Patents by Inventor Rudolf Hanko
Rudolf Hanko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120021441Abstract: The invention relates to a method for determining the isoform composition of erythropoietin, comprising the following steps: a) isoelectrical focusing of a sample comprising erythropoietin in a gel over a pH range having a lower limit of 2.5 to 3.5 and an upper limit of 5 to 8, wherein the sample comprising erythropoietin originates from a culture supernatant of erythropoietin producing eukaryotic cells; b) transferring of the proteins comprised and separated in the gel to a membrane; c) verifying the erythropoietin bound to the membrane by specific antibodies; and to a method for in-process control of culture supernatants of erythropoietin producing eukaryotic cells during the fermentative production process.Type: ApplicationFiled: December 7, 2009Publication date: January 26, 2012Applicant: Evonik Degussa GmbHInventors: Franz-Rudolf Kunz, Florian Glaser, Wolfgang Wienand, Rudolf Hanko, Wilfried Eul, Dietmar Reichert
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Publication number: 20110189732Abstract: The present invention relates to a process for the fermentative continuous production of erythropoietin, where eukaryotic erythropoietin-producing cells are cultured in a perfusion reactor while retaining the cells, the glucose concentration in the culture supernatant being adjusted via the perfusion rate and the cell number via the cell retention rate and/or the outward transferal of defined amounts of cell-containing culture medium from the bioreactor within preset zones.Type: ApplicationFiled: June 3, 2009Publication date: August 4, 2011Applicant: EVONIK DEGUSSA GMBHInventors: Wolfgang Wienand, Franz-Rudolf Kunz, Dietmar Reichert, Wilfried Eul, Rudolf Hanko, Christian Birr, Monika Singhofer-Wowra, Dagmar Schopohl-König, Lars Faber
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Publication number: 20110152506Abstract: The present invention relates to a method for preparing erythropoietin, wherein culture supernatant of erythropoietin-producing eukaryotic cells containing erythropoietin are subjected to the following steps: a) Removing the cell components; and b) treating the product from a) to the following chromatography steps in the sequence indicated i) reversed phase chromatography; ii) anion exchange chromatography; iii) hydroxyapatite chromatography.Type: ApplicationFiled: May 28, 2009Publication date: June 23, 2011Applicant: EVONIK DEGUSSA GMBHInventors: Wolfgang Wienand, Franz-Rudolf Kunz, Dietmar Reichert, Wilfried Eul, Rudolf Hanko, Christian Birr, Monika Singhofer-Wowra, Dagmar Schopohl-König, Lars Faber
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Patent number: 6130318Abstract: The present invention relates to novel hIL-4 mutant proteins, to processes for preparing them, and to their use as medicaments, in particular in overshooting, falsely regulated immune reactions and autoimmune diseases.Type: GrantFiled: December 19, 1996Date of Patent: October 10, 2000Assignee: Bayer AktiengellschaftInventors: Hanno Wild, Rudolf Hanko, Michael Dorschug, Hans-Dietrich Horlein, Jurgen Beunink, Heiner Apeler, Hermann Wehlmann, Walter Sebald
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Patent number: 5863930Abstract: Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.Type: GrantFiled: December 18, 1995Date of Patent: January 26, 1999Assignee: Bayer AktiengesellschaftInventors: Jurgen Dressel, Peter Fey, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch, Siegfried Zaiss
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Patent number: 5776964Abstract: The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.Type: GrantFiled: March 1, 1996Date of Patent: July 7, 1998Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Klaus Mohrs, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Michael Matzke, Ulrich Niewohner, Siegfried Raddatz, Thomas Kramer, Matthias Muller-Gliemann, Hans-Peter Bellemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil
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Patent number: 5712296Abstract: Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.Type: GrantFiled: October 27, 1995Date of Patent: January 27, 1998Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
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Patent number: 5691359Abstract: Heterocyclylcarbonyl substituted benzofuranyl- and thiophenyl-alkanecarboxylic acid derivatives are prepared by reacting appropriately substituted hydroxybenzene butanoic acid esters with heterocyclic ketones. The inventive compounds can be used for the preparation of medicaments, particularly of medicaments for the treatment and prevention of acute and chronic inflammatory processes.Type: GrantFiled: May 23, 1995Date of Patent: November 25, 1997Assignee: Bayer AktiengesellschaftInventors: Rudiger Fischer, Gabriele Braunlich, Mazen Es-Sayed, Rudolf Hanko, Stephen Tudhope, Graham Sturton, Trevor Abram, Mary F. Fitzgerald
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Patent number: 5627285Abstract: Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating.The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in particular for the treatment of high blood pressure and atherosclerosis.Type: GrantFiled: September 6, 1995Date of Patent: May 6, 1997Assignee: Bayer AktiengesellschaftInventors: Rudolf Hanko, J urgen Dressel, Peter Fey, Walter H ubsch, Thomas Kr amer, Ulrich E. M uller, Matthias M uller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu
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Patent number: 5622989Abstract: 6-Amino-benzofuryl- and thienyl-derivatives can be prepared by reacting appropriate amino-substituted benzoyl phenols with appropriate substituted acetophenones and subsequent modification of the substituents. The compounds are useful for the treatment of actual and chronic inflammatory diseases, particularly of the airways and the gastro-intestinal tract.Type: GrantFiled: May 23, 1995Date of Patent: April 22, 1997Assignee: Bayer AktiengesellschaftInventors: Gabriele Br aunlich, R udiger Fischer, Mazen Es-Sayed, Rudolf Hanko, Stephen Tudhope, Graham Sturton, Trevor Abram, Wendy J. McDonald-Gibson, Mary F. Fitzgerald
