Abstract: The invention relates to a process for analysing single molecules, in particular for sequencing of single nucleic acid molecules.

Abstract: The invention relates to a process and a device for analyzing single molecules, particularly to the parallel analysis of a plurality of single molecules. It is suitable for detecting interactions, e.g. binding between single molecules and/or reactions, e.g. elongation or degradation of single molecules. Particularly, the process of the invention relates to the sequencing of single nucleic acid molecules. The single molecule to be analyzed is present in free form, i.e. dissolved or suspended in a liquid medium, within a reaction space formed around the sample spot. According to the present invention, an electrical field is applied across the reaction space, whereby a concentration of single molecules, at the sample spots is effected.

Abstract: The invention relates to a process for analysing single molecules, in particular for sequencing of single nucleic acid molecules.

Abstract: An apparatus for characterizing luminescent entities by excitation comprising: • a substrate (6) being in contact with a solution comprising luminescent entities; • a source of electromagnetic radiation (4) providing at least a primary beam of radiation (8); an objective (5); a first optical element (1) capable of transforming the intensity profile of the primary beam (8) into an arbitrary secondary intensity profile (distribution) (9); a second optical element (2) capable of separating (discriminating) radiation by wavelength; and a detector (7), where the arbitrary secondary intensity profile has at least an off-center circular continuous intensity distribution (33) focused on the back focal plane (12) of the objective forming a collimated beam (10) capable of creating an evanescent field on the side of the substrate where the solution comprising luminescent entities are located, where the evanescent field excites the luminescent entities thereby creating emission radiation separated by the second optical e

Abstract: The invention relates to a process and a device for analysing single molecules, particularly to the parallel analysis of a plurality of single molecules. It is suitable for detecting interactions, e.g. binding between single molecules and/or reactions, e.g. elongation or degradation of single molecules. Particularly, the process of the invention relates to the sequencing of single nucleic acid molecules. The single molecule to be analysed is present in free form, i.e. dissolved or suspended in a liquid medium, within a reaction space formed around the sample spot. According to the present invention, an electrical field is applied across the reaction space, whereby a concentration of single molecules, at the sample spots is effected.

Abstract: The invention relates generally to methods for the diagnosis and/or prognosis of an amyloid-associated disease, methods of treating an amyloid-associated disease, and methods of identifying an agent for the treatment of an amyloid-associated disease, as well as related uses and kits of parts

Abstract: The invention relates to a process for analysing single molecules, in particular for sequencing of single nucleic acid molecules.

Abstract: The invention relates to a process for analysing single molecules, in particular for sequencing of single nucleic acid molecules.

Abstract: The invention relates to a process for parallel high throughput sequencing of nucleic acid molecules, in particular in the single molecule format.

Abstract: An apparatus for characterizing luminescent entities by excitation comprising: •a substrate (6) being in contact with a solution comprising luminescent entities; •a source of electromagnetic radiation (4) providing at least a primary beam of radiation (8); an objective (5); a first optical element (1) capable of transforming the intensity profile of the primary beam (8) into an arbitrary secondary intensity profile (distribution) (9); a second optical element (2) capable of separating (discriminating) radiation by wavelength; and a detector (7), where the arbitrary secondary intensity profile has at least an off-center circular continuous intensity distribution (33) focused on the back focal plane (12) of the objective forming a collimated beam (10) capable of creating an evanescent field on the side of the substrate where the solution comprising luminescent entities are located, where the evanescent field excites the luminescent entities thereby creating emission radiation separated by the second optical ele

Abstract: The invention relates to a process for parallel high throughput sequencing of nucleic acid molecules, in particular in the single molecule format.

Abstract: The invention relates to a process and a device for analysing single molecules, particularly to the parallel analysis of a plurality of single molecules. It is suitable for detecting interactions, e.g. binding between single molecules and/or reactions, e.g. elongation or degradation of single molecules. Particularly, the process of the invention relates to the sequencing of single nucleic acid molecules. The single molecule to be analysed is present in free form, i.e. dissolved or suspended in a liquid medium, within a reaction space formed around the sample spot. According to the present invention, an electrical field is applied across the reaction space, whereby a concentration of single molecules, at the sample spots is effected.

Abstract: The invention relates to a process for parallel high throughput sequencing of nucleic acid molecules, in particular in the single molecule format.

Abstract: The invention relates to a process for analysing single molecules, in particular for sequencing of single nucleic acid molecules.

Abstract: The invention relates to a process for parallel high throughput sequencing of nucleic acid molecules, in particular in the single molecule format.

Abstract: The invention relates to a method for selecting charged particles possessing a predetermined property from a population of a multiplicity of different particles, and also to a device which is suitable for implementing the method.

Abstract: The present invention pertains to a method for evaluation of the toxicity of compounds comprising the use of spermatozoa. The inventions also relates to a high throughput system for the toxicity evaluation.

Abstract: The invention relates to a method and a device for evanescence-based multiplex sequencing of nucleic acid molecules immobilized on a support.

Abstract: The invention relates to a Method for determining the flow of a fluid close to a surface of an object immersed in the fluid by analyzing at least one confocal measurement volume in the fluid, comprising the steps of: focusing light into the at least one confocal volume within the fluid; detecting and determining of at least one optical parameter of at least one particle comprised in the confocal volume; and determining the flow velocity of the fluid based on the determination of the at least one optical parameter using a correlation function, in particular an auto correlation function or a cross correlation function. Furthermore, the invention relates to an object immersed in a fluid and comprising a measuring device for carrying out the method.

Abstract: The present invention refers to a mobile device for measuring dynamic parameters of particles, e.g. spermatozoa, such as the translation speed and the rotational speed of particles.