Abstract: Cytotoxic Michael addition derivatives of brefeldin A are described. Oxidation of thiol addition products of brefeldin A provides the corresponding sulfoxides and sulfones. The sulfoxides exhibited more cytotoxic activity than the corresponding sulfides and sulfones in a variety of human cancer cell lines. Pharmaceutical formulations of the disclosed cytotoxic derivatives are also described.

Abstract: Aroylaniline compounds which exhibit anti-retroviral activity, pharmaceutical compositions containing such aroylaniline compounds, and methods for treating a retroviral-infected host comprising administering an antiviral effective amount of an aroylaniline compound to a host.

Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.

Abstract: Novel compounds having anti-HIV activity are disclosed along with formulations and methods for treating human immunodeficiency viral infections employing these compounds.

Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.

Abstract: The invention involves the treatment of cancer in humans by administering water soluble derivatives of taxol. The types of cancer so treatable are those sensitive to treatment with taxol.

Abstract: This invention relates to new cis diamino platinum complexes; to compositions comprising these complexes; and to processes for their utility as fungicides, bacteriocides and as inhibitors of the growth of cancer in warm-blooded animals, wherein the complex is of the formula: [B(CH.sub.2).sub.n NH.sub.2 ].sub.2 Pt-M and ##STR1## wherein Pt is platinum II or platinum IV; M is selected from Y.sub.2, cyclic ##STR2## cyclic ##STR3## and cyclic ##STR4## when Pt is platinum II and X.sub.4 when Pt is platinum IV; each a is independently 1 or 2; n is from 0-3; each Y is independently --Cl, --Br, --I, --OH, --ONO.sub.2, --OSO.sub.

Abstract: Affixable paper that can be detached substantially non-destructively is disclosed. A non-essential portion of the affixable paper is so attached to a second paper with a moist adhesive in the form of microdots or microlines that after secure attachment, the affixable paper can be removed from the second paper in substantially original condition. The affixable paper may have cut scores to facilitate removal.

Abstract: Antineoplastic, water soluble, taxol derivatives and methods for preparing the same are described.

Abstract: Chemical compounds are provided including pyrazine diazohydroxides (I), as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. Compounds of the invention have pharmacological properties and are useful cytostatic agents and cell growth inhibiting agents.

Abstract: New substituted N-methyl derivatives of mitindomide and methods of preparing the same are disclosed. The novel compounds are water soluble and have anti-neoplastic activity.

Abstract: Chemical compounds are provided including pyrazine diazohydroxides (I), as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. Compounds of the invention have pharmacological properties and are useful cytostatic agents and cell growth inhibiting agents.

Abstract: This invention is directed to substituted 4-phenoxy and 4-phenylthio prolines of the formula ##STR1## which possess useful hypotensive activity.

Abstract: New substituted, formaldehyde derived mitindomide and methods of preparing the same are disclosed. The novel compounds are water soluble and have anti-neoplastic activity. The formaldehyde derived mitindomide is prepared by reacting mitindomide with formaldehyde and further acetylating the derived hydroxymethyl compound. The amido compounds can be derived by reacting mitindomide in mannich fashion, i.e-formaldehyde and secondary amines.

Abstract: New substantially isomerically pure tetrahalo (1,2-diaminocyclohexane) Pt (IV) complexes having antineoplastic activity are disclosed.

Abstract: Compounds of the formula ##STR1## are disclosed. They possess angiotensin converting enzyme inhibition activity and diuretic activity and are therefore useful as antihypertensive agents.

Abstract: Antiinflammatory activity is exhibited by steroids having the formula ##STR1## or the 1,2-dehydro derivative thereof, wherein R.sub.1 is alkyl, alkanoyloxyalkyl, arylcarbonyloxyalkyl, alkenyl, alkynyl, cycloalkyl, aryl or arylalkyl;R.sub.2 is hydrogen, hydroxy, alkoxy, aryloxy, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or halogen;R.sub.3 is hydrogen, methyl, hydroxy or halogen; andn is 0, 1 or 2.

Abstract: Compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, halogen, trifluoromethyl, aminosulfonyl, nitro, alkyl or alkoxy;R.sub.3 is hydrogen, alkyl, or phenylmethyl;R.sub.4 is hydrogen, alkyl, or phenyl, and R.sub.15 is alkyl, phenyl or phenylmethyl, or R.sub.4 and R.sub.15 together are --(CH.sub.2).sub.m -- wherein m is 1 or 2;R.sub.5,R.sub.6,R.sub.7,R.sub.8,R.sub.9,R.sub.10,R.sub.11,R.sub.12,R.sub.13 and R.sub.14 are each independently hydrogen, halogen, alkyl or phenyl;n.sub.1,n.sub.2,n.sub.3,n.sub.4 and n.sub.5 are each independently 0 or 1;with the proviso that if R.sub.4 and R.sub.15 together are --(CH.sub.2).sub.m -- the sum of n.sub.1, n.sub.2, n.sub.3, n.sub.4, n.sub.5 and m is 2 or 3;have diuretic activity.

Abstract: Compounds having the formula ##STR1## wherein: R.sub.1 is hydrogen, alkyl, aryl or arylalkyl;R.sub.2 is hydrogen and R.sub.3 is hydrogen, hydroxy, alkoxy or halogen, or together R.sub.2 and R.sub.3 can be .dbd.Q or --X--(CH.sub.2).sub.t --X-- wherein X is oxygen or sulfur and t is 2 or 3;R.sub.4 is hydrogen or alkyl;R.sub.5 is hydrogen, alkyl or trifluoromethyl;R.sub.6 is alkyl of 1 to 20 carbon atoms, aryl, arylalkyl or a 5- or 6-membered heterocyclic group having 1 to 2 nitrogen, sulfur or oxygen atoms in the ring;R.sub.7 is aryl;m is 0, 1 or 2; andn is 1 or 2have useful hypotensive activity.

Abstract: Benzimidazolederivatives are provided having the structure ##STR1## wherein R.sup.1 is lower alkyl, phenyl-lower alkyl, halo-lower alkyl, mono-lower alkylaminoalkyl, di-lower alkylaminoalkyl, and alkyl pyridinium halide, R.sup.2 and R.sup.3 may be the same or different and are hydrogen or lower alkyl, R.sup.4 is cycloalkyl or cycloalkenyl, and m is 0 to 3, n is 0 to 3, m+n being .ltoreq.5. These compounds are useful as anthelmintic agents.