anti-inflammatory. The formulation can contain sulfadiazine.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: March 21, 2006
    Inventor: Rudi D. Neirinckx
  • Patent number: 4990327
    Abstract: A dental desensitizing two-phase composition wherein one phase contains physiologically acceptable strontium ion and the second phase contains physiologically acceptable fluoride ion. The two phases are mixed when used.
    Type: Grant
    Filed: August 18, 1987
    Date of Patent: February 5, 1991
    Inventor: Rudi D. Neirinckx
  • Patent number: 4830848
    Abstract: A physiologically acceptable solution of tantalum-178 having an activity of 0.1 to 200 millicuries per milliliter of tantalum-178 solution is provided. The solution is obtained from tungsten-178 bound to a column of an anion exchange resin which forms tantalum-178 in situ by eluting the column with a hydrochloric acid solution containing hydrogen peroxide to form an acidic solution of tantalum-178. The acidic solution of tantalum-178 then is neutralized.
    Type: Grant
    Filed: March 19, 1987
    Date of Patent: May 16, 1989
    Assignee: Massachusetts Institute of Technology
    Inventors: Rudi D. Neirinckx, B. Leonard Holman, Michael A. Davis, Gale I. Harris
  • Patent number: 4789736
    Abstract: A family of propylene amine oxime ligands has the formula 2 ##STR1## wherein preferably R.sup.1 is Cl-C4 alkyl or phenyl and each of R, R.sup.2, R.sup.3 and R.sup.4 is H or Cl-C4 alkyl. The technetium-99m complexes of these ligands are lipophilic neutral complexes useful as diagnostic radiopharmaceuticals and particularly for brain scanning. The ligands show stereoisomerism. The preparation and properties of the dl- and meso-stereoisomers, and of the d- and l-enantiomers, are described. The l-enantiomer and the dl-stereoisomer of the preferred compound (2, R=R.sup.1 =R.sup.2 =CH.sub.3, R.sup.3 =R.sup.4 =H) show good retention in the brain.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: December 6, 1988
    Assignee: Amersham International plc
    Inventors: Lewis R. Canning, David P. Nowotnik, Rudi D. Neirinckx, Ian M. Piper
  • Patent number: 4419339
    Abstract: A method for the preparation of a technetium-99m complex having the formula[(L).sub.2.sup.99m Tc(X).sub.2 ].sup..sym.X.sup..crclbar.,which comprises adding technetium-99m to a complex having the formula[(L).sub.2 M(X).sub.2 ].sup..sym. X.sup..crclbar.and heating the mixture in the presence of a source of anion X.sup..crclbar., wherein each L is the same or different lipophilic ligand, each X is the same or different monovalent anionic ligand, and M is a non-toxic trivalent metal ion, is disclosed.
    Type: Grant
    Filed: August 5, 1981
    Date of Patent: December 6, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Rudi D. Neirinckx
  • Patent number: 4406877
    Abstract: The present invention provides a low .sup.82 Sr breakthrough eluent and method of generating .sup.82 Rb from .sup.82 Sr from a .sup.82 Sr charged inorganic adsorbant column. Eluting is done with a pharmaceutically acceptable saline and buffer solution, which is preferably isotonic .sup.82 Sr breakthroughs of 10.sup.-8 are obtained at clinically useful elution rates greater than 10 ml per minute. Phosphate and carbonate buffers are preferred. Al.sub.2 O.sub.3 and ZrO.sub.2 are preferred inorganic radiation damage resistant adsorbants.
    Type: Grant
    Filed: June 4, 1980
    Date of Patent: September 27, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudi D. Neirinckx, Michael D. Loberg
  • Patent number: 4400358
    Abstract: A composition comprising .sup.82 Sr and an adsorbant selected from the group consisting of tin oxide, hydrated tin oxide, polyantimonic acid, titanium oxide, and ferric oxide.A low .sup.82 Sr breakthrough method of generating .sup.82 Rb from a .sup.82 Sr charged adsorbant comprising eluting wherein said adsorbant is selected from the group consisting of tin oxide, polyantimonic acid, titanium oxide, ferric oxide, and hydrated tin oxide.
    Type: Grant
    Filed: November 21, 1980
    Date of Patent: August 23, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Rudi D. Neirinckx
  • Patent number: 4288424
    Abstract: A physiologically acceptable solution of gallium-68 fluorides, having an activity of 0.1 to 50 millicuries per milliliter of solution is provided. The solution is obtained from a generator comprising germanium-68 hexafluoride bound to a column of an anion exchange resin which forms gallium-68 in situ by eluting the column with an acid solution to form a solution containing .sup.68 Ga-fluorides. The solution then is neutralized prior to administration.
    Type: Grant
    Filed: January 15, 1979
    Date of Patent: September 8, 1981
    Assignee: Massachusetts Institute of Technology
    Inventors: Rudi D. Neirinckx, Michael A. Davis
  • Patent number: 4264468
    Abstract: A generator for obtaining radioactive gallium-68 from germanium-68 bound in a resin containing unsubstituted phenolic hydroxyl groups. The germanium-68 is loaded into the resin from an aqueous solution of the germanium-68. A physiologically acceptable solution of gallium-68 having an activity of 0.1 to 50 millicuries per milliliter of gallium-68 solution is obtained. The solution is obtained from the bound germanium-68 which forms gallium-68 in situ by eluting the column with a hydrochloric acid solution to form an acidic solution of gallium-68. The acidic solution of gallium-68 can be neutralized.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: April 28, 1981
    Assignee: Massachusetts Institute of Technology
    Inventors: Rudi D. Neirinckx, Michael A. Davis