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Patent number: 5599823Abstract: Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.Type: GrantFiled: June 29, 1994Date of Patent: February 4, 1997Assignee: Bayer AktiengesellschaftInventors: Matthias M uller-Gliemann, Martin Beuck, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Stefan Wohlfeil, Walter H ubsch, J urgen Dressel, Peter Fey, Rudolf Hanko, Thomas Kr amer, Ulrich M uller, Siegfried Zaiss
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Patent number: 5596006Abstract: Antihypertensive and antiatherosclerotic trisubstituted biphenyls of the formula ##STR1## in which R.sub.1 represents a carboxyl radical or represents a C.sub.1 -C.sub.8 -alkoxycarbonyl radical,R.sub.2 represents straight-chain or branched C.sub.1 -C.sub.8 -alkyl,R.sub.3 represents halogen, hydroxyl, cyano, C.sub.1 -C.sub.6 -alkoxy, straight-chain or branched C.sub.1 -C.sub.8 -alkyl, trifluoromethyl, trifluoromethoxy, carboxamido, carboxyl, C.sub.1 -C.sub.8 -alkoxycarbonyl or nitroandR.sub.4 represents a carboxyl radical or represents tetrazolyl,and salts thereof.Type: GrantFiled: January 3, 1995Date of Patent: January 21, 1997Assignee: Bayer AktiengesellschaftInventors: J urgen Dressel, Peter Fey, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich E. M uller, Matthias M uller-Gliemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch, Siegfried Zaiss
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Patent number: 5594010Abstract: The substituted monopyridyl and bipyridyl derivatives are prepared by reacting substituted pyridine halides with phenylboronic acids. They are suitable for use as active compounds in medicaments for treating arterial hypertension and atherosclerosis.Type: GrantFiled: June 17, 1994Date of Patent: January 14, 1997Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Thomas Kr amer, J urgen Dressel, Rudolf Hanko, Walter H ubsch, Ulrich M uller, Matthias M uller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
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Patent number: 5576342Abstract: Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in medicaments.Type: GrantFiled: March 18, 1994Date of Patent: November 19, 1996Assignee: Bayer AktiengesellschaftInventors: Ulrich M uller, J urgen Dressel, Peter Fey, Rudolf Hanko, Walter H ubsch, Thomas Kr amer, Matthias M uller-Gliemann, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil, Andreas Knorr, Johannes-Peter Stasch, Siegfried Zaiss
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Patent number: 5565488Abstract: The inventive Oxalylamino-benzofuran- and benzothienyl-derivatives are prepared by reacting the appropriate amino substituted benzofuranes and benzothiophenes with oxalic acid derivatives. The inventive compounds are suitable for the prevention and treatment of acute and chronic inflammatory processes, particularly of the airways.Type: GrantFiled: May 23, 1995Date of Patent: October 15, 1996Assignee: Bayer AktiengesellschaftInventors: Gabriele Braunlich, Rudiger Fischer, Mazen Es-Sayed, Rudolf Hanko, Stephen Tudhope, Graham Sturton, Trevor Abram, Wendy J. McDonald-Gibson, Mary F. Fitzgerald
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Patent number: 5530016Abstract: Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.Type: GrantFiled: May 18, 1994Date of Patent: June 25, 1996Assignee: Bayer AktiengesellschaftInventors: Thomas Kramer, Rudolf Hanko, Jurgen Dressel, Peter Fey, Walter Hubsch, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
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Patent number: 5521206Abstract: The invention relates to phenylacetic acid derivatives of the formula ##STR1## which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.Type: GrantFiled: April 15, 1994Date of Patent: May 28, 1996Assignee: Bayer AktiengesellschaftInventors: Ulrich Muller, Klaus Mohrs, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Michael Matzke, Ulrich Niewohner, Siegfried Raddatz, Thomas Kramer, Matthias Muller-Gliemann, Hans-Peter Belleman, Martin Beuck, Stanislav Kazda, Stefan Wohlfeil
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Patent number: 5504213Abstract: The Benzofuranyl- and -thiophenyl-alkane-carboxylic acid derivatives are prepared Tby cyclisation of hydroxy acetophenones and related compounds or by Wittig-reaction of benzofuranyl aldehydes. The compounds can be used to prepared medicaments.Type: GrantFiled: April 29, 1994Date of Patent: April 2, 1996Assignee: Bayer AktiengesellschaftInventors: Rudiger Fischer, Gabriele Braunlich, Klaus-Helmut Mohrs, Rudolf Hanko, John-Edward Butler-Ransohoff, Mazen Es-Sayed, Graham Sturton, Steve Tudhope, Trevor Abram, Wendy J. McDonald-Gibson
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Patent number: 5492923Abstract: Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.Type: GrantFiled: April 29, 1994Date of Patent: February 20, 1996Assignee: Bayer AktiengesellschaftInventors: Peter Fey, Jurgen Dressel, Rudolf Hanko, Walter Hubsch, Thomas Kramer, Ulrich Muller, Matthias Muller-Gliemann, Martin Beuck, Hilmar Bischoff, Stefan Wohlfeil, Dirk Denzer, Stanislav Kazda, Johannes-Peter Stasch, Andreas Knorr, Siegfried Zaiss
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Patent number: 5475016Abstract: Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating.The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in particular for the treatment of high blood pressure and atherosclerosis.Type: GrantFiled: February 18, 1993Date of Patent: December 12, 1995Assignee: Bayer AktiengesellschaftInventors: Rudolf Hanko, Jurgen Dressel, Peter Fey, Walter Hubsch, Thomas Kramer, Ulrich E. Muller, Matthias Muller-Gliemann, Martin Beuck, Stanislav Kazda, Claudia Hirth-Dietrich, Andreas Knorr, Johannes-Peter Stasch, Stefan Wohlfeil, Ozkan Yalkinoglu