Patents by Inventor Rudi Hrncic

Rudi Hrncic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for amyloid removal using anti-amyloid antibodies
    Patent number: 8105594
    Abstract: Methods and related immunoglobulin peptides and fragments thereof are disclosed that enhance the cell-mediated immune response of a patient to deposits of amyloid fibrils. These methods exploit the opsonizing effect of antibodies directed toward amyloid material or its component parts.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: January 31, 2012
    Inventors: Alan Solomon, Rudi Hrncic, Jonathan Stuart Wall
  • METHODS FOR AMYLOID REMOVAL USING ANTI-AMYLOID ANTIBODIES
    Publication number: 20100322932
    Abstract: Methods and related immunoglobulin peptides and fragments thereof are disclosed that enhance the cell-mediated immune response of a patient to deposits of amyloid fibrils. These methods exploit the opsonizing effect of antibodies directed toward amyloid material or its component parts.
    Type: Application
    Filed: January 25, 2010
    Publication date: December 23, 2010
    Inventors: Alan Solomon, Rudi Hrncic, Jonathan Stuart Wall
  • Diagnostic and Therapeutic Potential of Immune Globulin Intravenous (IGIV) Products
    Publication number: 20090232733
    Abstract: The present invention provides IGIV and IGIV enriched for binding to amyloid fibrils and to partially denatured amyloidogenic precursor polypeptides. The present invention also provides methods for obtaining IGIV enriched for binding to amyloid fibrils and to partially denatured amyloidogenic precursor polypeptides. The IGIV recognizes amyloid fibrils and partially denatured amyloidogenic precursor polypeptides. They are useful for treating diseases and conditions associated with amyloid deposition. The IGIV of the present invention also are useful for diagnosing and detecting amyloid deposition.
    Type: Application
    Filed: April 13, 2006
    Publication date: September 17, 2009
    Inventors: Brian O'Nuallain, Rudi Hrncic, Jonathan S. Wall, Alan Solomon
  • METHODS AND MATERIALS FOR PRODUCING A GENERIC ANTI-AMYLOID IMMUNE RESPONSE IN MAMMALS
    Publication number: 20090175894
    Abstract: Compositions containing fibrillar aggregates of amyloidogenic polypeptides and adjuvants are described as well as methods of using such compositions to induce generic anti-amyloid immune responses in mammals.
    Type: Application
    Filed: October 11, 2006
    Publication date: July 9, 2009
    Inventors: Todd E. Golde, Rudi Hrncic, Pritam Das
  • Methods of investigating, diagnosing, and treating amyloidosis
    Patent number: 7485616
    Abstract: The present invention provides a therapeutic method for removing amyloid fibrils from a patient. The present invention also provides a transgenic animal that develops systemic AA amyloidosis within three weeks for use as a tool to investigate AA amyloidosis and to evaluate agents that may be potentially useful in preventing and treating amyloid-related disorders. Further, the present invention provides diagnostic assays for monitoring immunoglobulin light chain fibrillogenesis in real-time and for identification of the chemical nature of the protein in amyloid deposits which enables the determination of the type of amyloidosis for therapeutic and prognostic purposes.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: February 3, 2009
    Assignee: University of Tennessee Research Foundation
    Inventors: Alan Solomon, Jonathan Stuart Wall, Rudi Hrncic, Maria Schell
  • METHODS FOR AMYLOID REMOVAL USING ANTI-AMYLOID ANTIBODIES
    Publication number: 20030147882
    Abstract: Methods and related immunoglobulin peptides and fragments thereof are disclosed that enhance the cell-mediated immune response of a patient to deposits of amyloid fibrils. These methods exploit the opsonizing effect of antibodies directed toward amyloid material or its component parts.
    Type: Application
    Filed: May 21, 1999
    Publication date: August 7, 2003
    Inventors: ALAN SOLOMON, RUDI HRNCIC, JONATHAN STUART WALL
  • Methods of investigating, diagnosing, and treating amyloidosis
    Publication number: 20020019335
    Abstract: The present invention provides a therapeutic method for removing amyloid fibrils from a patient. The present invention also provides a transgenic animal that develops systemic AA amyloidosis within three weeks for use as a tool to investigate AA amyloidosis and to evaluate agents that may be potentially useful in preventing and treating amyloid-related disorders. Further, the present invention provides diagnostic assays for monitoring immunoglobulin light chain fibrillogenesis in real-time and for identification of the chemical nature of the protein in amyloid deposits which enables the determination of the type of amyloidosis for therapeutic and prognostic purposes.
    Type: Application
    Filed: April 5, 2001
    Publication date: February 14, 2002
    Inventors: Alan Solomon, Jonathan Stuart Wall, Rudi Hrncic, Maria Schell