Patents by Inventor Rudolf Pfister
Rudolf Pfister has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4691040Abstract: 1-[2-(4,5,10,11-Tetrahydro-1H-dibenzo[a,d]cyclohepten-5-yl)ethyl]pyrrolidin e of the formula ##STR1## and its pharmaceutically acceptable acid addition salts, prepared through various intermediates, are described. The compounds have valuable histamine-H.sub.1 antagonistic properties and are suitable for the control or prevention of allergic reactions,such as, urticaria, hay fever, anaphylaxis and over-sensitivity to medicaments.Type: GrantFiled: February 5, 1985Date of Patent: September 1, 1987Assignee: Hoffmann-La Roche Inc.Inventors: Werner Aschwanden, Quirico Branca, Emilio Kyburz, Rudolf Pfister
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Patent number: 4544655Abstract: 4-Hydroxy-2-methyl-3-(2-pyridylcarbamoyl)-6-trifluoromethyl-2H-thieno[2,3-e ]-1,2-thiazine 1,1-dioxide of the formula ##STR1## and its pharmaceutically acceptable salts which possess valuable pharmacodynamic properties are described. More particularly, the compound and its salts display antiinflammatory, analgesic and antirheumatic activities and they are readily accessible by reacting a corresponding alkyl ester with 2-aminopyridine and, if desired, subsequent salt formation.Type: GrantFiled: August 31, 1983Date of Patent: October 1, 1985Assignee: Hoffmann-La Roche Inc.Inventors: Rudolf Pfister, Paul Zeller, Dieter Binder, Otto Hromatka
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Patent number: 4513002Abstract: 1-[2-(4,5,10,11-Tetrahydro-1H-dibenzo[a,d]cyclohepten-5-yl)ethyl]pyrrolidin e of the formula ##STR1## and its pharmaceutically acceptable acid addition salts, prepared through various intermediates, are described. The compounds have valuable histamine-H.sub.1 antagonistic properties and are suitable for the control or prevention of allergic reactions, such as, urticaria, hay fever, anaphylaxis and over-sensitivity to medicaments.Type: GrantFiled: December 14, 1981Date of Patent: April 23, 1985Assignee: Hoffmann-La Roche Inc.Inventors: Werner Aschwanden, Quirico Branca, Emilio Kyburz, Rudolf Pfister
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Patent number: 4448991Abstract: Cyclohexenes of the formula ##STR1## wherein R.sup.1 is hydroxy or lower alkoxy; n is 1 or 2; R.sup.2 is lower alkyl; and R.sup.3 is hydrogen, lower alkyl, lower alkenyl or lower cycloalkylmethyl,and their pharmaceutically acceptable acid addition salts are disclosed. The compounds of formula I have analgesic activity and are useful for the control of pains.Type: GrantFiled: March 24, 1982Date of Patent: May 15, 1984Assignee: Hoffmann-La Roche Inc.Inventors: Hans Bruderer, Albert E. Fischli, Rudolf Pfister
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Patent number: 4348519Abstract: The invention relates to thiazine derivatives of the formula ##STR1## wherein R.sup.1 is lower alkyl and R.sup.2 is the residue of an aromatic heterocycle containing 1 to 4 hetero atoms optionally substituted by one or two lower alkyl groups, or a phenyl or benzyl group optionally substituted by halogen, hydroxy, lower alkyl, trifluoromethyl, nitro or lower alkoxy, and pharmaceutically acceptable salts thereof. The compounds of formula I are useful for the control or prevention of inflammation, pains, rheumatics and thromboses.Type: GrantFiled: May 16, 1980Date of Patent: September 7, 1982Assignee: Hoffmann-La Roche Inc.Inventor: Rudolf Pfister
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Patent number: 4336268Abstract: Cyclohexenes of the formula ##STR1## wherein R.sup.1 is hydroxy or lower alkoxy; n is 1 or 2; R.sup.2 is lower alkyl; and R.sup.3 is hydrogen, lower alkyl, lower alkenyl or lower cycloalkylmethyl, and their pharmaceutically acceptable acid addition salts are disclosed. The compounds of formula I have analgesic activity and are useful for the control of pains.Type: GrantFiled: January 27, 1981Date of Patent: June 22, 1982Assignee: Hoffmann-La Roche Inc.Inventors: Hans Bruderer, Albert E. Fischli, Rudolf Pfister
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Patent number: 4269788Abstract: Cyclohexadiene derivatives of the formula ##STR1## wherein R.sup.1,R.sup.2,R.sup.3 and R.sup.4 are as hereinafter set forth, are described. The compounds of formula I are useful as analgesic agents.Type: GrantFiled: October 4, 1979Date of Patent: May 26, 1981Assignee: Hoffmann-La Roche Inc.Inventors: Peter M. Muller, Rudolf Pfister, Rene Urban
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Patent number: 4224445Abstract: The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## and the broken line represents the double bond in group (a); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and anti-rheumatic activity.Type: GrantFiled: October 30, 1978Date of Patent: September 23, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Otto Hromatka, Dieter Binder, Rudolf Pfister, Paul Zeller
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Patent number: 4187303Abstract: Thienothiazine derivatives of the formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as hereinafter set forth, and their tautomers are described. The thienothiazine derivatives are useful as anti-inflammatory, analgesic, antirheumatic and antithrombotic agents.Type: GrantFiled: August 15, 1978Date of Patent: February 5, 1980Assignee: Hoffmann-La Roche Inc.Inventors: Otto Hromatka, Dieter Binder, Paul Zeller, Rudolf Pfister
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Patent number: 4180662Abstract: Anti-inflammatory, analgesic, anti-rheumatic and anti-thrombotic thienothiazine derivatives having the formula ##STR1## wherein A together with the two carbon atoms forms the group ##STR2## and the dotted line indicates the double bond present in the first and last thieno structures above, R.sup.1 is lower alkyl, R.sup.2 is the radical of an aromatic heterocycle with 1 to 4 hetero atoms optionally substituted by one or two lower alkyl groups, or a phenyl radical optionally substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy, R.sup.3 is halogen and R.sup.3' is hydrogen or halogen,and pharmaceutically acceptable salts thereof are described.Type: GrantFiled: August 31, 1978Date of Patent: December 25, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Rudolf Pfister, Paul Zeller, Dieter Binder, Otto Hromatka
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Patent number: 4177193Abstract: The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## and the broken line represents the double bond in group (a); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and anti-rheumatic activity.Type: GrantFiled: October 30, 1978Date of Patent: December 4, 1979Assignee: Hoffman-La Roche Inc.Inventors: Otto Hromatka, Dieter Binder, Rudolf Pfister, Paul Zeller
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Patent number: 4175085Abstract: Thienothiazine derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl; R.sub.2 is an unsubstituted aromatic heterocyclic radical which contains from 1 to 4 hetero atoms or one which is substituted by one or two lower alkyl groups, or is an unsubstituted phenyl radical or one substituted by halogen, hydroxy, lower alkyl, nitro, trifluoromethyl or lower alkoxy; and R.sub.3 and R.sub.4, independently, are hydrogen or lower alkyl,prepared inter alia, from novel intermediates, are described. The end products are useful as anti-inflammatory, analgesic and anti-rheumatic agents.Type: GrantFiled: March 2, 1978Date of Patent: November 20, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Dieter Binder, Otto Hromatka, Rudolf Pfister, Paul Zeller
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Patent number: 4173577Abstract: Phenylacetohydroxamic acids having the formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, independently of each other, represent hydrogen, chlorine, fluorine or bromine atoms or an alkyl or alkoxy group having at most 6 carbon atoms, and wherein R.sub.2 may additionally represent a trifluoromethyl group with the proviso that R.sub.1, R.sub.2 and R.sub.3 may not simultaneously represent hydrogen atoms and their pharmaceutically acceptable salts with bases, which compounds inhibit plateletaggregation and exhibit valuable pharmacological, in particular, antiphlogistic, analgesic and antipyretic activity.Type: GrantFiled: February 13, 1978Date of Patent: November 6, 1979Assignee: Ciba-Geigy CorporationInventors: Alfred Sallmann, Rudolf Pfister
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Patent number: 4134898Abstract: The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## AND THE BROKEN LINE REPRESENTS THE DOUBLE BOND IN GROUP (A); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Type: GrantFiled: November 17, 1977Date of Patent: January 16, 1979Assignee: Hoffmann-La Roche Inc.Inventors: Otto Hromatka, Dieter Binder, Rudolf Pfister, Paul Zeller
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Patent number: 4092430Abstract: Phenylacetohydroxamic acids having the formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4, independently of each other, represent hydrogen, chlorine, fluorine or bromine atoms or an alkyl or alkoxy group having at most 6 carbon atoms, and wherein R.sub.2 may additionally represent a trifluoromethyl group with the proviso that R.sub.1, R.sub.2 and R.sub.3 may not simultaneously represent hydrogen atoms and their pharmaceutically acceptable salts with bases, which compounds inhibit plateletaggregation and exhibit valuable pharmacological, in particular, antiphlogistic, analgesic and antipyretic activity.Type: GrantFiled: March 11, 1976Date of Patent: May 30, 1978Assignee: Ciba-Geigy CorporationInventors: Alfred Sallmann, Rudolf Pfister
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Patent number: 4090020Abstract: Thienothiazine derivatives of the formula ##STR1## wherein R.sub.1 is lower alkyl; R.sub.2 is an unsubstituted aromatic heterocyclic radical which contains from 1 to 4 hetero atoms or one which is substituted by one or two lower alkyl groups, or is an unsubstituted phenyl radical or one substituted by halogen, hydroxy, lower alkyl, nitro, trifluoromethyl or lower alkoxy; and R.sub.3 and R.sub.4, independently, are hydrogen or lower alkyl,Prepared inter alia, from novel intermediates, are described. The end products are useful as anti-inflammatory, analgesic and anti-rheumatic agents.Type: GrantFiled: February 9, 1977Date of Patent: May 16, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Dieter Binder, Otto Hromatka, Rudolf Pfister, Paul Zeller
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Patent number: 4076709Abstract: The present invention relates to compounds of the formula ##STR1## wherein A together with the two carbon atoms to which it is attached forms the group ##STR2## AND THE BROKEN LINE REPRESENTS THE DOUBLE BOND IN GROUP (A); R.sub.1 represents a lower alkyl group; R.sub.2 represents the residue of an aromatic heterocyclic ring containing from 1 to 4 hetero atoms, which may be substituted by one or two lower alkyl groups, or a phenyl group which may be substituted by halogen, hydroxy, lower alkyl, trifluoromethyl or lower alkoxy and R.sub.3 and R.sub.4 each represent a hydrogen atom or a lower alkyl group.Also provided are methods for their preparation. The thienothiazine derivatives provided by this invention have anti-flammatory, analgesic and antirheumatic activity.Type: GrantFiled: August 21, 1975Date of Patent: February 28, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Otto Hromatka, Dieter Binder, Rudolf Pfister, Paul Zeller